SPLITOMICIN

ChemicalBook > CAS DataBase List > SPLITOMICIN

Product Name: SPLITOMICIN
CAS No.: 5690-03-9
Chemical Name: SPLITOMICIN
Synonyms: Spitomicin;Splitomycin;SPLITOMICIN;Splitomicin >1H-Benzo[f]chromen-3(2H)-one;1,2-Dihydro-3H-benzo[f]chromen-3-one;1,2-DIHYDRO-3H-NAPHTHO[2,1-B]PYRAN-3-ONE;2-Hydroxy-1-naphthalenepropanoic acid delta-lactone;Inhibitor,Histone deacetylases,Splitomycin,HDAC,inhibit,Splitomicin
CBNumber: CB5227437
Molecular Formula: C13H10O2
Formula Weight: 198.22
MOL File: 5690-03-9.mol

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SPLITOMICIN Property

Melting point:: 73-74.5℃
storage temp.: 2-8°C
solubility: insoluble in H2O; ≥44.2 mg/mL in EtOH with ultrasonic; ≥9.05 mg/mL in DMSO
form: solid
color: White to Almost white

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Safety

WGK Germany: 3
HS Code: 2932.20.4500

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S4068
Product name: Splitomicin
Purity: ≥98% (HPLC), powder
Packaging: 5mg
Price: $55.62
Updated: 2024/03/01

Sigma-Aldrich

Product number: 567750
Product name: Splitomicin - CAS 5690-03-9 - Calbiochem
Purity: A cell-permeable lactone derived from β-naphthol that acts as a selective inhibitor of NAD+-dependent histone deacetylase activity of Sir2 protein (IC?? = 60 μM).
Packaging: 5MG
Price: $201
Updated: 2024/03/01

TCI Chemical

Product number: S0892
Product name: Splitomicin
Purity: >98.0%(GC)
Packaging: 1g
Price: $424
Updated: 2024/03/01

TCI Chemical

Product number: S0892
Product name: Splitomicin
Purity: >98.0%(GC)
Packaging: 200mg
Price: $142
Updated: 2024/03/01

Cayman Chemical

Product number: 13168
Product name: Splitomicin
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

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SPLITOMICIN Chemical Properties,Usage,Production

Uses

Splitomicin is a selective and potent inhibitor of Sir2 (silent information regulator 2), producing an inhibitory effect on neutrophils. Acts as an anti-inflammatory agent.

Definition

ChEBI: A benzochromenone that is 2,3-dihydro-1H-benzo[f]chromene substituted by an oxo group at position 3. It has been found to exhibit potential inhibitory activity against Sir2 proteins.

Synthesis Reference(s)

Journal of the American Chemical Society, 69, p. 2341, 1947 DOI: 10.1021/ja01202a027

General Description

A cell-permeable and selective inhibitor of NAD⁺-dependent deacetylase activity of Sir2 protein (IC₅₀ = 60 μM). Creates a phenocopy of the sir2 deletion mutant in S. cerevisiae and sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Reported to act by either altering or blocking access to the acetylated histone-binding pocket.

Biological Activity

Inhibitor of Sir2p (IC 50 = 60 μ M), an NAD + -dependent Sir2 family deacetylase required for chromatin-dependent silencing in yeast.

Biochem/physiol Actions

Cell permeable: yes

storage

+4°C

SPLITOMICIN Preparation Products And Raw materials

Raw materials

Preparation Products

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SPLITOMICIN Suppliers

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5690-03-9, SPLITOMICINRelated Search:

1H-Benz[de]isoquinoline-2(3H)-butanamide SCRIPTAID Sodium 4-phenylbutyrate BENZOTRIAZOL-1-YL-(2,4-DICHLORO-PHENYL)-METHANONE APICIDIN CAY10603 OXAMFLATIN Entinostat HC TOXIN Parthenolide Hematoxylin Tacedinaline JNJ-26481585 Mocetinostat (MGCD0103) Tubacin CRA-02478 M344 SPLITOMICIN

SPLITOMICIN

1H-Benzo[f]chromen-3(2H)-one

1,2-DIHYDRO-3H-NAPHTHO[2,1-B]PYRAN-3-ONE

2-Hydroxy-1-naphthalenepropanoic acid delta-lactone

Splitomycin

Splitomicin &gt

Spitomicin

1,2-Dihydro-3H-benzo[f]chromen-3-one

Inhibitor,Histone deacetylases,Splitomycin,HDAC,inhibit,Splitomicin

5690-03-9

BioChemical

Cell Biology

Cell Signaling and Neuroscience

Gene Regulation and Expression

DNA-RNA Transcription Regulators

Inhibitors