Tubastatin A hydrochloride
- Product Name
- Tubastatin A hydrochloride
- CAS No.
- 1310693-92-5
- Chemical Name
- Tubastatin A hydrochloride
- Synonyms
- TSA HCl;CS-1894;Tubastatin A HCl salt;Tubastatin A HCl, >=98%;Tubastatin A hydrochloride;TUBASTATIN A HYDROCHLORIDE;TSA HCL;Tubastatin A HCl (AG-CR-13900, TubA);Tubastatin A hydrochloride ISO 9001：2015 REACH;Tubastatin A Hydrochloride (Also See: T897000);Tubastatin A HCl, 98%, a potent and selective HDAC6 inhibitor
- CBNumber
- CB32589694
- Molecular Formula
- C20H22ClN3O2
- Formula Weight
- 371.87
- MOL File
- 1310693-92-5.mol
Tubastatin A hydrochloride Property
- Melting point:
- >221°C (subl.)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO or Water.
- form
- powder
- color
- white to tan
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
Safety
- WGK Germany
- 3
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- SML0044
- Product name
- Tubastatin A hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $210
- Updated
- 2024/03/01
- Product number
- SML0044
- Product name
- Tubastatin A hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $805
- Updated
- 2024/03/01
- Product number
- T3687
- Product name
- Tubastatin A Hydrochloride
- Packaging
- 25MG
- Price
- $190
- Updated
- 2024/03/01
- Product number
- T3687
- Product name
- Tubastatin A Hydrochloride
- Packaging
- 100MG
- Price
- $580
- Updated
- 2024/03/01
- Product number
- 6270
- Product name
- Tubastatin A hydrochloride
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $126
- Updated
- 2021/12/16
Tubastatin A hydrochloride Chemical Properties,Usage,Production
Description
Tubastatin A (1310693-92-5) is a potent and highly selective inhibitor of HDAC6 (IC50?= 15 nM, >1000-fold selectivity against other HDAC isoforms, approx. 60-fold versus HDAC8).1?It displayed anti-inflammatory and anti-rheumatic effects in Freund’s competitive adjuvant induced animal model of inflammation.2?Tubastatin A inhibited TNF-α (IC50?= 272 nM) and IL-6 (IC50 = 712 nM) in LPS stimulated human THP-1 macrophages.2?Tubastatin A has also been shown to have therapeutic potential for treatment of Alzheimer’s disease via altered amyloid-β load and reduced tau hyperphosphorylation.3-5
Uses
Tubastatin A Hydrochloride is an LSD1 inhibitor, which targets SOX2-expressing cancer cells.
Uses
Tubastatin A Hydrochloride is a neuroprotective HDAC6 inhibitor and is also known to induce hyperacetylation in primary cortical neuron cultures.
Biochem/physiol Actions
Tubastatin A increases the total numbers of mitochondria and restores the number of moving mitochondria in DRG neurons. It reverses the axonal loss in peripheral neurons in mouse model of Charcot-Marie-Tooth disease. Tubastatin A inhibits the deacetylation of α-tubulin in murine myoblasts.
target
HDAC6
storage
Store at -20°C
References
1) Butler?et al. (2010),?Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A; J. Am. Chem. Soc.,?132?10842 2) Vishwakarma?et al. (2013),?Tubastatin, a selective histone deacetylase 6 inhibitor shows anti-inflammatory and anti-rheumatic effects; Int. Immunopharmacol.,?16?72 3) Noack and Richter-Landsberg (2014),?HDAC6 inhibition results in tau acetylation and modulates tau phosphorylation and degradation in oligodendrocytes; Glia,?62?535 4) Selenica?et al. (2014),?Histone deacetylase 6 inhibition improves memory and reduces total tau levels in a mouse model of tau deposition; Alzheimers Res.Ther.,?6?12 5) Zhang?et al. (2014)?Tubastatin A/ACY-1215 improves cognition in Alzheimer’s disease transgenic mice; J. Alzheimers Dis.,?41?1193
Tubastatin A hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Tubastatin A hydrochloride manufacturers
- Product
- Tubastatin A hydrochloride 1310693-92-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-09-28
- Product
- Tubastatin A HCl 1310693-92-5
- Price
- US $1.00/KG
- Min. Order
- 1g
- Purity
- Min98% HPLC
- Supply Ability
- g/kg /ton
- Release date
- 2019-12-20