ChemicalBook > CAS DataBase List > CAY10603

CAY10603

Product Name
CAY10603
CAS No.
1045792-66-2
Chemical Name
CAY10603
Synonyms
Isox;187257;BML-281;CAY10603;HDAC6 Inhibitor;CAY10603 ，S7596;CAY10603 CAY10603;HDAC6 inhibitor ISOX;CAY10603, 10 mM in DMSO;CAY10603; CAY-10603; CAY 10603.
CBNumber
CB42590439
Molecular Formula
C22H30N4O6
Formula Weight
446.5
MOL File
1045792-66-2.mol
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CAY10603 Property

Density 
1.231±0.06 g/cm3(Predicted)
storage temp. 
+2C to +8C
solubility 
≥22.35 mg/mL in DMSO; insoluble in EtOH; ≥24.85 mg/mL in H2O
form 
Beige to light brown solid
pka
9.47±0.20(Predicted)
color 
White to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
382175-M
Product name
Histone Deacetylase Inhibitor VIII
Purity
The Histone Deacetylase Inhibitor VIII, also referenced under CAS 1045792-66-2, controls the biological activity of Histone Deacetylase. This small molecule/inhibitor is primarily used for Cell Struc
Packaging
1 unit
Price
$195
Updated
2025/07/31
Cayman Chemical
Product number
13146
Product name
CAY10603
Purity
≥95%
Packaging
1mg
Price
$48
Updated
2024/03/01
Cayman Chemical
Product number
13146
Product name
CAY10603
Purity
≥95%
Packaging
5mg
Price
$176
Updated
2024/03/01
Cayman Chemical
Product number
13146
Product name
CAY10603
Purity
≥95%
Packaging
10mg
Price
$324
Updated
2024/03/01
Cayman Chemical
Product number
13146
Product name
CAY10603
Purity
≥95%
Packaging
25mg
Price
$578
Updated
2024/03/01
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CAY10603 Chemical Properties,Usage,Production

Description

Histone deacetylase 6 (HDAC6) is a class II HDAC that represses transcription by removing acetyl groups from histones. In addition, HDAC6 deacetylases tubulin, which is important in regulating microtubule stability and function. CAY10603 is a potent and selective inhibitor of HDAC6 (IC50 = 0.002 nM, as compared with 271, 252, 0.42, 6851, and 90.7 nM for HDAC1, 2, 3, 8, and 10, respectively). Also, CAY10603 prevents the growth of several pancreatic cancer cell lines (IC50 = 0.1-1 μM). The HDAC6 inhibitor is more active in inhibiting cell growth than the broad spectrum HDAC inhibitor suberoylanilide hydroxamic acid (SAHA).

Uses

HDAC6 Inhibitor is an inhibitor of HDAC6.

Definition

ChEBI: N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]-oxomethyl]-5-isoxazolyl]phenyl]carbamic acid tert-butyl ester is a carbamate ester.

General Description

A cell-permeable, active site Zn2+-targeting phenylisoxazolo-hydroxamate that acts a potent and highly selective HDAC6 inhibitor (IC50 = 0.002, 0.42, 90.7, 252, 271 and 6851 nM against HDAC-6, -3, -10, -2, -1 and -8, respectively). Shown to be more potent than SAHA in inhibiting the proliferation of a panel of pancreatic cancer cell lines (IC50<1.0 μM).

IC 50

HDAC6: 0.002 nM (IC50); HDAC3: 0.42 nM (IC50); HDAC10: 90.7 nM (IC50); HDAC2: 252 nM (IC50); HDAC1: 271 nM (IC50); HDAC8: 6851 nM (IC50)

References

[1] ALAN P. KOZIKOWSKI*. Use of the Nitrile Oxide Cycloaddition (NOC) Reaction for Molecular Probe Generation: A New Class of Enzyme Selective Histone Deacetylase Inhibitors (HDACIs) Showing Picomolar Activity at HDAC6[J]. Journal of Medicinal Chemistry, 2008, 51 15: 4370-4373. DOI: 10.1021/jm8002894

CAY10603 Preparation Products And Raw materials

Raw materials

Preparation Products

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1045792-66-2, CAY10603Related Search:

CarbaMic acid, N-(4-broMo-2-nitrophenyl)-, 1,1-diMethylethyl ester tert-butyl (4-chloro-3-fluoro-2-iodophenyl)carbamate tert-butyl (4-(phenylsulfonyl)benzyl)carbamate Sodium Butyrate Suberohydroxamic acid 1H-Benz[de]isoquinoline-2(3H)-butanamide SCRIPTAID SPLITOMICIN Sodium 4-phenylbutyrate BENZOTRIAZOL-1-YL-(2,4-DICHLORO-PHENYL)-METHANONE APICIDIN OXAMFLATIN HC TOXIN M344 Parthenolide ACY-1215 Imatinib Nexturastat A

  • CAY10603
  • Isox
  • tert-butyl 4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenylcarbamate
  • HDAC6 Inhibitor
  • N-[4-[3-[[[7-(Hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]carbamic acid 1,1-dimethylethyl ester
  • Histone Deacetylase Inhibitor VIII - CAS 1045792-66-2 - Calbiochem
  • CAY10603; CAY-10603; CAY 10603.
  • 187257
  • HDAC6 inhibitor ISOX
  • tert-butyl N-[4-[3-[[7-(hydroxyamino)-7-oxoheptyl]carbamoyl]-1,2-oxazol-5-yl]phenyl]carbamate
  • BML-281
  • Carbamic acid, N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]-, 1,1-dimethylethyl ester
  • BML 281,inhibit,Histone deacetylases,BML281,CAY-10603,Inhibitor,CAY10603,CAY 10603,HDAC
  • CAY10603 CAY10603
  • CAY10603, 10 mM in DMSO
  • Histone Deacetylase Inhibitor VIII
  • CAY10603 ，S7596
  • 1045792-66-2
  • Inhibitors