ACY-1215
- Product Name
- ACY-1215
- CAS No.
- 1316214-52-4
- Chemical Name
- ACY-1215
- Synonyms
- ACY 63;CS-583;ACY-1215;Propane-1;Ricolinostat;Rocilinostat;ACY-1215/ACY1215;Rocilinostat, >=99%;3-tricarboxylic acid;β-Carboxyglutaric acid
- CBNumber
- CB82627292
- Molecular Formula
- C24H27N5O3
- Formula Weight
- 433.5
- MOL File
- 1316214-52-4.mol
ACY-1215 Property
- Melting point:
- 189 - 191°C
- Density
- 1.239±0.06 g/cm3(Predicted)
- storage temp.
- -20°C Freezer
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 9.47±0.20(Predicted)
- form
- Solid
- color
- White to Off-White
N-Bromosuccinimide Price
- Product number
- 21531
- Product name
- ACY-1215
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $72
- Updated
- 2024/03/01
- Product number
- 21531
- Product name
- ACY-1215
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $129
- Updated
- 2024/03/01
- Product number
- 21531
- Product name
- ACY-1215
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $228
- Updated
- 2024/03/01
- Product number
- 21531
- Product name
- ACY-1215
- Purity
- ≥98%
- Packaging
- 250mg
- Price
- $494
- Updated
- 2024/03/01
- Product number
- D486990
- Product name
- 2-(Diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide
- Packaging
- 250mg
- Price
- $275
- Updated
- 2021/12/16
ACY-1215 Chemical Properties,Usage,Production
Description
ACY-1215 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 5 nM). It is at least 10-fold less active against other HDACs in enzymatic assays. ACY-1215 shows synergistic activity with the proteasome inhibitor bortezomib against multiple myeloma (MM) cells, inducing protracted endoplasmic reticulum stress and apoptosis. ACY-1215 combined with proteasome inhibitors suppresses tumor growth and increases survival in mice with MM and mantle cell lymphoma xenografts. A multicenter phase I trial examining ACY-1215 combined with the E3 ligase inhibitor lenalidomide and dexamethasone in multiple myeloma found inhibition of HDAC6 in vivo. ACY-1215 also diminishes liver cyst development and fibrosis in a rat model of polycystic liver disease.
Uses
This compound acts as a selective HDAC-6 (histone deacetylase) inihibitor. HDAC is linked to the transcription of DNA in cancers, including multiple myeloma (MM).
Definition
ChEBI: N-[7-(hydroxyamino)-7-oxoheptyl]-2-(N-phenylanilino)-5-pyrimidinecarboxamide is a pyrimidinecarboxylic acid.
target
HDAC6
ACY-1215 Preparation Products And Raw materials
Raw materials
Preparation Products
ACY-1215 Suppliers
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View Lastest Price from ACY-1215 manufacturers
- Product
- ACY-1215 1316214-52-4
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000ton
- Release date
- 2023-08-29
- Product
- ACY-1215 1316214-52-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-13