ChemicalBook > CAS DataBase List > 3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide

3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide

Product Name
3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide
CAS No.
1232410-49-9
Chemical Name
3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide
Synonyms
VE-821;AVE821;CS-634;VE821;VE 821;ATR Inhibitor IV;VE-821;VE821;VE 821;3-Amino-6-[4-(methlsulfonyl)phenyl)-N-phenyl-2-pyrazinecarboxamide;3-Amino-6-(4-methanesulfonylphenyl)-N-phenylpyrazine-2-carboxamide;3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide;3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide
CBNumber
CB52534719
Molecular Formula
C18H16N4O3S
Formula Weight
368.41
MOL File
1232410-49-9.mol
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3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide Property

Melting point:
247-249°C
Boiling point:
568.4±50.0 °C(Predicted)
Density 
1.394
storage temp. 
-20°C
solubility 
Soluble in DMSO (40 mg/ml)
pka
9.97±0.70(Predicted)
form 
powder
color 
white to beige
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1415
Product name
VE-821
Purity
≥98% (HPLC)
Packaging
5MG
Price
$115
Updated
2023/01/07
Sigma-Aldrich
Product number
SML1415
Product name
VE-821
Purity
≥98% (HPLC)
Packaging
25MG
Price
$451
Updated
2023/01/07
Sigma-Aldrich
Product number
5.04972
Product name
ATR Inhibitor IV - CAS 1232410-49-10 - Calbiochem
Packaging
10mg
Price
$246
Updated
2023/01/07
Cayman Chemical
Product number
17587
Product name
VE-821
Purity
≥98%
Packaging
1mg
Price
$28
Updated
2023/01/06
Cayman Chemical
Product number
17587
Product name
VE-821
Purity
≥98%
Packaging
5mg
Price
$102
Updated
2023/01/06
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3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide Chemical Properties,Usage,Production

Description

Ataxia-telangiectasia and Rad3-related protein (ATR) is a serine/threonine kinase that activates DNA processes related to the DNA damage response. VE-821 is an ATP-competitive inhibitor of ATR (IC50 = 26 nM). It augments DNA damage and cell death of cancer cells in response to radiation under normal and hypoxic conditions. VE-821 also sensitizes cancer cells to chemotherapy.

Chemical Properties

Bright Yellow Solid

Uses

VE 821 is a potent and selective inhibitor of DNA damage response kinase, ATR. VE 821 functions to disrupt DNA damage repair system of tumor cells, limiting their abilities for further growth.

Uses

VE-821 has been used as an inhibitor of ATM- and Rad3-related (ATR) protein in human cancer cells.

Biochem/physiol Actions

VE-821 is a potent ATP-competitive inhibitor of the DNA damage response (DDR) kinase Ataxia telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) with a Ki of 13 nM. VE-821 has minimal cross-reactivity against the related PIKKs ATM, DNA-dependent protein kinase (DNA-PK), mTOR and PI3-kinase-γ (Ki of 16 μM, 2.2 μM, >1 μM and 3.9 μM, respectively) and against a large panel of unrelated protein kinases. VE-821 used alone caused death in a large fraction of cancer cell populations and also showed strong synergy with genotoxic agents. VE-821 increased sensitivity of cells to radiation and also sensitized cancer cells to a variety of chemotherapeutic agents.

References

Reaper et al. (2011), Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR; Nat. Chem. Biol., 7 428 Prevo et al. (2012), The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy; Cancer Biol. Ther., 13 1072 Huntoon et al. (2013), ATR inhibition broadly sensitizes ovarian cancer cells to chemotherapy independent of BRCA status; Cancer Res., 73 3683 King et al. (2021), Increased Replication Stress Determines ATR Inhibitor Sensitivity in Neuroblastoma Cells; Cancers (Basel), 13 6215 Moolmuang and Ruchirawat (2021), The antiproliferative effects of ataxia-telangiectasia mutated and ATM- and Rad3-related inhibitions and their enhancements with the cytotoxicity of DNA damaging agents in cholangiocarcinoma cells; J. Pharm. Pharmacol., 73 40

3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide Suppliers

Shanghai Boyle Chemical Co., Ltd.
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Fax
86-21-57758967
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sales@boylechem.com
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China
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2923
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J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
Fax
86-10-82849933
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jkinfo@jkchemical.com
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China
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Chembest Research Laboratories Limited
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021-20908456
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021-58180499
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sales@BioChemBest.com
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China
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BeiJing Hwrk Chemicals Limted
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0757-86329057 18516978288
Fax
010-89508210
Email
sales.gd@hwrkchemical.com
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China
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Chemsky(shanghai)International Co.,Ltd.
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021-50135380
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shchemsky@sina.com
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China
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Jinan Trio PharmaTech Co., Ltd.
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+86 (531) 88811783
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+86 (531) 55696010 QQ 1762738062
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sales@trio-pharmatech.com (International market)
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China
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Shanghai Feibo Chemical Technology Co., Ltd
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15921236618
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blinkzeng@gmail.com
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China
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Dalian Meilun Biotech Co., Ltd.
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0411-62910999 13889544652
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sales@meilune.com
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China
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Haoyuan Chemexpress Co., Ltd.
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021-58950125
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(86) 21-58955996
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info@chemexpress.com
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China
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Candia Thamtech Company Limited
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0371-86615086 18203638366 0371-86159066 13526786601
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0371-86159066
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China
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2017
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View Lastest Price from 3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide manufacturers

Career Henan Chemical Co
Product
3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide 1232410-49-9
Price
US $1.00/KG
Min. Order
1G
Purity
98%
Supply Ability
100KG
Release date
2018-08-21

1232410-49-9, 3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamideRelated Search:


  • VE-821;VE821;VE 821
  • 3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide
  • 2-Pyrazinecarboxamide, 3-amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-
  • 3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide VE-821
  • VE-821 3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide
  • VE821;VE 821
  • CS-634
  • 3-Amino-6-[4-(methlsulfonyl)phenyl)-N-phenyl-2-pyrazinecarboxamide
  • VE-821
  • 3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide
  • AVE821
  • ATR Inhibitor IV
  • 3-Amino-6-(4-methanesulfonylphenyl)-N-phenylpyrazine-2-carboxamide
  • 3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide USP/EP/BP
  • 1232410-49-9
  • Inhibitors
  • API