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CX-4945

Product Name
CX-4945
CAS No.
1009820-21-6
Chemical Name
CX-4945
Synonyms
CX-4945;CS-1985;Silmitasertib;CX-4945, >=98%;CX-4945, CX4945;mitasertib (CX-4945);Silmitasertib(CX-4945);CX-4945 Silmitasertib;SILMITASERTIB; CX 4945; CX4945;4-di-tert-butylphenyl)phosphate
CBNumber
CB62473893
Molecular Formula
C19H12ClN3O2
Formula Weight
349.77
MOL File
1009820-21-6.mol
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CX-4945 Property

Boiling point:
568.5±50.0 °C(Predicted)
Density 
1.490
solubility 
≥103.5 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form 
Orange powder.
pka
2.96±0.30(Predicted)
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Safety

HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16779
Product name
CX-4945
Purity
≥98%
Packaging
500μg
Price
$54
Updated
2023/01/06
Cayman Chemical
Product number
16779
Product name
CX-4945
Purity
≥98%
Packaging
1mg
Price
$96
Updated
2023/01/06
Cayman Chemical
Product number
16779
Product name
CX-4945
Purity
≥98%
Packaging
5mg
Price
$182
Updated
2023/01/06
Cayman Chemical
Product number
16779
Product name
CX-4945
Purity
≥98%
Packaging
10mg
Price
$308
Updated
2023/01/06
TRC
Product number
C858600
Product name
CX-4945
Packaging
50mg
Price
$910
Updated
2021/12/16
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CX-4945 Chemical Properties,Usage,Production

Uses

CX-4945 is a protein kinase CK2 inhibitor resulting in cancer cell death and prevention of proliferation. Anti-leukemia agent.

Biological Activity

cx-4945 (silmitasertib) is a potent and selective casein kinase 2 (ck2) inhibitor with ic50 value of 1 nm. it is atp-competitive and can be taken orally [1].cx-4945 has been reported to have antiproliferative activity against a wide range of tumor cell lines. it is suggested that cx-4945 suppresses the ck2 regulated pi3k/akt signaling pathway by inhibiting akt phosphorylation at serine 129, but not by activating pten. additionally, cells treated with cx-4945 had a reduction of p21 phophorylation and an up-regulations of total p21 and p27. cx-4945 has been shown to induce cell-cycle arrest at g2/m phase in breast cancer cell line bt-474. it also causes cell-cycle arrest at g1 phase the breast cancer cell line bxpc-3) [1].in cx-4945 and bxpc-3 derived mouse xenograft model, cx-4945 induced a reduction of phos-p21 expression along with anti-carcinoma effects [1]

References

[1] siddiqui-jain a1, drygin d, streiner n, chua p, pierre f, o'brien se, bliesath j, omori m, huser n, ho c, proffitt c, schwaebe mk, ryckman dm, rice wg,anderes k. cx-4945, an orally bioavailable selective inhibitor of protein kinase ck2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy. cancer res. 2010 dec 15; 70 (24): 10288-98.

CX-4945 Preparation Products And Raw materials

Raw materials

Preparation Products

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CX-4945 Suppliers

Lancrix Chemicals
Tel
86-21-50817262
Fax
86-21-57712035
Email
sales@lancrix.com
Country
China
ProdList
1503
Advantage
55
Wuxi KaideRui Pharmaceutical Technology Co., Ltd
Tel
15370852968
Fax
-
Email
1557216087@qq.com
Country
China
ProdList
1945
Advantage
55
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
1913
Advantage
55
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2923
Advantage
55
Chembest Research Laboratories Limited
Tel
021-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6002
Advantage
61
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9986
Advantage
60
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10194
Advantage
62
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
Tel
027-65522453
Email
sales@sun-shinechem.com
Country
China
ProdList
296
Advantage
64
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19984
Advantage
64
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7815
Advantage
57
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View Lastest Price from CX-4945 manufacturers

Career Henan Chemical Co
Product
5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylic acid 1009820-21-6
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2019-12-23

1009820-21-6, CX-4945Related Search:


  • 5-[(3-chlorophenyl)amino]-Benzo[c]-2,6-naphthyridine-8-carboxylic acid
  • CX-4945
  • Silmitasertib
  • CX-4945 Silmitasertib
  • CX-4945, CX4945
  • Silmitasertib(CX-4945)
  • 5-[(3-Chlorophenyl)amino]benzo[c]-2,6-naphthyridine-8-carboxylic acid CX-4945 (Silmitasertib)
  • CX-4945, >=98%
  • CX-4945 (SILMITASERTIB);CX 4945; CX4945
  • Silmitasertib, 98%, a potent and selective ATP-competitive CK2 inhibitor
  • CX4945 CX-4945; CX 4945; SILMITASERTIB.
  • CS-1985
  • SILMITASERTIB; CX 4945; CX4945
  • mitasertib (CX-4945)
  • Benzo[c]-2,6-naphthyridine-8-carboxylic acid, 5-[(3-chlorophenyl)amino]-
  • 4-di-tert-butylphenyl)phosphate
  • CX-4945 5-[(3-chlorophenyl)amino]-Benzo[c]-2,6-naphthyridine-8-carboxylic
  • 1009820-21-6
  • Inhibitors