ChemicalBook > CAS DataBase List > MG-132

MG-132

Product Name
MG-132
CAS No.
133407-82-6
Chemical Name
MG-132
Synonyms
MG-132;CS-216;Z-LL-CHO;Z-LLL-al;Z-LLL-CHO;(S)-MG132;MG132/MG-132;MG-132, >=98%;Z-LEU-LEU-LEU-H;z-leu-leu-leu-al
CBNumber
CB3298042
Molecular Formula
C26H41N3O5
Formula Weight
475.62
MOL File
133407-82-6.mol
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MG-132 Property

Melting point:
80-84℃ (DEC.)
alpha 
-61~-67°
Boiling point:
682.0±55.0 °C(Predicted)
Density 
1.073
Flash point:
366℃
storage temp. 
−20°C
solubility 
methanol: 1 mg/mL
pka
11.14±0.46(Predicted)
form 
solid film
color 
White
Water Solubility 
Soluble in ethanol, chloroform, methanol, water.
InChIKey
TZYWCYJVHRLUCT-VABKMULXSA-N
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Safety

Risk Statements 
36/37/38
Safety Statements 
24/25
WGK Germany 
3
HS Code 
29242990
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
474790
Product name
MG-132
Purity
A cell-permeable, potent, reversible proteasome inhibitor (K
Packaging
1mg
Price
$42.36
Updated
2021/03/22
Sigma-Aldrich
Product number
474787
Product name
MG-132, ≥95% by HPLC
Packaging
10mg
Price
$69.4
Updated
2021/03/22
Alfa Aesar
Product number
J63250
Product name
MG 132
Packaging
5mg
Price
$108
Updated
2021/03/22
Alfa Aesar
Product number
J63250
Product name
MG 132
Packaging
1mg
Price
$27.5
Updated
2021/03/22
Cayman Chemical
Product number
10012628
Product name
(S)-MG132
Purity
≥98%
Packaging
1mg
Price
$15
Updated
2021/03/22
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MG-132 Chemical Properties,Usage,Production

Uses

A proteasome and NF-κB inhibitor.

Definition

ChEBI: A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is protected as its benzyloxycarbonyl derivative.

Biological Activity

Potent cell-permeable inhibitor of proteasome (IC 50 = 100 nM) and calpain (IC 50 = 1.2 μ M). Inhibits TNF- α -induced NF- κ B activation and I κ B α degradation. Induces neurite outgrowth in PC12 cells and has anticancer properties in vitro .

MG-132 Preparation Products And Raw materials

Raw materials

Preparation Products

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MG-132 Suppliers

Guangzhou Zhiya Chemdrugs Co.,Ltd
Tel
Fax
QQ:2869377561
Email
sculk28@163.com
Country
China
ProdList
805
Advantage
55
Shanghai BRILLIA Pharmaceutical Co., Ltd
Tel
021-60448595
Email
derek1229@163.com;derek1229@163.com
Country
China
ProdList
55
Advantage
58
Shanghai TaoShu Biochemical Technology Co., Ltd.
Tel
021-33632979-
Fax
021-33632979
Email
service1@targetmol.com
Country
China
ProdList
7962
Advantage
58
Creative Peptides
Email
info@creative-peptides.com
Country
United States
ProdList
6070
Advantage
56
Cangzhou Pintuo Biotechnology Co., Ltd.
Tel
Email
1979763395@qq.com
Country
China
ProdList
187
Advantage
58
Hangzhou Guangyuan Biotechnologies Co.,LTD
Email
services@raystarbio.com
Country
China
ProdList
3991
Advantage
58
Hangzhou Peptidego Biotech Co.,Ltd.
Tel
0571-87213919-
Fax
0571-87213919
Email
eric@peptidego.com
Country
China
ProdList
4561
Advantage
58
Nantong Hi-Future Biotechnology Co., Ltd
Tel
Email
1185838023@qq.com
Country
China
ProdList
464
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2926
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
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View Lastest Price from MG-132 manufacturers

Wuhan wingroup Pharmaceutical Co., Ltd
Product
MG-132 133407-82-6
Price
US $5.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 Tons
Release date
2021-07-08
Career Henan Chemical Co
Product
MG-132 133407-82-6
Price
US $1.00/g
Min. Order
1g
Purity
99.99%
Supply Ability
2tons
Release date
2019-12-19

133407-82-6, MG-132Related Search:


  • PROTEASOME INHIBITOR MG-132
  • N-[(PHENYLMETHOXY)CARBONYL]-L-LEUCYL-N-[(1S)-1-FORMYL-3-METHYLBUTYL]-L-LEUCINAMIDE
  • N-CBZ-LEU-LEU-LEUCINAL
  • MG-132
  • Z-LLL-CHO
  • Z-LL-CHO
  • Z-LEU-LEU-LEU-CHO
  • Z-LEU-LEU-LEU-H
  • Z-LEU-LEU-LEU-H (ALDEHYDE)
  • Z-LEU-LEU-LEU-ALDEHYDE
  • Z-LEU-LEU-ALDEHYDE
  • N-cbz-leu-leu-leu-al
  • z-leu-leu-leu-al
  • CALPAIN INHIBITOR IV
  • CARBOBENZOXY-L-LEUCYL-L-LEUCYL-LEUCINAL
  • CARBOBENZOXY-L-LEUCYL-L-LEUCYL-L-LEUCINAL
  • BENZYLOXYCARBONYL-L-LEUCYL-L-LEUCYL-L-LEUCINAL
  • benzyloxycarbonylleucyl-leucyl-leucinealdehyde
  • (S)-MG132
  • N-carbobenzyloxy-Leu-Leu-Leu-al
  • MG-132;Z-LEU-LEU-LEU-AL
  • Z-Leu-Leu-Leu-al,MG132
  • Calpain inhibitor IV-2
  • MG 132;MG132;Z-LEU-LEU-LEU-CHO;CARBOBENZOXY-L-LEUCYL-L-LEUCYL-L-LEUCINAL
  • L-LeucinaMide, N-[(phenylMethoxy)carbonyl]-L-leucyl-N-[(1S)-1-forMyl-3-Methylbutyl]-
  • MG132/MG-132
  • MG-132 [Z-Leu-Leu-Leu-CHO]
  • Z-LEU-LEU-LEU-AL, >=90% (HPLC)
  • Benzyl (S)-4-methyl-1-((S)-4-methyl-1-((S)-4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylami
  • InSolution? MG-132
  • MG-132, ≥95% by HPLC
  • N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal
  • MG132, 98%, proteasome inhibitor
  • benzyl ((S)-4-Methyl-1-(((S)-4-Methyl-1-(((S)-4-Methyl-1-oxopentan-2-yl)aMino)-1-oxopentan-2-yl)aMino)-1-oxopentan-2-yl)carbaMate
  • MG 132 Calpain inhibitor IV-2
  • N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide Calpain inhibitor IV-2 MG 132
  • MG-132, >=98%
  • CS-216
  • MG-132 - CAS 133407-82-6 - Calbiochem
  • MG-132, ≥95% by HPLC - CAS 133407-82-6 - Calbiochem
  • InSolution MG-132 - CAS 133407-82-6 - Calbiochem
  • benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate
  • Z-LLL-al
  • 133407-82-6
  • C26H41N3O5
  • Cell Signaling Enzymes
  • BioChemical
  • Biochemicals and Reagents
  • Application Index
  • Enzymes, Inhibitors, and Substrates
  • Proteasome, Calpain and Lysosomal Proteases
  • Proteasomes
  • Inhibitors
  • API
  • peptides
  • inhibitor
  • Aldehydes
  • and Substrates