CX-4945
- Product Name
- CX-4945
- CAS No.
- 1009820-21-6
- Chemical Name
- CX-4945
- Synonyms
- CX-4945;CS-1985;Silmitasertib;CX-4945, >=98%;CX-4945, CX4945;mitasertib (CX-4945);SPIROBIINDANE CX-4945;Silmitasertib(CX-4945);CX-4945 Silmitasertib;CX-4945 Silmitasertib CX4945
- CBNumber
- CB62473893
- Molecular Formula
- C19H12ClN3O2
- Formula Weight
- 349.77
- MOL File
- 1009820-21-6.mol
CX-4945 Property
- Boiling point:
- 568.5±50.0 °C(Predicted)
- Density
- 1.490
- storage temp.
- Store at -20°C
- solubility
- ≥103.5 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
- form
- Orange powder.
- pka
- 2.96±0.30(Predicted)
- color
- Yellow to orange
- InChI
- InChI=1S/C19H12ClN3O2/c20-12-2-1-3-13(9-12)22-18-15-6-7-21-10-16(15)14-5-4-11(19(24)25)8-17(14)23-18/h1-10H,(H,22,23)(H,24,25)
- InChIKey
- MUOKSQABCJCOPU-UHFFFAOYSA-N
- SMILES
- C1(NC2=CC=CC(Cl)=C2)C2=C(C=NC=C2)C2=CC=C(C(O)=O)C=C2N=1
Safety
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 16779
- Product name
- CX-4945
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 16779
- Product name
- CX-4945
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 16779
- Product name
- CX-4945
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $206
- Updated
- 2024/03/01
- Product number
- 16779
- Product name
- CX-4945
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $346
- Updated
- 2024/03/01
- Product number
- C858600
- Product name
- CX-4945
- Packaging
- 50mg
- Price
- $910
- Updated
- 2021/12/16
CX-4945 Chemical Properties,Usage,Production
Uses
CX-4945 is a protein kinase CK2 inhibitor resulting in cancer cell death and prevention of proliferation. Anti-leukemia agent.
Biological Activity
cx-4945 (silmitasertib) is a potent and selective casein kinase 2 (ck2) inhibitor with ic50 value of 1 nm. it is atp-competitive and can be taken orally [1].cx-4945 has been reported to have antiproliferative activity against a wide range of tumor cell lines. it is suggested that cx-4945 suppresses the ck2 regulated pi3k/akt signaling pathway by inhibiting akt phosphorylation at serine 129, but not by activating pten. additionally, cells treated with cx-4945 had a reduction of p21 phophorylation and an up-regulations of total p21 and p27. cx-4945 has been shown to induce cell-cycle arrest at g2/m phase in breast cancer cell line bt-474. it also causes cell-cycle arrest at g1 phase the breast cancer cell line bxpc-3) [1].in cx-4945 and bxpc-3 derived mouse xenograft model, cx-4945 induced a reduction of phos-p21 expression along with anti-carcinoma effects [1]
in vivo
Silmitasertib (CX-4945) (25 or 75 mg/kg, p.o.) is well tolerated and demonstrated robust antitumor activity with concomitant reductions of the mechanism-based biomarker phospho-p21 (T145) in murine xenograft models[1].
IC 50
CK2α: 1 nM (IC50); CK2α': 1 nM (IC50)
References
[1] siddiqui-jain a1, drygin d, streiner n, chua p, pierre f, o'brien se, bliesath j, omori m, huser n, ho c, proffitt c, schwaebe mk, ryckman dm, rice wg,anderes k. cx-4945, an orally bioavailable selective inhibitor of protein kinase ck2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy. cancer res. 2010 dec 15; 70 (24): 10288-98.
CX-4945 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from CX-4945 manufacturers
- Product
- 5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylic acid 1009820-21-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2019-12-23