ChemicalBook > CAS DataBase List > Tubastatin A hydrochloride

Tubastatin A hydrochloride

Product Name
Tubastatin A hydrochloride
CAS No.
1310693-92-5
Chemical Name
Tubastatin A hydrochloride
Synonyms
TSA HCl;CS-1894;Tubastatin A HCl salt;Tubastatin A HCl, >=98%;Tubastatin A hydrochloride;TUBASTATIN A HYDROCHLORIDE;TSA HCL;Tubastatin A HCl (AG-CR-13900, TubA);Tubastatin A hydrochloride ISO 9001：2015 REACH;Tubastatin A Hydrochloride (Also See: T897000);Tubastatin A HCl, 98%, a potent and selective HDAC6 inhibitor
CBNumber
CB32589694
Molecular Formula
C20H22ClN3O2
Formula Weight
371.87
MOL File
1310693-92-5.mol
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Tubastatin A hydrochloride Property

Melting point:
>221°C (subl.)
storage temp. 
-20°C
solubility 
Soluble in DMSO or Water.
form 
powder
color 
white to tan
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
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Safety

WGK Germany 
3
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0044
Product name
Tubastatin A hydrochloride
Purity
≥98% (HPLC)
Packaging
5mg
Price
$210
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0044
Product name
Tubastatin A hydrochloride
Purity
≥98% (HPLC)
Packaging
25mg
Price
$805
Updated
2024/03/01
TCI Chemical
Product number
T3687
Product name
Tubastatin A Hydrochloride
Packaging
25MG
Price
$190
Updated
2024/03/01
TCI Chemical
Product number
T3687
Product name
Tubastatin A Hydrochloride
Packaging
100MG
Price
$580
Updated
2024/03/01
Tocris
Product number
6270
Product name
Tubastatin A hydrochloride
Purity
≥98%(HPLC)
Packaging
10
Price
$126
Updated
2021/12/16
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Tubastatin A hydrochloride Chemical Properties,Usage,Production

Description

Tubastatin A (1310693-92-5) is a potent and highly selective inhibitor of HDAC6 (IC50?= 15 nM, >1000-fold selectivity against other HDAC isoforms, approx. 60-fold versus HDAC8).1?It displayed anti-inflammatory and anti-rheumatic effects in Freund’s competitive adjuvant induced animal model of inflammation.2?Tubastatin A inhibited TNF-α (IC50?= 272 nM) and IL-6 (IC50 = 712 nM) in LPS stimulated human THP-1 macrophages.2?Tubastatin A has also been shown to have therapeutic potential for treatment of Alzheimer’s disease via altered amyloid-β load and reduced tau hyperphosphorylation.3-5

Uses

Tubastatin A Hydrochloride is an LSD1 inhibitor, which targets SOX2-expressing cancer cells.

Uses

Tubastatin A Hydrochloride is a neuroprotective HDAC6 inhibitor and is also known to induce hyperacetylation in primary cortical neuron cultures.

Biochem/physiol Actions

Tubastatin A increases the total numbers of mitochondria and restores the number of moving mitochondria in DRG neurons. It reverses the axonal loss in peripheral neurons in mouse model of Charcot-Marie-Tooth disease. Tubastatin A inhibits the deacetylation of α-tubulin in murine myoblasts.

target

HDAC6

storage

Store at -20°C

References

1) Butler?et al. (2010),?Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A; J. Am. Chem. Soc.,?132?10842 2) Vishwakarma?et al. (2013),?Tubastatin, a selective histone deacetylase 6 inhibitor shows anti-inflammatory and anti-rheumatic effects; Int. Immunopharmacol.,?16?72 3) Noack and Richter-Landsberg (2014),?HDAC6 inhibition results in tau acetylation and modulates tau phosphorylation and degradation in oligodendrocytes; Glia,?62?535 4) Selenica?et al. (2014),?Histone deacetylase 6 inhibition improves memory and reduces total tau levels in a mouse model of tau deposition; Alzheimers Res.Ther.,?6?12 5) Zhang?et al. (2014)?Tubastatin A/ACY-1215 improves cognition in Alzheimer’s disease transgenic mice; J. Alzheimers Dis.,?41?1193

Tubastatin A hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Tubastatin A hydrochloride Suppliers

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View Lastest Price from Tubastatin A hydrochloride manufacturers

Dideu Industries Group Limited
Product
Tubastatin A hydrochloride 1310693-92-5
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-09-28
Career Henan Chemical Co
Product
Tubastatin A HCl 1310693-92-5
Price
US $1.00/KG
Min. Order
1g
Purity
Min98% HPLC
Supply Ability
g/kg /ton
Release date
2019-12-20

1310693-92-5, Tubastatin A hydrochlorideRelated Search:

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  • N-Hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide hydrochloride
  • Tubastatin A hydrochloride
  • TSA HCl
  • Tubastatin A Hydrochloride (Also See: T897000)
  • Tubastatin A HCl salt
  • N-hydroxy-4-((2-methyl-1,2,3,4-tetrahydropyrido[4,3-b]indol-5-yl)methyl)benzamide hydrochloride
  • N-Hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide hydrochloride Tubastatin A HCl
  • Tubastatin A hydrochloride N-Hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide hydrochloride
  • N-Hydroxy-4-((2-methyl-3,4-dihydro-1H-pyrido[4,3-b]-indol-5(2H)-yl)methyl)benzamide hydrochloride
  • N-Hydroxy-4-(2-methyl-1,2,3,4-tetrahydro-pyrido[4,3-b]indol-5-ylmethyl)benzamide hydrochloried
  • Tubastatin A HCl, >=98%
  • Tubastatin A HCl, 98%, a potent and selective HDAC6 inhibitor
  • TUBASTATIN A HYDROCHLORIDE;TSA HCL
  • CS-1894
  • N-Hydroxy-4-[(2-methyl-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5 -yl)methyl]benzamide hydrochloride (1:1)
  • Tubastatin A hydrochloride ISO 9001：2015 REACH
  • Tubastatin A HCl (AG-CR-13900, TubA)
  • N-Hydroxy-4-((2-methyl-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5-yl)methyl)benzamide hydrochloride
  • N-hydroxy-4-[(2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)methyl]benzamide
  • 1310693-92-5
  • C20H21N3O2HCl
  • Inhibitors