MG-132
- Product Name
- MG-132
- CAS No.
- 133407-82-6
- Chemical Name
- MG-132
- Synonyms
- MG-132;CS-216;Z-LL-CHO;Z-LLL-al;Z-LLL-CHO;(S)-MG132;MG-132(SSS);MG132/MG-132;MG-132, >=98%;Z-LEU-LEU-LEU-H
- CBNumber
- CB3298042
- Molecular Formula
- C26H41N3O5
- Formula Weight
- 475.62
- MOL File
- 133407-82-6.mol
MG-132 Property
- Melting point:
- 80-84℃ (DEC.)
- alpha
- -61～-67°
- Boiling point:
- 682.0±55.0 °C(Predicted)
- Density
- 1.073
- Flash point:
- 366℃
- storage temp.
- -20°C
- solubility
- methanol: 1 mg/mL
- form
- solid film
- pka
- 11.14±0.46(Predicted)
- color
- White
- Water Solubility
- Soluble in ethanol, chloroform, methanol, water.
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO, DMF or ethanol may be stored at -20° for up to 1 week.
- InChIKey
- TZYWCYJVHRLUCT-VABKMULXSA-N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- 474790
- Product name
- MG-132
- Purity
- A cell-permeable, potent, reversible proteasome inhibitor (K
- Packaging
- 1mg
- Price
- $56.2
- Updated
- 2024/03/01
- Product number
- 474787
- Product name
- MG-132, ≥95% by HPLC
- Packaging
- 10mg
- Price
- $85.2
- Updated
- 2024/03/01
- Product number
- J63250
- Product name
- MG 132
- Packaging
- 1mg
- Price
- $35.4
- Updated
- 2023/06/20
- Product number
- J63250
- Product name
- MG 132
- Packaging
- 5mg
- Price
- $134
- Updated
- 2023/06/20
- Product number
- 10012628
- Product name
- (S)-MG132
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $20
- Updated
- 2024/03/01
MG-132 Chemical Properties,Usage,Production
Description
MG-132 (133407-82-6) is a specific inhibitor of the chymotrypsin-like activity of the 20S proteasome (IC50=100 nM with Z-LLL-AMC as substrate).1 Also inhibits calpain (IC50=1.25 μM).1 Suppresses gastric cancer cell proliferation and induces macro-autophagy.2 Activates stress kinases and induces Hsp72.3 Induces neurite outgrowth.1 MG-132 blocks NFκB activation by blocking IκB proteolysis (IC50=3 μM).4 Cell permeable.
Uses
A proteasome and NF-κB inhibitor.
Uses
MG 132 is a potent, membrane-permeable proteasome inhibitor. It induces neurite outgrowth in PC12 cells. Neuroprotective product.
Definition
ChEBI: A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is protected as its benzyloxycarbonyl derivative.
General Description
Potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1) and inhibits NF-κB activation (IC50 = 3 μM).
Biological Activity
Potent cell-permeable inhibitor of proteasome (IC 50 = 100 nM) and calpain (IC 50 = 1.2 μ M). Inhibits TNF- α -induced NF- κ B activation and I κ B α degradation. Induces neurite outgrowth in PC12 cells and has anticancer properties in vitro .
Biochem/physiol Actions
Cell permeable: yes
storage
-20°C (desiccate)
References
1) Tsubuki et al. (1996), Differential inhibition of calpain and proteasome activities by peptidyl aldehydes of di-leucine and tri-leucine; J. Biochem.,? 119 572 2) Wu? et al. (2010), Macroautophagy and ERK phosphorylation counteract the antiproliferative effect of proteasome inhibitor in gastric cancer cells; Autophagy, 6 228 3) Meriin? et al. (1998), Proteasome inhibitors activate stress kinases and induce Hsp72. Diverse effects on apoptosis; J. Biol. Chem., 273 6373 4) Fiedler et al. (1998), Inhibition of TNF-alpha-induced NF-kappaB activation and IL-8 release in A549 cells with the proteasome inhibitor MG-132; Am. J. Respir. Cell Mol. Biol., 19 259
MG-132 Preparation Products And Raw materials
Raw materials
Preparation Products
MG-132 Suppliers
- Tel
- 18122150900
- Fax
- QQ:2869377561
- sculk28@163.com
- Country
- China
- ProdList
- 646
- Advantage
- 55
- Tel
- 0571-87213919
- Fax
- 0571-87213919
- Eric@peptidego.com
- Country
- China
- ProdList
- 6968
- Advantage
- 58
- Tel
- 18914398991
- Fax
- 0513-81001007
- 1582941412@qq.com
- Country
- China
- ProdList
- 21
- Advantage
- 58
- Tel
- 18051384581
- sales@chemhifuture.com
- Country
- China
- ProdList
- 2998
- Advantage
- 58
- Tel
- 177-54423994 17754423994
- Fax
- QQ:2853530913
- 2853530910@QQ.com
- Country
- China
- ProdList
- 8012
- Advantage
- 62
- Tel
- Fax
- 86-21-57758967
- sales@boylechem.com
- Country
- China
- ProdList
- 2922
- Advantage
- 55
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 94657
- Advantage
- 76
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15839
- Advantage
- 69
- Tel
- 021-20221225 13917446399
- Fax
- QQ:115820162
- sales@zhiwe.net
- Country
- China
- ProdList
- 627
- Advantage
- 61
- Tel
- 512-58900862 400-0707518
- Fax
- 0086-512-56765862
- sales@alabiochem.com
- Country
- China
- ProdList
- 967
- Advantage
- 59
View Lastest Price from MG-132 manufacturers
- Product
- MG-132 133407-82-6
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.99%
- Supply Ability
- 2tons
- Release date
- 2019-12-19