CX-4945

Product Name: CX-4945
CAS No.: 1009820-21-6
Chemical Name: CX-4945
Synonyms: CX-4945;CS-1985;Silmitasertib;CX-4945, >=98%;CX-4945, CX4945;mitasertib (CX-4945);Silmitasertib(CX-4945);CX-4945 Silmitasertib;SILMITASERTIB; CX 4945; CX4945;4-di-tert-butylphenyl)phosphate
CBNumber: CB62473893
Molecular Formula: C19H12ClN3O2
Formula Weight: 349.77
MOL File: 1009820-21-6.mol

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CX-4945 Property

Boiling point:: 568.5±50.0 °C(Predicted)
Density: 1.490
solubility: ≥103.5 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form: Orange powder.
pka: 2.96±0.30(Predicted)

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Safety

HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16779
Product name: CX-4945
Purity: ≥98%
Packaging: 500μg
Price: $54
Updated: 2023/01/06

Cayman Chemical

Product number: 16779
Product name: CX-4945
Purity: ≥98%
Packaging: 1mg
Price: $96
Updated: 2023/01/06

Cayman Chemical

Product number: 16779
Product name: CX-4945
Purity: ≥98%
Packaging: 5mg
Price: $182
Updated: 2023/01/06

Cayman Chemical

Product number: 16779
Product name: CX-4945
Purity: ≥98%
Packaging: 10mg
Price: $308
Updated: 2023/01/06

TRC

Product number: C858600
Product name: CX-4945
Packaging: 50mg
Price: $910
Updated: 2021/12/16

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CX-4945 Chemical Properties,Usage,Production

Uses

CX-4945 is a protein kinase CK2 inhibitor resulting in cancer cell death and prevention of proliferation. Anti-leukemia agent.

Biological Activity

cx-4945 (silmitasertib) is a potent and selective casein kinase 2 (ck2) inhibitor with ic50 value of 1 nm. it is atp-competitive and can be taken orally [1].cx-4945 has been reported to have antiproliferative activity against a wide range of tumor cell lines. it is suggested that cx-4945 suppresses the ck2 regulated pi3k/akt signaling pathway by inhibiting akt phosphorylation at serine 129, but not by activating pten. additionally, cells treated with cx-4945 had a reduction of p21 phophorylation and an up-regulations of total p21 and p27. cx-4945 has been shown to induce cell-cycle arrest at g2/m phase in breast cancer cell line bt-474. it also causes cell-cycle arrest at g1 phase the breast cancer cell line bxpc-3) [1].in cx-4945 and bxpc-3 derived mouse xenograft model, cx-4945 induced a reduction of phos-p21 expression along with anti-carcinoma effects [1]

References

[1] siddiqui-jain a1, drygin d, streiner n, chua p, pierre f, o'brien se, bliesath j, omori m, huser n, ho c, proffitt c, schwaebe mk, ryckman dm, rice wg,anderes k. cx-4945, an orally bioavailable selective inhibitor of protein kinase ck2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy. cancer res. 2010 dec 15; 70 (24): 10288-98.

CX-4945 Preparation Products And Raw materials

Raw materials

Preparation Products

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CX-4945 Suppliers

China 127 India 2 United Kingdom 1 United States 17 Global 147

Lancrix Chemicals

Tel: 86-21-50817262
Fax: 86-21-57712035
Email: sales@lancrix.com
Country: China
ProdList: 1503
Advantage: 55

Wuxi KaideRui Pharmaceutical Technology Co., Ltd

Tel: 15370852968
Fax: -
Email: 1557216087@qq.com
Country: China
ProdList: 1945
Advantage: 55

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 1913
Advantage: 55

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2923
Advantage: 55

Chembest Research Laboratories Limited

Tel: 021-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6002
Advantage: 61

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9986
Advantage: 60

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10194
Advantage: 62

WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

Tel: 027-65522453
Email: sales@sun-shinechem.com
Country: China
ProdList: 296
Advantage: 64

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 19984
Advantage: 64

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7815
Advantage: 57

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View Lastest Price from CX-4945 manufacturers

Career Henan Chemical Co

Product: 5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylic acid 1009820-21-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2019-12-23

1009820-21-6, CX-4945Related Search:

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5-[(3-chlorophenyl)amino]-Benzo[c]-2,6-naphthyridine-8-carboxylic acid

CX-4945

Silmitasertib

CX-4945 Silmitasertib

CX-4945, CX4945

Silmitasertib(CX-4945)

5-[(3-Chlorophenyl)amino]benzo[c]-2,6-naphthyridine-8-carboxylic acid CX-4945 (Silmitasertib)

CX-4945, >=98%

CX-4945 (SILMITASERTIB);CX 4945; CX4945

Silmitasertib, 98%, a potent and selective ATP-competitive CK2 inhibitor

CX4945 CX-4945; CX 4945; SILMITASERTIB.

CS-1985

SILMITASERTIB; CX 4945; CX4945

mitasertib (CX-4945)

Benzo[c]-2,6-naphthyridine-8-carboxylic acid, 5-[(3-chlorophenyl)amino]-

4-di-tert-butylphenyl)phosphate

CX-4945 5-[(3-chlorophenyl)amino]-Benzo[c]-2,6-naphthyridine-8-carboxylic

1009820-21-6

Inhibitors