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NORFLUOXETINE HYDROCHLORIDE

Product Name
NORFLUOXETINE HYDROCHLORIDE
CAS No.
57226-68-3
Chemical Name
NORFLUOXETINE HYDROCHLORIDE
Synonyms
NORFLUOXETINE HCL;Fluoxetine EP Impurity H;NORFLUOXETINE HYDROCHLORIDE;Fluoxetine Impurity 8(EP-H);Norfluoxetine hydrochloride in methanol;Norfluoxetine Hydrochloride Solution, 100ppm;Fluoxetine Impurity 8(Fluoxetine EP Impurity H);Norfluoxetine hydrochloride (Desmethylfluoxetine);Norfluoxetine.HCl, 1mg/ml in Methanol (as free base);3-PHENYL-3-(4-TRIFLUOROMETHYL-PHENOXY)-PROPYLAMINE HYDROCHLORIDE
CBNumber
CB1112230
Molecular Formula
C16H17ClF3NO
Formula Weight
331.76
MOL File
57226-68-3.mol
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NORFLUOXETINE HYDROCHLORIDE Property

storage temp. 
-20°C
solubility 
H2O: >4 mg/mL
form 
solid
color 
yellow
Water Solubility 
H2O: >4mg/mL
DMSO: >5mg/mL
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
15900
Product name
Norfluoxetine (hydrochloride)
Packaging
1mg
Price
$45
Updated
2024/03/01
Cayman Chemical
Product number
15900
Product name
Norfluoxetine (hydrochloride)
Packaging
10mg
Price
$277
Updated
2024/03/01
Cayman Chemical
Product number
15900
Product name
Norfluoxetine (hydrochloride)
Packaging
5mg
Price
$198
Updated
2024/03/01
TRC
Product number
N681100
Product name
Norfluoxetine hydrochloride
Packaging
2mg
Price
$100
Updated
2021/12/16
AK Scientific
Product number
4422AJ
Product name
Norfluoxetine hydrochloride
Packaging
5mg
Price
$98
Updated
2021/12/16
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NORFLUOXETINE HYDROCHLORIDE Chemical Properties,Usage,Production

Description

Norfluoxetine is an active metabolite of the antidepressant fluoxetine. It is formed from fluoxetine by the cytochrome P450 (CYP) isoforms CYP2C9, CYP2C19, and CYP3A. Norfluoxetine inhibits serotonin (5-HT) uptake in rat brain synaptosomal membrane preparations (Ki = 44.7 nM) and isolated human platelets (IC50 = ~15 nM). It has been found in the tissues of fish exposed to wastewater effluent.

Chemical Properties

NORFLUOXETINE HYDROCHLORIDE is Light Beige to Light Brown Solid

Uses

Norfluoxetine Hydrochloride is a metabolite of Fluoxetine (F597100), a selective serotonin reuptake inhibitor which is used as an antidepressant.

Uses

Norfluoxetine hydrochloride has been used to examine if psychoactive pharmaceuticals in drinking water at environmental concentrations could induce neuronal gene expression. It has also been used to examine whether at environmental concentrations it can alter in vitro expression of autism spectrum disorders (ASD)-associated synaptic proteins in human neurons.

Biochem/physiol Actions

Norfluoxetine is an active metabolite of fluoxetine. It disturbs the production of estrogen in a co-culture model of the feto-placental unit.

in vivo

Pretreatment with Fluoxetine or Norfluoxetine hydrochloride (20mg/kg s.c.), as well as Phenytoin (30 mg/kg s.c.) and Clonazepam (0.1mg/kg s.c.) significantly increases both the rate and duration of survival, demonstrating a significant protective effect against Pentylenetetrazol-induced epilepsy[1].

IC 50

5-HT Receptor; CaV3.3: 5 μM (IC50)

References

[1] CHRISTIAAN C VEERMAN. Slow delayed rectifier potassium current blockade contributes importantly to drug-induced long QT syndrome.[J]. Circulation. Arrhythmia and electrophysiology, 2013, 6 5: 1002-1009. DOI:10.1161/circep.113.000239
[2] JUSTIN D LUTZ. Stereoselective inhibition of CYP2C19 and CYP3A4 by fluoxetine and its metabolite: implications for risk assessment of multiple time-dependent inhibitor systems.[J]. Drug Metabolism and Disposition, 2013, 41 12: 2056-2065. DOI:10.1124/dmd.113.052639
[3] DAVID T. WONG PH.D. Norfluoxetine Enantiomers as Inhibitors of Serotonin Uptake in Rat Brain[J]. Neuropsychopharmacology, 1993, 8 4: 337-344. DOI:10.1038/npp.1993.33
[4] JUN ZUO. Fluoxetine is a potent inhibitor of coxsackievirus replication.[J]. Antimicrobial Agents and Chemotherapy, 2012, 56 9: 4838-4844. DOI:10.1128/aac.00983-12
[5] CONOR MCCLENAGHAN. Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states.[J]. Journal of General Physiology, 2016, 147 6: 497-505. DOI:10.1085/jgp.201611601

NORFLUOXETINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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NORFLUOXETINE HYDROCHLORIDE Suppliers

Canada 3 China 59 India 3 Switzerland 1 United States 12 Global 78
J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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86-10-82849933
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jkinfo@jkchemical.com
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Chemsky（shanghai）International Co.,Ltd.
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021-50135380
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shchemsky@sina.com
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Cato Research Chemicals Inc.
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Sigma-Aldrich
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Alfa Chemistry
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JW & Y Pharmlab Co., Ltd.
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BOC Sciences
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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021-65675885
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Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
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Amadis Chemical Company Limited
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571-89925085
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0086-571-89925065
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sales@amadischem.com
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57226-68-3, NORFLUOXETINE HYDROCHLORIDERelated Search:

Meta Fluoxetine Hydrochloride LXNAWNZZEQJKCC-UHFFFAOYSA-N N-Methyl-3-phenylpropan-1-aMine hydrochloride (RelCpd B) N-METHYL-3-CHLOROPROPYLAMINE HYDROCHLORIDE NORFLUOXETINE HYDROCHLORIDE FLUOXETINE HYDROCHLORIDE Bispyridoxine (3RS)-N-Methyl-3-phenyl-3-[2-(trifluoroMethyl)-phenoxy]propan-1-aMine Hydrochloride(2-TrifluoroMethylisoMer of Fluoxetine Hydro-chloride) 3-Dechloro-3-broMo Trazodone Hydrochloride Thioridazine-d3 Hydrochloride 4-Chlorobenzotrichloride Fluoxetine-D5 hydrochloride 3-dimethylamino-1-phenyl-propan-1-ol 3-(DIMETHYLAMINO)-1-PHENYLPROPAN-1-ONE 3-Chlorobenzotrifluoride 4-Trifluoromethylphenol 1-Phenyl-2-propen-1-one Fluoxetine Impurity 29

  • NORFLUOXETINE HCL
  • NORFLUOXETINE HYDROCHLORIDE
  • (+/-)-GAMMA-[4-(TRIFLUOROMETHYL)PHENOXY]-BENZENEPROPANAMINE HYDROCHLORIDE
  • 3-PHENYL-3-(4-TRIFLUOROMETHYL-PHENOXY)-PROPYLAMINE HYDROCHLORIDE
  • 3-[4-(TRIFLUOROMETHYL)PHENOXY]-3-PHENYLPROPAN-1-AMINE HYDROCHLORIDE
  • Benzenepropanamine, gamma-(4-(trifluoromethyl)phenoxy)-, hydrochloride
  • 1-(3-Amino-1-phenylpropoxy)-4-(trifluoromethyl)benzene hydrochloride
  • Norfluoxetine Hydrochloride Solution, 100ppm
  • Fluoxetine Impurity 8(EP-H)
  • Fluoxetine EP Impurity H
  • Norfluoxetine hydrochloride (Desmethylfluoxetine)
  • Ca channels,P450,reuptake,Fluoxetine,Norfluoxetine Hydrochloride,CaV3.3,Inhibitor,anticonvulsant,inhibit,CYP2C19,5-HT,N-demethylated,serotonin,Serotonin Receptor,Ca2+ channels,CYP3A4,5-hydroxytryptamine Receptor,Drug Metabolite,Calcium Channel,metabolite,CYP2D6,5-HT Receptor,Norfluoxetine
  • Fluoxetine Impurity 8(Fluoxetine EP Impurity H)
  • Norfluoxetine hydrochloride in methanol
  • Norfluoxetine.HCl, 1mg/ml in Methanol (as free base)
  • 57226-68-3