CAY10603
- Product Name
- CAY10603
- CAS No.
- 1045792-66-2
- Chemical Name
- CAY10603
- Synonyms
- Isox;187257;BML-281;CAY10603;HDAC6 Inhibitor;CAY10603 CAY10603;HDAC6 inhibitor ISOX;CAY10603; CAY-10603; CAY 10603.;Histone Deacetylase Inhibitor VIII - CAS 1045792-66-2 - Calbiochem;tert-butyl 4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenylcarbamate
- CBNumber
- CB42590439
- Molecular Formula
- C22H30N4O6
- Formula Weight
- 446.5
- MOL File
- 1045792-66-2.mol
CAY10603 Property
- Density
- 1.231±0.06 g/cm3(Predicted)
- storage temp.
- +2C to +8C
- solubility
- ≥22.35 mg/mL in DMSO; insoluble in EtOH; ≥24.85 mg/mL in H2O
- form
- Beige to light brown solid
- pka
- 9.47±0.20(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 13146
- Product name
- CAY10603
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $48
- Updated
- 2024/03/01
- Product number
- 13146
- Product name
- CAY10603
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $176
- Updated
- 2024/03/01
- Product number
- 13146
- Product name
- CAY10603
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $324
- Updated
- 2024/03/01
- Product number
- 13146
- Product name
- CAY10603
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $578
- Updated
- 2024/03/01
- Product number
- H999763
- Product name
- HDAC6Inhibitor
- Packaging
- 500μg
- Price
- $55
- Updated
- 2021/12/16
CAY10603 Chemical Properties,Usage,Production
Description
Histone deacetylase 6 (HDAC6) is a class II HDAC that represses transcription by removing acetyl groups from histones. In addition, HDAC6 deacetylases tubulin, which is important in regulating microtubule stability and function. CAY10603 is a potent and selective inhibitor of HDAC6 (IC50 = 0.002 nM, as compared with 271, 252, 0.42, 6851, and 90.7 nM for HDAC1, 2, 3, 8, and 10, respectively). Also, CAY10603 prevents the growth of several pancreatic cancer cell lines (IC50 = 0.1-
Uses
HDAC6 Inhibitor is an inhibitor of HDAC6.
Definition
ChEBI: N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]-oxomethyl]-5-isoxazolyl]phenyl]carbamic acid tert-butyl ester is a carbamate ester.
General Description
A cell-permeable, active site Zn2+-targeting phenylisoxazolo-hydroxamate that acts a potent and highly selective HDAC6 inhibitor (IC50 = 0.002, 0.42, 90.7, 252, 271 and 6851 nM against HDAC-6, -3, -10, -2, -1 and -8, respectively). Shown to be more potent than SAHA in inhibiting the proliferation of a panel of pancreatic cancer cell lines (IC50<1.0 μM).
CAY10603 Preparation Products And Raw materials
Raw materials
Preparation Products
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