Y27632 (hydrochloride)
- Product Name
- Y27632 (hydrochloride)
- CAS No.
- 129830-38-2
- Chemical Name
- Y27632 (hydrochloride)
- Synonyms
- CS-1919;Y27632 HCl;27632 (hydrochloride);Y27632 (hydrochloride);Y-27632; Y27632; Y 27632;Y-27632 dihydrochloride, >=98%;Y-27632 dihydrochloride Y27632;Y27632 (hydrochloride) USP/EP/BP;Y-27632, Dihydrochloride Salt, >99%;Y-27632 DIHYDROCHLORIDE;ROCK INHIBITOR
- CBNumber
- CB82526054
- Molecular Formula
- C14H23Cl2N3O
- Formula Weight
- 320.25792
- MOL File
- 129830-38-2.mol
Y27632 (hydrochloride) Property
- Melting point:
- 258℃
- storage temp.
- 2-8°C
- solubility
- H2O: soluble14mg/mL
- form
- powder
- color
- white to beige
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or methanol may be stored at -20° for up to 3 months.
N-Bromosuccinimide Price
- Product number
- Y0503
- Product name
- Y-27632 dihydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 1mg
- Price
- $232
- Updated
- 2024/03/01
- Product number
- Y0503
- Product name
- Y-27632 dihydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $795
- Updated
- 2024/03/01
- Product number
- Y0018
- Product name
- Y 27632 Dihydrochloride
- Packaging
- 10MG
- Price
- $176
- Updated
- 2022/04/27
- Product number
- Y0018
- Product name
- Y 27632 Dihydrochloride
- Packaging
- 50MG
- Price
- $527
- Updated
- 2022/04/27
- Product number
- 10005583
- Product name
- Y-27632 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $57
- Updated
- 2024/03/01
Y27632 (hydrochloride) Chemical Properties,Usage,Production
Description
Y-27632 dihydrochloride (129830-38-2) is a specific inhibitor of ROCK family kinases.1 Enhances stem cell survival and proliferation in culture.2 Y-27632 dihydrochloride significantly improves freeze/thaw survival rate for human embryonic stem cells without influencing morphology, karyotype, cell surface markers, or differentiation potential.3
Uses
A cell permeable inhibitor of ROCK-1 and ROCK-2
Uses
Y-27632 dihydrochloride has been used:
- as a medium supplement in pancreatic ductal adenocarcinoma organoid culture
- in the inhibition of Ras homolog gene family (Rho) kinase in mouse embryonic stem cells
- in the inhibition of Rho-associated protein kinase (ROCK) in human embryonic stem cells and human induced pluripotent stem cells (iPSCs)
General Description
Y-27632 dihydrochloride is an effective bronchodilator and improves lung resistance (RL) induced by antigen and acetylcholine. Y-27632 controls neutrophil migration and lung edema and may be a potential drug for treating acute lung injury.
Biochem/physiol Actions
Y-27632 is highly potent, cell-permeable, selective ROCK (Rho-associated coiled coil forming protein serine/threonine kinase) inhibitor. Ki = 140 nM for p160ROCK. Y-27632 also inhibits ROCK-II with equal potency. The inhibition is competitive with respect to ATP.
storage
Desiccate at RT
References
1) Ishizaki et al. (2000), Pharmacological Properties of Y-27632, a Specific Inhibitor of Rho-Associated Kinases; Mol. Pharmacol., 57 976 2) Gauthaman et al. (2010), Effects of ROCK Inhibitor Y-27632 on Normal and Variant Human Embryonic Stem Cells (hESCs) In Vitro: Its Benefits in hESC Expansion; Stem Cell Rev., 6 86 3) Li et al. (2008), The ROCK Inhibitor Y-27632 enhances the Survival Rate of Human Embryonic Stem Cells Following Cryopreservation; Stem Cells Dev., 17 1079 4) Morel et al. (2018), Proteomics Reveals Scope of Mycolactone-mediated Sec61 Blockade and Distinctive Stress Signature Y-27632; Mol. Cell. Proteomics, 17 1750 [Focus Citation] 5) Yamazaki et al. (2020) Chromatin condensation retains the osteogenic transcription factor, RUNX2, in the nucleus of human mesenchymal stem cells; J. Biomechanical Science and Engineering 15? 1 [Focus Citation]
Y27632 (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
Y27632 (hydrochloride) Suppliers
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View Lastest Price from Y27632 (hydrochloride) manufacturers
- Product
- Y-27632 dihydrochloride 129830-38-2
- Price
- US $1400.00/g
- Min. Order
- 1g
- Purity
- 98
- Supply Ability
- 50 Kg
- Release date
- 2024-02-11
- Product
- Cabergoline 81409-90-7
- Price
- US $3090.00/g/Bag
- Min. Order
- 1g/Bag
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 100KG
- Release date
- 2021-07-02
- Product
- Y27632 (hydrochloride) 129830-38-2
- Price
- US $3.07/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1000KG
- Release date
- 2020-10-27