VE 822

Product Name: VE 822
CAS No.: 1232416-25-9
Chemical Name: VE 822
Synonyms: Berzosertib;M6620;VX970 (VE-822);VX970;VE 822;M 6620;M-6620;CS-1487;M-66207;VE822; VE 822
CBNumber: CB42667115
Molecular Formula: C24H25N5O3S
Formula Weight: 463.55
MOL File: 1232416-25-9.mol

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VE 822 Property

Melting point:: >197°C (dec.)
Boiling point:: 674.4±55.0 °C(Predicted)
Density: 1.263±0.06 g/cm3(Predicted)
storage temp.: Refrigerator
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 8.88±0.10(Predicted)
form: Solid
color: Light Yellow
InChIKey: JZCWLJDSIRUGIN-UHFFFAOYSA-N
SMILES: C1(N)=NC=C(C2=CC=C(S(C(C)C)(=O)=O)C=C2)N=C1C1ON=C(C2=CC=C(CNC)C=C2)C=1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 24198
Product name: VE-822
Purity: ≥98%
Packaging: 5mg
Price: $30
Updated: 2021/12/16

Cayman Chemical

Product number: 24198
Product name: VE-822
Purity: ≥98%
Packaging: 10mg
Price: $57
Updated: 2021/12/16

Cayman Chemical

Product number: 24198
Product name: VE-822
Purity: ≥98%
Packaging: 25mg
Price: $113
Updated: 2021/12/16

Cayman Chemical

Product number: 24198
Product name: VE-822
Purity: ≥98%
Packaging: 50mg
Price: $210
Updated: 2021/12/16

Axon Medchem

Product number: Axon2452
Product name: VE822-Berzosertib|VX970
Purity: 99%
Packaging: 2x10mg
Price: $198
Updated: 2021/12/16

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VE 822 Chemical Properties,Usage,Production

Uses

3-[3-[4-[(Methylamino)methyl]phenyl]-5-isoxazolyl]-5-[4-[(1-methylethyl)sulfonyl]phenyl]-2-pyrazinamine is a novel ATR (ATM-Rad3-related) inhibitor for in vitro and in vivo radiosensatization.

Definition

ChEBI: 3-[3-[4-(methylaminomethyl)phenyl]-5-isoxazolyl]-5-(4-propan-2-ylsulfonylphenyl)-2-pyrazinamine is a sulfonamide.

in vivo

PSN-1 xenografts are treated with Berzosertib (VE-822) (60 mk/kg; d0, 1), NSC 613327 (100 mg/kg; d0) and/or XRT (6 Gy; d1). Tumors are then harvested 2 h post-XRT. Berzosertib (VE-822) inhibits p-Ser-345-Chk1 in xenografts after DNA-damaging agents, establishing VE-822 as a potent inhibitor of ATR in vivo. Besides, Berzosertib (VE-822) enhances the therapeutic efficacy of radiation (XRT) in MiaPaCa-2 and PSN-1 xenograft models^[1].

IC 50

ATR: 0.2 nM (Ki); ATM: 34 nM (Ki); PI3Kγ: 220 nM (Ki)

VE 822 Preparation Products And Raw materials

Raw materials

Preparation Products

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VE 822 Suppliers

China 134 India 2 United Kingdom 1 United States 12 Global 149

Chuzhou KeMail Chemical Technology Co., Ltd

Tel: 0550-5196001 15000891977
Fax: 0550-5196001
Email: wj520wjxby@126.com
Country: China
ProdList: 1944
Advantage: 55

Hubei Kele Fine Chemical Co., Ltd

Tel: 027-59101668 19945030958
Fax: 027-59101668
Email: 2881924765@qq.com
Country: China
ProdList: 7938
Advantage: 58

Changzhou Chenhong Biotechnology Co., Ltd.

Tel: +86-0519-85788828 +86-13775037613
Email: sales@chemrenpharm.com
Country: China
ProdList: 3934
Advantage: 58

Wuhan Topule

Tel: +86-02787215551 +86-19945035818
Fax: 027-87215551
Email: 2936752263@qq.com
Country: China
ProdList: 7986
Advantage: 58

Olix (Shanghai) Pharmaceutical Technology Co., Ltd

Tel: 17316404525 17316404525
Email: 209533805@qq.com
Country: China
ProdList: 9766
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

Tel: 17702719238 18971495150;
Email: sales@sun-shinechem.com
Country: China
ProdList: 1077
Advantage: 64

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4747
Advantage: 58

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1493
Advantage: 55

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

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View Lastest Price from VE 822 manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: VE 822 1232416-25-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-05-16

Career Henan Chemical Co

Product: VE 822 1232416-25-9
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-23

1232416-25-9, VE 822Related Search:

VX-745 (S)-1-((S)-2-(4-amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)-N-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-yl)pyrrolidine-2-carboxamide AVN-944 Telaprevir VX-770 Pimodivir NU7441 (KU-57788) Bortezomib Y27632 (hydrochloride) VE-821 KU-60019 Olaparib

VX970 (VE-822)

2-Pyrazinamine, 3-[3-[4-[(methylamino)methyl]phenyl]-5-isoxazolyl]-5-[4-[(1-methylethyl)sulfonyl]phenyl]-

VX970

3-[3-[4-[(Methylamino)methyl]phenyl]-5-isoxazolyl]-5-[4-[(1-methylethyl)sulfonyl]phenyl]-2-pyrazinamine VE-822

VE 822 3-[3-[4-[(Methylamino)methyl]phenyl]-5-isoxazolyl]-5-[4-[(1-methylethyl)sulfonyl]phenyl]-2-pyrazinamine

VE 822

3-[3-[4-[(Methylamino)methyl]phenyl]-5-isoxazolyl]-5-[4-[(1-methylethyl)sulfonyl]phenyl]-2-pyrazinamine

VE822; VE 822

CS-1487

VE-822 (VX-970)

Berzosertib (Synonyms: VE-822

M 6620

M6620

M-6620

M6620; M-6620; M 6620; VE822; VE-822; VE 822; VX970; VX-970; VX 970;

3-[3-[4-(methylaminomethyl)phenyl]-1,2-oxazol-5-yl]-5-(4-propan-2-ylsulfonylphenyl)pyrazin-2-amine

VE-822 (Berzosertib)

Berzosertib

Berzosertib(VE-822)

3-(3-{4-[(methylamino)methyl]phenyl}-1,2-oxazol-5-yl)-5-[4-(propane-2-sulfonyl)phenyl]pyrazin-2-amine

VE 822 USP/EP/BP

5-(4-(Isopropylsulfonyl)phenyl)-3-(3-(4-((methylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine

VE822 ATR inhibitor VE-822

2-Amino-5-[4-(isopropylsulfonyl)phenyl]-3-[3-[4-[(methylamino)methyl]phenyl]-5-isoxazolyl]pyrazine

Berzosertib, 10 mM in DMSO

3-[3-[4-[(Methylamino)methyl]phenyl]-5-isoxazolyl]-5-[4-[(1-methylethyl)sulfonyl]phenyl]-2-pyrazinam

M-66207

1232416-25-9

C24H25N5O3S

Inhibitors