KU-55933
- Product Name
- KU-55933
- CAS No.
- 587871-26-9
- Chemical Name
- KU-55933
- Synonyms
- CS-63;U-55933;KV-55933;KU 55933 NEW;KU-55933, >99%;KU 55933, >=98%;KU55933; KU 55933;KU-55933 USP/EP/BP;ATM Kinase Inhibitor;KU-55933 (ATM Kinase Inhibitor)
- CBNumber
- CB8503709
- Molecular Formula
- C21H17NO3S2
- Formula Weight
- 395.49
- MOL File
- 587871-26-9.mol
KU-55933 Property
- Boiling point:
- 628.0±55.0 °C(Predicted)
- Density
- 1.419±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml)
- form
- powder
- pka
- 0.33±0.20(Predicted)
- color
- white to beige
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML1109
- Product name
- KU-55933
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $103
- Updated
- 2024/03/01
- Product number
- SML1109
- Product name
- KU-55933
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $417
- Updated
- 2024/03/01
- Product number
- 16336
- Product name
- Ku-55933
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $28
- Updated
- 2024/03/01
- Product number
- 16336
- Product name
- Ku-55933
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $63
- Updated
- 2024/03/01
- Product number
- 16336
- Product name
- Ku-55933
- Purity
- ≥98%
- Packaging
- 25 mg
- Price
- $241
- Updated
- 2024/03/01
KU-55933 Chemical Properties,Usage,Production
Description
Potent and selective ATM kinase inhibitor IC50s= 13, 2500, 9300, 16600, >100000 and >100000 nM for ATM, DNA-PK, mTOR, PI 3-kinase, PI 4-K and ATR respectively.1Decreases viability of MCF-7, A549 and HCT116 cells and decreases p21CIP1?levels?in vitro.2?Disruption of ATM signaling in primary A-T fibroblasts leads to dysregulation of ribonucleotide reductase and increase resistance to inhibitors of mitochondrial respiration and translation.3?Sensitizes radio-resistant cancer cells.4Provides neuroprotection against H2O2-induced cell damage.5
Uses
A potent and specific ATM kinase inhibitor with an IC50 and a Ki of 13 nM and 2.2 nM, respectively.
Uses
KU-55933 has been used as an ataxia-telangiectasia mutated (Atm) inhibitor.
Definition
ChEBI: 2-(4-morpholinyl)-6-(1-thianthrenyl)-4-pyranone is a thianthrene.
Biological Activity
Potent, selective and competitive ATM kinase inhibitor (K i = 2.2 nM, IC 50 values are 13, 2500, 9300, 16600, > 100000 and > 100000 nM at ATM, DNA-PK, mTOR, PI 3-kinase, PI 4-K and ATR respectively). Decreases viability of MCF-7, A549 and HCT116 cells and decreases p21 CIP1 levels in vitro . Acts as a radio- and chemosensitizer for the treatment of cancer.
Biochem/physiol Actions
KU-55933 is a very potent, specific inhibitor of Ataxia telangiectasia (A-T) mutated (ATM) kinase (IC50 = 13 nM). KU-22933 treatment sensitizes cancer cells to ionizing radiation and cytotoxic drugs. The compound KU-22933 blocks ATM-mediated phosphorylyation of p53, gH2AX, NBS1, and SMC1.
storage
Desiccate at -20°C
References
1) Hickson?et al.?(2004),?Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM; Cancer Res.,?64?9152 2) Crescenzi?et al.?(2008),?Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: implications for chemotherapy; Clin. Cancer Res.?14?1877 3) Eaton?et al.?(2007),?Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasis; J. Clin. Invest.,?117?2723 4) Zhang?et al.?(2015)?The ATM inhibitor KU55933 sensitizes radioresistant bladder cancer cells with DAB2IP gene defect; Int. J. Radiat. Biol.,?91?368 5) Chwastek?et al.?(2017)?The ATM kinase inhibitor KU-55933 provides neuroprotection against hydrogen peroxide-induced cell damage via a yH2AX/p-p53/caspase-3-independent mechanism: Inhibition of calpain and cathepsin D; Int. J. Biochem. Cell Biol.?87?38
KU-55933 Preparation Products And Raw materials
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View Lastest Price from KU-55933 manufacturers
- Product
- KU55933;ku-55933 587871-26-9
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 98%+
- Supply Ability
- 10kgs
- Release date
- 2021-05-24
- Product
- KU-55933 587871-26-9
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-23