MG-132
- Product Name
- MG-132
- CAS No.
- 133407-82-6
- Chemical Name
- MG-132
- Synonyms
- MG-132;CS-216;Z-LL-CHO;Z-LLL-al;Z-LLL-CHO;(S)-MG132;MG-132(SSS);MG132/MG-132;MG-132, >=98%;Z-LEU-LEU-LEU-H
- CBNumber
- CB3298042
- Molecular Formula
- C26H41N3O5
- Formula Weight
- 475.62
- MOL File
- 133407-82-6.mol
MG-132 Property
- Melting point:
- 80-84℃ (DEC.)
- alpha
- -61～-67°
- Boiling point:
- 682.0±55.0 °C(Predicted)
- Density
- 1.073
- Flash point:
- 366℃
- storage temp.
- -20°C
- solubility
- methanol: 1 mg/mL
- form
- solid film
- pka
- 11.14±0.46(Predicted)
- color
- White
- Water Solubility
- Soluble in ethanol, chloroform, methanol, water.
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO, DMF or ethanol may be stored at -20° for up to 1 week.
- InChIKey
- TZYWCYJVHRLUCT-VABKMULXSA-N
- SMILES
- C(N)(=O)[C@H](CC(C)C)N(C(=O)[C@H](CC(C)C)NC(OCC1=CC=CC=C1)=O)[C@H](C=O)CC(C)C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- 474790
- Product name
- MG-132
- Purity
- A cell-permeable, potent, reversible proteasome inhibitor (K
- Packaging
- 1mg
- Price
- $57.8
- Updated
- 2025/07/31
- Product number
- 474787
- Product name
- MG-132, ≥95% by HPLC
- Packaging
- 10mg
- Price
- $92
- Updated
- 2025/07/31
- Product number
- M3244
- Product name
- MG-132
- Packaging
- 10MG
- Price
- $100
- Updated
- 2025/07/31
- Product number
- 10012628
- Product name
- (S)-MG132
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $20
- Updated
- 2024/03/01
- Product number
- 10012628
- Product name
- (S)-MG132
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $62
- Updated
- 2024/03/01
MG-132 Chemical Properties,Usage,Production
Description
MG-132 (133407-82-6) is a specific inhibitor of the chymotrypsin-like activity of the 20S proteasome (IC50=100 nM with Z-LLL-AMC as substrate).1 Also inhibits calpain (IC50=1.25 μM).1 Suppresses gastric cancer cell proliferation and induces macro-autophagy.2 Activates stress kinases and induces Hsp72.3 Induces neurite outgrowth.1 MG-132 blocks NFκB activation by blocking IκB proteolysis (IC50=3 μM).4 Cell permeable.
Uses
A proteasome and NF-κB inhibitor.
Uses
MG 132 is a potent, membrane-permeable proteasome inhibitor. It induces neurite outgrowth in PC12 cells. Neuroprotective product.
Definition
ChEBI: A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is protected as its benzyloxycarbonyl derivative.
General Description
Potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1) and inhibits NF-κB activation (IC50 = 3 μM).
Biological Activity
Potent cell-permeable inhibitor of proteasome (IC 50 = 100 nM) and calpain (IC 50 = 1.2 μ M). Inhibits TNF- α -induced NF- κ B activation and I κ B α degradation. Induces neurite outgrowth in PC12 cells and has anticancer properties in vitro .
Biochem/physiol Actions
Cell permeable: yes
storage
-20°C (desiccate)
References
[1] S TSUBUKI. Differential inhibition of calpain and proteasome activities by peptidyl aldehydes of di-leucine and tri-leucine.[J]. Journal of biochemistry, 1996, 119 3: 572-576. DOI:10.1093/oxfordjournals.jbchem.a021280
[2] WILLIAM KA KEI WU. Macroautophagy and ERK phosphorylation counteract the antiproliferative effect of proteasome inhibitor in gastric cancer cells.[J]. Autophagy, 2010, 6 2: 228-238. DOI:10.4161/auto.6.2.11042
[3] A B MERIIN. Proteasome inhibitors activate stress kinases and induce Hsp72. Diverse effects on apoptosis.[J]. The Journal of Biological Chemistry, 1998, 273 11: 6373-6379. DOI:10.1074/jbc.273.11.6373
[4] M A FIEDLER J M S K Wernke Dollries. Inhibition of TNF-alpha-induced NF-kappaB activation and IL-8 release in A549 cells with the proteasome inhibitor MG-132.[J]. American Journal of Respiratory Cell and Molecular Biology, 1998, 19 2: 259-268. DOI:10.1165/ajrcmb.19.2.3149
MG-132 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from MG-132 manufacturers
- Product
- MG-132 133407-82-6
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.99%
- Supply Ability
- 2tons
- Release date
- 2019-12-19