APICIDIN

Product Name
APICIDIN
CAS No.
183506-66-3
Chemical Name
APICIDIN
Synonyms
OSI 2040;APICIDIN;Ccris 9163;Apicidin Ia;Apicidin (OSI 2040);APICIDIN, FUSARIUM SPECIES;CYCLO-[L-(2-AMINO-8-OXODECANOYL)-L-(N-METHOXYTRYPTOPHAN)-L-ISOLEUCYL-D-PIPECOLINYL;CYCLO-L-(2-AMINO-8-OXODEACANOYL)-L-(N-METHOXY-TRYPTOPHAN)-L-ISOLEUCYL-D-PIPECOLINYL;Cyclo(8-oxo-L-2-aMinodecanoyl-1-Methoxy-L-tryptophyl-L-isoleucyl- D-2-piperidinecarbonyl);Cyclo[(2S)-2-aMino-8-oxodecanoyl-1-Methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl]
CBNumber
CB4482789
Molecular Formula
C34H49N5O6
Formula Weight
623.78
MOL File
183506-66-3.mol
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APICIDIN Property

Density 
1.27±0.1 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
DMSO: ~1mg/mL
form 
solid
pka
13.09±0.70(Predicted)
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Safety

Hazard Codes 
T+
Risk Statements 
26/27/28
Safety Statements 
22-26-36/37/39-45
RIDADR 
UN 2811 6.1/PG 2
WGK Germany 
3
HS Code 
29419090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

H310Fatal in contact with skin

H330Fatal if inhaled

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P310Immediately call a POISON CENTER or doctor/physician.

P302+P350IF ON SKIN: Gently wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A8851
Product name
Apicidin
Purity
≥98% (HPLC), from microbial
Packaging
1mg
Price
$113
Updated
2021/03/22
Sigma-Aldrich
Product number
A8851
Product name
Apicidin
Purity
≥98% (HPLC), from microbial
Packaging
5mg
Price
$390
Updated
2021/03/22
Cayman Chemical
Product number
10575
Product name
Apicidin
Purity
≥90%
Packaging
1mg
Price
$47
Updated
2021/03/22
Cayman Chemical
Product number
10575
Product name
Apicidin
Purity
≥90%
Packaging
5mg
Price
$188
Updated
2021/03/22
Cayman Chemical
Product number
10575
Product name
Apicidin
Purity
≥90%
Packaging
10mg
Price
$353
Updated
2021/03/22
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APICIDIN Chemical Properties,Usage,Production

Chemical Properties

Solid

Uses

Apicidin is a potent (nM) cell permeable inhibitor of histone deacetylase. Also, Apicidin exhibits antiprotozoal and potential antimalarial properties. Apicidin has antiproliferative activity on HeLa cells accompanied by cell arrest at the G1 phase. Apicidin induces selective changes in the expression of p21 and gelsolin.

Uses

Apicidin is a cyclic peptide antibiotic with broad spectrum antiparasitic and antiprotozoan activity. Apicidin, a histone deacetylase inhibitor, is anti-angiogenic and induces apoptosis.

Enzyme inhibitor

This fungal metabolite and potential oral chemotherapeutic agent (FW = 623.79 g/mol; CAS 183506-66-3), also known as [cyclo(N-O-methyl-L- tryptophanyl-L-isoleucinyl-D-pipecolinyl-L-2-amino-8-oxodecanoyl)], is an antiprotozoal agent. It is cell permeable and is a strong inhibitor of histone deacetylase (IC50 = 0.7 nM). Apicidin also inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin. Apicidin’s low bioavailability of apicidin is mainly due to the P-gycoprotein-mediated efflux.

APICIDIN Preparation Products And Raw materials

Raw materials

Preparation Products

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APICIDIN Suppliers

J & K SCIENTIFIC LTD.
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010-82848833- ;010-82848833-
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86-10-82849933
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jkinfo@jkchemical.com;market6@jkchemical.com
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China
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Alabiochem Tech.Co., Ltd.
Tel
0512-58900862;0512-56727736
Fax
0086-512-56765862
Email
sales@alabiochem.com;sales@alabiochem.com
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China
ProdList
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Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
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China
ProdList
15424
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60
BOC Sciences
Tel
Email
info@bocsci.com
Country
United States
ProdList
9944
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T&W GROUP
Tel
021-61551611-
Fax
+86 21-50676805
Email
contact@trustwe.com
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China
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9646
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S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
17727448752;0755-83725681-603
Fax
+86 755 28094224
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China
ProdList
4508
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50
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399-
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4575
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55
AdooQ BioScience, LLC
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+1 (866) 930-6790
Fax
+1 (866) 333-9607
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info@adooq.com
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United States
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2773
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Jinan Mingya Medical Technology Co., Ltd.
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+86-531-85828981 18866807006
Fax
+86-531-85806006
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864598798@qq.com
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China
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588
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Shanghai JONLN Reagent Co., Ltd.
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400-0066400;021-60496031
Fax
021-55660885
Email
422131432@qq.com;422131432@qq.com
Country
China
ProdList
9998
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55

183506-66-3, APICIDINRelated Search:


  • Apicidin (OSI 2040)
  • APICIDIN, FUSARIUM SPECIES
  • Ccris 9163
  • Apicidin Ia
  • Cyclo(8-oxo-L-2-aMinodecanoyl-1-Methoxy-L-tryptophyl-L-isoleucyl- D-2-piperidinecarbonyl)
  • Cyclo[(2S)-2-aMino-8-oxodecanoyl-1-Methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl]
  • OSI 2040
  • Apicidin Cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl]
  • CYCLO-L-(2-AMINO-8-OXODEACANOYL)-L-(N-METHOXY-TRYPTOPHAN)-L-ISOLEUCYL-D-PIPECOLINYL
  • CYCLO-[L-(2-AMINO-8-OXODECANOYL)-L-(N-METHOXYTRYPTOPHAN)-L-ISOLEUCYL-D-PIPECOLINYL
  • CYCLO[(2S)-2-AMINO-8-OXODECANOYL-1-METHOXY-L-TRYPTOPHYL-L-ISOLEUCYL-(2R)-2-PIPERIDINEXCARBONYL]
  • APICIDIN
  • 183506-66-3
  • C34H49N5O6
  • Antibiotics A-F
  • Antibiotics A to Z
  • Antibiotics
  • BioChemical
  • antibiotic