NORFLUOXETINE HYDROCHLORIDE

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NORFLUOXETINE HYDROCHLORIDE

Product Name: NORFLUOXETINE HYDROCHLORIDE
CAS No.: 57226-68-3
Chemical Name: NORFLUOXETINE HYDROCHLORIDE
Synonyms: NORFLUOXETINE HCL;Fluoxetine EP Impurity H;NORFLUOXETINE HYDROCHLORIDE;Fluoxetine Impurity 8(EP-H);Norfluoxetine hydrochloride in methanol;Norfluoxetine Hydrochloride Solution, 100ppm;Fluoxetine Impurity 8(Fluoxetine EP Impurity H);Norfluoxetine hydrochloride (Desmethylfluoxetine);3-PHENYL-3-(4-TRIFLUOROMETHYL-PHENOXY)-PROPYLAMINE HYDROCHLORIDE;3-[4-(TRIFLUOROMETHYL)PHENOXY]-3-PHENYLPROPAN-1-AMINE HYDROCHLORIDE
CBNumber: CB1112230
Molecular Formula: C16H17ClF3NO
Formula Weight: 331.76
MOL File: 57226-68-3.mol

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NORFLUOXETINE HYDROCHLORIDE Property

storage temp.: -20°C
solubility: H₂O: >4 mg/mL
form: solid
color: yellow
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 15900
Product name: Norfluoxetine (hydrochloride)
Packaging: 1mg
Price: $45
Updated: 2024/03/01

Cayman Chemical

Product number: 15900
Product name: Norfluoxetine (hydrochloride)
Packaging: 10mg
Price: $277
Updated: 2024/03/01

Cayman Chemical

Product number: 15900
Product name: Norfluoxetine (hydrochloride)
Packaging: 5mg
Price: $198
Updated: 2024/03/01

TRC

Product number: N681100
Product name: Norfluoxetine hydrochloride
Packaging: 2mg
Price: $100
Updated: 2021/12/16

AK Scientific

Product number: 4422AJ
Product name: Norfluoxetine hydrochloride
Packaging: 5mg
Price: $98
Updated: 2021/12/16

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NORFLUOXETINE HYDROCHLORIDE Chemical Properties,Usage,Production

Description

Norfluoxetine is an active metabolite of the antidepressant fluoxetine. It is formed from fluoxetine by the cytochrome P450 (CYP) isoforms CYP2C9, CYP2C19, and CYP3A. Norfluoxetine inhibits serotonin (5-HT) uptake in rat brain synaptosomal membrane preparations (K_i = 44.7 nM) and isolated human platelets (IC₅₀ = ~15 nM). It has been found in the tissues of fish exposed to wastewater effluent.

Chemical Properties

NORFLUOXETINE HYDROCHLORIDE is Light Beige to Light Brown Solid

Uses

Norfluoxetine Hydrochloride is a metabolite of Fluoxetine (F597100), a selective serotonin reuptake inhibitor which is used as an antidepressant.

Uses

Norfluoxetine hydrochloride has been used to examine if psychoactive pharmaceuticals in drinking water at environmental concentrations could induce neuronal gene expression. It has also been used to examine whether at environmental concentrations it can alter in vitro expression of autism spectrum disorders (ASD)-associated synaptic proteins in human neurons.

Biochem/physiol Actions

Norfluoxetine is an active metabolite of fluoxetine. It disturbs the production of estrogen in a co-culture model of the feto-placental unit.

References

1) Veerman?et al.?(2013),?Slow delayed rectifier potassium current blockade contributes importantly to drug-induced long QT syndrome;?Circ. Arrythm. Electrophysiol.?6?1002 2) Lutz?et al.?(2013),?Stereoselective inhibition of CYP2C1 and CYP3A4 by fluoxetine and its metabolite: implications for risk assessment of multiple time-dependent inhibitor systems;?Drug Metab. Dispos.?41?2056 3) Wong?et al.?(1993),?Norfluoxetine enantiomers as inhibitors of serotonin uptake in rat brain;?Neuropsychopharmacology?8?337 4) Zuo?et al.?(2012),?Fluoxetine is a potent inhibitor of coxsackievirus replication.; Antimicrob. Agents Chemother.?56?4838 5) McClenaghan?et al.?(2016),?Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states; J. Gen. Physiol.?147?497

NORFLUOXETINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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57226-68-3, NORFLUOXETINE HYDROCHLORIDERelated Search:

Meta Fluoxetine Hydrochloride LXNAWNZZEQJKCC-UHFFFAOYSA-N N-Methyl-3-phenylpropan-1-aMine hydrochloride (RelCpd B) N-METHYL-3-CHLOROPROPYLAMINE HYDROCHLORIDE NORFLUOXETINE HYDROCHLORIDE FLUOXETINE HYDROCHLORIDE Bispyridoxine (3RS)-N-Methyl-3-phenyl-3-[2-(trifluoroMethyl)-phenoxy]propan-1-aMine Hydrochloride(2-TrifluoroMethylisoMer of Fluoxetine Hydro-chloride) 3-Dechloro-3-broMo Trazodone Hydrochloride Thioridazine-d3 Hydrochloride 4-Chlorobenzotrichloride Fluoxetine-D5 hydrochloride 3-dimethylamino-1-phenyl-propan-1-ol 3-(DIMETHYLAMINO)-1-PHENYLPROPAN-1-ONE 3-Chlorobenzotrifluoride 4-Trifluoromethylphenol 1-Phenyl-2-propen-1-one Fluoxetine Impurity 29

NORFLUOXETINE HCL

NORFLUOXETINE HYDROCHLORIDE

(+/-)-GAMMA-[4-(TRIFLUOROMETHYL)PHENOXY]-BENZENEPROPANAMINE HYDROCHLORIDE

3-PHENYL-3-(4-TRIFLUOROMETHYL-PHENOXY)-PROPYLAMINE HYDROCHLORIDE

3-[4-(TRIFLUOROMETHYL)PHENOXY]-3-PHENYLPROPAN-1-AMINE HYDROCHLORIDE

Benzenepropanamine, gamma-(4-(trifluoromethyl)phenoxy)-, hydrochloride

1-(3-Amino-1-phenylpropoxy)-4-(trifluoromethyl)benzene hydrochloride

Norfluoxetine Hydrochloride Solution, 100ppm

Fluoxetine Impurity 8(EP-H)

Fluoxetine EP Impurity H

Norfluoxetine hydrochloride (Desmethylfluoxetine)

Ca channels,P450,reuptake,Fluoxetine,Norfluoxetine Hydrochloride,CaV3.3,Inhibitor,anticonvulsant,inhibit,CYP2C19,5-HT,N-demethylated,serotonin,Serotonin Receptor,Ca2+ channels,CYP3A4,5-hydroxytryptamine Receptor,Drug Metabolite,Calcium Channel,metabolite,CYP2D6,5-HT Receptor,Norfluoxetine

Fluoxetine Impurity 8(Fluoxetine EP Impurity H)

Norfluoxetine hydrochloride in methanol

57226-68-3