3-(4-Pyridyl)indole

Product Name: 3-(4-Pyridyl)indole
CAS No.: 7272-84-6
Chemical Name: 3-(4-Pyridyl)indole
Synonyms: 3-(4-Pyridyl);3-(4-Pyridinyl)-;ROCK Inhibitor III;3-(4-Pyridyl)indole;Rho Kinase Inhibitor III;3-(4-Pyridinyl)-1H-indole;1H-Indole, 3-(4-pyridinyl)-;Rho Kinase Inhibitor III, Rockout;RHO KINASE INHIBITOR III; ROCK INHIBITOR III; ROCKOUT;Rho Kinase Inhibitor III, Rockout - CAS 7272-84-6 - Calbiochem
CBNumber: CB01564970
Molecular Formula: C13H10N2
Formula Weight: 194.23
MOL File: 7272-84-6.mol

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3-(4-Pyridyl)indole Property

storage temp.: +2C to +8C
solubility: DMSO, Methanol
form: Yellow solid
color: Yellow
Stability:: Light Sensitive
CAS DataBase Reference: 7272-84-6

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 555553
Product name: Rho Kinase Inhibitor III, Rockout - CAS 7272-84-6 - Calbiochem
Packaging: 10mg
Price: $159
Updated: 2024/03/01

Cayman Chemical

Product number: 17922
Product name: 3-(4-Pyridyl)indole
Purity: ≥98%
Packaging: 5mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 17922
Product name: 3-(4-Pyridyl)indole
Purity: ≥98%
Packaging: 10mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 17922
Product name: 3-(4-Pyridyl)indole
Purity: ≥98%
Packaging: 25mg
Price: $161
Updated: 2024/03/01

Cayman Chemical

Product number: 17922
Product name: 3-(4-Pyridyl)indole
Purity: ≥98%
Packaging: 50mg
Price: $283
Updated: 2024/03/01

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3-(4-Pyridyl)indole Chemical Properties,Usage,Production

Description

Two Rho-associated kinases (ROCK), ROCK1 and ROCK2, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. 3-(4-Pyridyl)indole is a ROCK1 inhibitor (IC₅₀ = 25 μM) that promotes cell spreading, inhibits membrane blebbing, and induces dissolution of actin stress fibers in a wound healing assay. It also inhibits ROCK2 and PRK2, another Rho-dependent kinase, with similar potency, while inhibiting MSK-1 and PKA with relatively weaker potency.

Chemical Properties

Yellow Solid

Uses

Two Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. 3-(4-Pyridyl)indole is a ROCK-I inhibitor (IC50 = 25 μM) that promotes cell spreading, inhibits membrane blebbing, and induces dissolution of actin stress fibers in a wound healing assay. It also inhibits ROCK-II and PRK2, another Rho-dependent kinase, with similar potency, while inhibiting MSK-1 and PKA with relatively weaker potency.[Cayman Chemical]

Uses

A cell-permeable indolopyridine compound that acts as a selective, ATP-competitive inhibitor of Rho kinase (ROCK) activity.

Definition

ChEBI: 3-pyridin-4-yl-1H-indole is a member of indoles.

General Description

A cell-permeable indolopyridine compound that acts as a selective, reversible, and ATP-competitive inhibitor of Rho kinase activity with an IC₅₀ of 25 μM. Does not inhibit the activation of Rho kinase nor does it affect the in vitro activities of MLCK, PKCα, and SAPK2a/p38α. Shown to be 5-fold less potent than Y-27632 (Cat. No. 688000; IC₅₀ = ~5 μM), and display a similar specificity profile as H-89 (Cat. No. 371963). Affects cell migration, inhibits blebbing (IC₅₀ = ~ 12 μM in M2 cells), and decreases stress fibers in Bulb 3T3 cells at 50 μM.

Biochem/physiol Actions

Cell permeable: yes

References

[1] yarrow j c, totsukawa g, charras g t, et al. screening for cell migration inhibitors via automated microscopy reveals a rho-kinase inhibitor[j]. chemistry & biology, 2005, 12(3): 385-395.
[2] amano m, fukata y, kaibuchi k. regulation and functions of rho-associated kinase[j]. experimental cell research, 2000, 261(1): 44-51.

3-(4-Pyridyl)indole Preparation Products And Raw materials

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Preparation Products

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View Lastest Price from 3-(4-Pyridyl)indole manufacturers

Career Henan Chemica Co

Product: 3-(4-Pyridyl)indole 7272-84-6
Price: US $0.37/g
Min. Order: 1g
Purity: 99%
Supply Ability: 10kg,100kg Cherry 0956
Release date: 2020-11-29

7272-84-6, 3-(4-Pyridyl)indoleRelated Search:

Y27632 (hydrochloride)

Rho Kinase Inhibitor III, Rockout - CAS 7272-84-6 - Calbiochem

Rho Kinase Inhibitor III

RHO KINASE INHIBITOR III; ROCK INHIBITOR III; ROCKOUT

ROCK Inhibitor III

3-(4-Pyridyl)

3-(4-Pyridinyl)-

Rho Kinase Inhibitor III, Rockout

1H-Indole, 3-(4-pyridinyl)-

3-(4-Pyridinyl)-1H-indole

3-(4-Pyridyl)indole

7272-84-6

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