ChemicalBook > CAS DataBase List > KU-55933

KU-55933

Product Name
KU-55933
CAS No.
587871-26-9
Chemical Name
KU-55933
Synonyms
CS-63;U-55933;KV-55933;KU 55933 NEW;KU-55933, >99%;KU 55933, >=98%;KU55933; KU 55933;KU-55933 USP/EP/BP;ATM Kinase Inhibitor;KU-55933 (ATM Kinase Inhibitor)
CBNumber
CB8503709
Molecular Formula
C21H17NO3S2
Formula Weight
395.49
MOL File
587871-26-9.mol
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KU-55933 Property

Boiling point:
628.0±55.0 °C(Predicted)
Density 
1.419±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml)
form 
powder
pka
0.33±0.20(Predicted)
color 
white to beige
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1109
Product name
KU-55933
Purity
≥98% (HPLC)
Packaging
5MG
Price
$100
Updated
2023/01/07
Sigma-Aldrich
Product number
SML1109
Product name
KU-55933
Purity
≥98% (HPLC)
Packaging
25MG
Price
$407
Updated
2023/01/07
Cayman Chemical
Product number
16336
Product name
Ku-55933
Purity
≥98%
Packaging
1mg
Price
$50
Updated
2023/01/06
Cayman Chemical
Product number
16336
Product name
Ku-55933
Purity
≥98%
Packaging
5mg
Price
$71
Updated
2023/01/06
Cayman Chemical
Product number
16336
Product name
Ku-55933
Purity
≥98%
Packaging
10mg
Price
$123
Updated
2023/01/06
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KU-55933 Chemical Properties,Usage,Production

Description

Potent and selective ATM kinase inhibitor IC50s= 13, 2500, 9300, 16600, >100000 and >100000 nM for ATM, DNA-PK, mTOR, PI 3-kinase, PI 4-K and ATR respectively.1Decreases viability of MCF-7, A549 and HCT116 cells and decreases p21CIP1?levels?in vitro.2?Disruption of ATM signaling in primary A-T fibroblasts leads to dysregulation of ribonucleotide reductase and increase resistance to inhibitors of mitochondrial respiration and translation.3?Sensitizes radio-resistant cancer cells.4Provides neuroprotection against H2O2-induced cell damage.5

Uses

A potent and specific ATM kinase inhibitor with an IC50 and a Ki of 13 nM and 2.2 nM, respectively.

Uses

KU-55933 has been used as an ataxia-telangiectasia mutated (Atm) inhibitor.

Biological Activity

Potent, selective and competitive ATM kinase inhibitor (K i = 2.2 nM, IC 50 values are 13, 2500, 9300, 16600, > 100000 and > 100000 nM at ATM, DNA-PK, mTOR, PI 3-kinase, PI 4-K and ATR respectively). Decreases viability of MCF-7, A549 and HCT116 cells and decreases p21 CIP1 levels in vitro . Acts as a radio- and chemosensitizer for the treatment of cancer.

Biochem/physiol Actions

KU-55933 is a very potent, specific inhibitor of Ataxia telangiectasia (A-T) mutated (ATM) kinase (IC50 = 13 nM). KU-22933 treatment sensitizes cancer cells to ionizing radiation and cytotoxic drugs. The compound KU-22933 blocks ATM-mediated phosphorylyation of p53, gH2AX, NBS1, and SMC1.

References

1) Hickson?et al.?(2004),?Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM; Cancer Res.,?64?9152 2) Crescenzi?et al.?(2008),?Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: implications for chemotherapy; Clin. Cancer Res.?14?1877 3) Eaton?et al.?(2007),?Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasis; J. Clin. Invest.,?117?2723 4) Zhang?et al.?(2015)?The ATM inhibitor KU55933 sensitizes radioresistant bladder cancer cells with DAB2IP gene defect; Int. J. Radiat. Biol.,?91?368 5) Chwastek?et al.?(2017)?The ATM kinase inhibitor KU-55933 provides neuroprotection against hydrogen peroxide-induced cell damage via a yH2AX/p-p53/caspase-3-independent mechanism: Inhibition of calpain and cathepsin D; Int. J. Biochem. Cell Biol.?87?38

KU-55933 Preparation Products And Raw materials

Raw materials

Preparation Products

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KU-55933 Suppliers

Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2923
Advantage
55
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15861
Advantage
69
Chembest Research Laboratories Limited
Tel
021-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6002
Advantage
61
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9986
Advantage
60
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15421
Advantage
60
Jinan Trio PharmaTech Co., Ltd.
Tel
+86 (531) 88811783
Fax
+86 (531) 55696010 QQ 1762738062
Email
sales@trio-pharmatech.com (International market)
Country
China
ProdList
1856
Advantage
62
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4858
Advantage
58
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9873
Advantage
52
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12338
Advantage
58
NCE Biomedical Co.,Ltd.
Tel
4000-027-021 |24 hour enquiry :+86-13986109188 |English:+86-15623472865 |Japanese:+81-08033611988
Fax
+86-27-87599188
Country
China
ProdList
1494
Advantage
55
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View Lastest Price from KU-55933 manufacturers

Wuhan Nutra Biotechnology Co.,Ltd
Product
KU55933;ku-55933 587871-26-9
Price
US $0.00-0.00/g
Min. Order
1g
Purity
98%+
Supply Ability
10kgs
Release date
2021-05-24
Career Henan Chemical Co
Product
KU-55933 587871-26-9
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-23

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