Y-27632 dihydrochloride

Product Name: Y-27632 dihydrochloride
CAS No.: 129830-38-2
Chemical Name: Y-27632 dihydrochloride
Synonyms: CS-1919;Y27632 HCl;Y-27633 (2 HCl);27632 (hydrochloride);Y27632 (hydrochloride);Y-27632 DIHYDROCHLORIDE;Y-27632; Y27632; Y 27632;Y-27632, Sterile-Filtered;Y-27632 dihydrochloride, >=98%;Y-27632 dihydrochloride Y27632
CBNumber: CB82526054
Molecular Formula: C14H23Cl2N3O
Formula Weight: 320.25792
MOL File: 129830-38-2.mol

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Y-27632 dihydrochloride Property

Melting point:: 258℃
storage temp.: 2-8°C
solubility: H2O: soluble14mg/mL
form: powder
color: white to beige
biological source: synthetic (organic)
optical activity: [α]/D +3.0 to +5.0°, c =1.0 in methanol
Water Solubility: H2O: 14mg/mL
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or methanol may be stored at -20° for up to 3 months.
InChI: InChI=1/C14H21N3O.2ClH/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13;;/h6-12H,2-5,15H2,1H3,(H,16,17,18);2*1H/t10-,11,12;;/s3
InChIKey: IDDDVXIUIXWAGJ-MEIAXHMCNA-N
SMILES: C1(C(NC2=CC=NC=C2)=O)CCC([C@H](N)C)CC1.[H]Cl.[H]Cl |&1:13,r|

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22
Safety Statements: 36
WGK Germany: 3
HS Code: 29333990
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0503
Product name: Y-27632 dihydrochloride
Purity: ≥98% (HPLC)
Packaging: 1mg
Price: $257
Updated: 2026/03/19

Sigma-Aldrich

Product number: Y0503
Product name: Y-27632 dihydrochloride
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $876
Updated: 2026/03/19

TCI Chemical

Product number: Y0018
Product name: Y 27632 Dihydrochloride
Packaging: 10MG
Price: $176
Updated: 2022/04/27

TCI Chemical

Product number: Y0018
Product name: Y 27632 Dihydrochloride
Packaging: 50MG
Price: $527
Updated: 2022/04/27

Cayman Chemical

Product number: 10005583
Product name: Y-27632 (hydrochloride)
Purity: ≥98%
Packaging: 1mg
Price: $57
Updated: 2024/03/01

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Y-27632 dihydrochloride Chemical Properties,Usage,Production

Description

Y-27632 dihydrochloride (129830-38-2) is a specific inhibitor of ROCK family kinases.1 Enhances stem cell survival and proliferation in culture.2 Y-27632 dihydrochloride significantly improves freeze/thaw survival rate for human embryonic stem cells without influencing morphology, karyotype, cell surface markers, or differentiation potential.3

Uses

A cell permeable inhibitor of ROCK-1 and ROCK-2

Uses

Y-27632 dihydrochloride has been used:

as a medium supplement in pancreatic ductal adenocarcinoma organoid culture
in the inhibition of Ras homolog gene family (Rho) kinase in mouse embryonic stem cells
in the inhibition of Rho-associated protein kinase (ROCK) in human embryonic stem cells and human induced pluripotent stem cells (iPSCs)

General Description

Y-27632 dihydrochloride is an effective bronchodilator and improves lung resistance (RL) induced by antigen and acetylcholine. Y-27632 controls neutrophil migration and lung edema and may be a potential drug for treating acute lung injury.

Biochem/physiol Actions

Y-27632 is highly potent, cell-permeable, selective ROCK (Rho-associated coiled coil forming protein serine/threonine kinase) inhibitor. Ki = 140 nM for p160ROCK. Y-27632 also inhibits ROCK-II with equal potency. The inhibition is competitive with respect to ATP.

storage

Desiccate at RT

References

[1] T ISHIZAKI. Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases.[J]. Molecular Pharmacology, 2000, 57 5: 976-983.
[2] KALAMEGAM GAUTHAMAN Ariff B Chui Yee Fong. Effect of ROCK inhibitor Y-27632 on normal and variant human embryonic stem cells (hESCs) in vitro: its benefits in hESC expansion.[J]. Stem Cell Reviews and Reports, 2010, 6 1: 86-95. DOI:10.1007/s12015-009-9107-8
[3] XIANGYUN LI. The ROCK inhibitor Y-27632 enhances the survival rate of human embryonic stem cells following cryopreservation.[J]. Stem cells and development, 2008, 17 6: 1079-1085. DOI:10.1089/scd.2007.0247
[4] JEAN-DAVID MOREL. Proteomics Reveals Scope of Mycolactone-mediated Sec61 Blockade and Distinctive Stress Signature.[J]. Molecular & cellular proteomics : MCP, 2018: 1750-1765. DOI:10.1074/mcp.ra118.000824
[5] M. YAMAZAKI H M H Fujie. Chromatin condensation retains the osteogenic transcription factor, RUNX2, in the nucleus of human mesenchymal stem cells[J]. Journal of Biomechanical Science and Engineering, 1900, 1 1. DOI:10.1299/jbse.20-00083

Y-27632 dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Y-27632 dihydrochloride Suppliers

Canada 1 China 195 India 1 Japan 1 United Kingdom 2 United States 23 Global 223

Shanghai Tube Pharmaceutical Co., Ltd.

Tel: 021-54338626 18017892860
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TargetMol Chemicals Inc.

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Suzhou MgPlus Pharmtech Co., Ltd.

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ShangHai Biochempartner Co.,Ltd

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Dezhou LonWel Pharmaceutical Technology Co., Ltd.

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Shanghai Hanhong Scientific Co.,Ltd.

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Chemsky (shanghai) International Co.,Ltd

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Jinan Trio PharmaTech Co., Ltd.

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View Lastest Price from Y-27632 dihydrochloride manufacturers

Career Henan Chemica Co

Product: Y27632 (hydrochloride) 129830-38-2
Price: US $3.07/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1000KG
Release date: 2020-10-27

R&D Scientific Inc.

Product: Y-27632 dihydrochloride 129830-38-2
Price: US $1400.00/g
Min. Order: 1g
Purity: 98
Supply Ability: 50 Kg
Release date: 2024-02-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: Cabergoline 81409-90-7
Price: US $3090.00/g/Bag
Min. Order: 1g/Bag
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 100KG
Release date: 2021-07-02

129830-38-2, Y-27632 dihydrochlorideRelated Search:

Y-27632 YC-1 YKP-3089 BenzaMide, N-[4-chloro-3-(trifluoroMethyl)phenyl]-2-[2-(diMethylaMino)ethoxy]-6-ethoxy- N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE Y320 (R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide 3-(4-Pyridyl)indole Fasudil hydrochloride SB 431542 MG-132 CHIR-99021 YH239-EE YKL 06-061 YS 49 (R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride PD 0325901 trans-4-MethoxycyclohexanaMine

Y-27632; Y27632; Y 27632

CS-1919

Y-27632; Y27632; Y 27632;Y 27632 DIHYDROCHLORIDE;Y27632 DIHYDROCHLORIDE

Y-27632 dihydrochloride, 98.5%, a selective ROCK1 (p160ROCK) inhibitor

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Y-27632 dihydrochloride, >=98%

trans-4-[(R)-1-Aminoethyl]-N-(4-pyridyl)cyclohexanecarboxamide dihydrochloride Y 27632 dihydrochloride

Y 27632 dihydrochloride (+)-trans-N-(4-Pyridyl)-4-[(R)-1-aminoethyl]cyclohexanecarboxamide dihydrochloride

Y27632 (hydrochloride)

(+)-trans-N-(4-Pyridyl)-4-[(R)-1-aminoethyl]cyclohexanecarboxamide dihydrochloride

trans-4-[(R)-1-Aminoethyl]-N-(4-pyridyl)cyclohexanecarboxamide dihydrochloride

Y27632 HCl

Y-27632, Dihydrochloride Salt, >99%

trans-4-((R)-1-Aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide dihydrochloride

Y27632 (hydrochloride) USP/EP/BP

Trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride (Y-27632 dihydrochloride)

Cyclohexanecarboxamide, 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-, hydrochloride (1:2), trans-

Y-27632 dihydrochloride Y27632

27632 (hydrochloride)

Y-27632 dihydrochloride (mM/ml), Rho kinase inhibitor

Y-27632, Sterile-Filtered

Y-27632 dihydrochloride, Rho kinase inhibitor

Y-27632 in solution New

Y-27632 dihydrochloride, 10 mM in DMSO

Abmole M1817-100mg Y-27632 dihydrochloride 129830-38-2

Y-27632 DIHYDROCHLORIDE

Y-27633 (2 HCl)

129830-38-2

Csub1subsub4subHsub2subsub1subNsub3subO2HCl

Inhibitors

APIs