Y27632 (hydrochloride)

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Y27632 (hydrochloride)

Product Name: Y27632 (hydrochloride)
CAS No.: 129830-38-2
Chemical Name: Y27632 (hydrochloride)
Synonyms: CS-1919;Y27632 HCl;27632 (hydrochloride);Y27632 (hydrochloride);Y-27632; Y27632; Y 27632;Y-27632 dihydrochloride, >=98%;Y-27632 dihydrochloride Y27632;Y27632 (hydrochloride) USP/EP/BP;Y-27632, Dihydrochloride Salt, >99%;Y-27632 DIHYDROCHLORIDE;ROCK INHIBITOR
CBNumber: CB82526054
Molecular Formula: C14H23Cl2N3O
Formula Weight: 320.25792
MOL File: 129830-38-2.mol

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Y27632 (hydrochloride) Property

Melting point:: 258℃
storage temp.: 2-8°C
solubility: H2O: soluble14mg/mL
form: powder
color: white to beige
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or methanol may be stored at -20° for up to 3 months.

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22
Safety Statements: 36
WGK Germany: 3
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0503
Product name: Y-27632 dihydrochloride
Purity: ≥98% (HPLC)
Packaging: 1mg
Price: $232
Updated: 2024/03/01

Sigma-Aldrich

Product number: Y0503
Product name: Y-27632 dihydrochloride
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $795
Updated: 2024/03/01

TCI Chemical

Product number: Y0018
Product name: Y 27632 Dihydrochloride
Packaging: 10MG
Price: $176
Updated: 2022/04/27

TCI Chemical

Product number: Y0018
Product name: Y 27632 Dihydrochloride
Packaging: 50MG
Price: $527
Updated: 2022/04/27

Cayman Chemical

Product number: 10005583
Product name: Y-27632 (hydrochloride)
Purity: ≥98%
Packaging: 1mg
Price: $57
Updated: 2024/03/01

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Y27632 (hydrochloride) Chemical Properties,Usage,Production

Description

Y-27632 dihydrochloride (129830-38-2) is a specific inhibitor of ROCK family kinases.1 Enhances stem cell survival and proliferation in culture.2 Y-27632 dihydrochloride significantly improves freeze/thaw survival rate for human embryonic stem cells without influencing morphology, karyotype, cell surface markers, or differentiation potential.3

Uses

A cell permeable inhibitor of ROCK-1 and ROCK-2

Uses

Y-27632 dihydrochloride has been used:

as a medium supplement in pancreatic ductal adenocarcinoma organoid culture
in the inhibition of Ras homolog gene family (Rho) kinase in mouse embryonic stem cells
in the inhibition of Rho-associated protein kinase (ROCK) in human embryonic stem cells and human induced pluripotent stem cells (iPSCs)

General Description

Y-27632 dihydrochloride is an effective bronchodilator and improves lung resistance (RL) induced by antigen and acetylcholine. Y-27632 controls neutrophil migration and lung edema and may be a potential drug for treating acute lung injury.

Biochem/physiol Actions

Y-27632 is highly potent, cell-permeable, selective ROCK (Rho-associated coiled coil forming protein serine/threonine kinase) inhibitor. Ki = 140 nM for p160ROCK. Y-27632 also inhibits ROCK-II with equal potency. The inhibition is competitive with respect to ATP.

storage

Desiccate at RT

References

1) Ishizaki et al. (2000), Pharmacological Properties of Y-27632, a Specific Inhibitor of Rho-Associated Kinases; Mol. Pharmacol., 57 976 2) Gauthaman et al. (2010), Effects of ROCK Inhibitor Y-27632 on Normal and Variant Human Embryonic Stem Cells (hESCs) In Vitro: Its Benefits in hESC Expansion; Stem Cell Rev., 6 86 3) Li et al. (2008), The ROCK Inhibitor Y-27632 enhances the Survival Rate of Human Embryonic Stem Cells Following Cryopreservation; Stem Cells Dev., 17 1079 4) Morel et al. (2018), Proteomics Reveals Scope of Mycolactone-mediated Sec61 Blockade and Distinctive Stress Signature Y-27632; Mol. Cell. Proteomics, 17 1750 [Focus Citation] 5) Yamazaki et al. (2020) Chromatin condensation retains the osteogenic transcription factor, RUNX2, in the nucleus of human mesenchymal stem cells; J. Biomechanical Science and Engineering 15? 1 [Focus Citation]

Y27632 (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Y27632 (hydrochloride) manufacturers

Career Henan Chemica Co

Product: Y27632 (hydrochloride) 129830-38-2
Price: US $3.07/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1000KG
Release date: 2020-10-27

R&D Scientific Inc.

Product: Y-27632 dihydrochloride 129830-38-2
Price: US $1400.00/g
Min. Order: 1g
Purity: 98
Supply Ability: 50 Kg
Release date: 2024-02-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: Cabergoline 81409-90-7
Price: US $3090.00/g/Bag
Min. Order: 1g/Bag
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 100KG
Release date: 2021-07-02

129830-38-2, Y27632 (hydrochloride)Related Search:

Y-27632 DIHYDROCHLORIDE YC-1 YKP-3089 BenzaMide, N-[4-chloro-3-(trifluoroMethyl)phenyl]-2-[2-(diMethylaMino)ethoxy]-6-ethoxy- N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE Y320 (R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide (R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride YH239-EE YKL 06-061 YS 49 3-(4-Pyridyl)indole Fasudil hydrochloride SB 431542 PD 0325901 MG-132 CHIR-99021 trans-4-Phenyl-L-proline hydrochloride

Y-27632; Y27632; Y 27632

CS-1919

Y-27632; Y27632; Y 27632;Y 27632 DIHYDROCHLORIDE;Y27632 DIHYDROCHLORIDE

Y-27632 dihydrochloride, 98.5%, a selective ROCK1 (p160ROCK) inhibitor

(R)-4-(1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide dihydrochloride

Y-27632 DIHYDROCHLORIDE;ROCK INHIBITOR

Y-27632 dihydrochloride, >=98%

trans-4-[(R)-1-Aminoethyl]-N-(4-pyridyl)cyclohexanecarboxamide dihydrochloride Y 27632 dihydrochloride

Y 27632 dihydrochloride (+)-trans-N-(4-Pyridyl)-4-[(R)-1-aminoethyl]cyclohexanecarboxamide dihydrochloride

Y27632 (hydrochloride)

(+)-trans-N-(4-Pyridyl)-4-[(R)-1-aminoethyl]cyclohexanecarboxamide dihydrochloride

trans-4-[(R)-1-Aminoethyl]-N-(4-pyridyl)cyclohexanecarboxamide dihydrochloride

Y27632 HCl

Y-27632, Dihydrochloride Salt, >99%

trans-4-((R)-1-Aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide dihydrochloride

Y27632 (hydrochloride) USP/EP/BP

Trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride (Y-27632 dihydrochloride)

Cyclohexanecarboxamide, 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-, hydrochloride (1:2), trans-

Y-27632 dihydrochloride Y27632

27632 (hydrochloride)

129830-38-2

Inhibitors

APIs