ChemicalBook > CAS DataBase List > KU-55933

KU-55933

Product Name
KU-55933
CAS No.
587871-26-9
Chemical Name
KU-55933
Synonyms
CS-63;U-55933;KV-55933;KU 55933 NEW;KU-55933, >99%;KU 55933, >=98%;KU55933; KU 55933;KU-55933 USP/EP/BP;ATM Kinase Inhibitor;KU-55933 (ATM Kinase Inhibitor)
CBNumber
CB8503709
Molecular Formula
C21H17NO3S2
Formula Weight
395.49
MOL File
587871-26-9.mol
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KU-55933 Property

Boiling point:
628.0±55.0 °C(Predicted)
Density 
1.419±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml)
form 
powder
pka
0.33±0.20(Predicted)
color 
white to beige
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1109
Product name
KU-55933
Purity
≥98% (HPLC)
Packaging
5MG
Price
$103
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1109
Product name
KU-55933
Purity
≥98% (HPLC)
Packaging
25MG
Price
$417
Updated
2024/03/01
Cayman Chemical
Product number
16336
Product name
Ku-55933
Purity
≥98%
Packaging
1mg
Price
$28
Updated
2024/03/01
Cayman Chemical
Product number
16336
Product name
Ku-55933
Purity
≥98%
Packaging
5mg
Price
$63
Updated
2024/03/01
Cayman Chemical
Product number
16336
Product name
Ku-55933
Purity
≥98%
Packaging
25 mg
Price
$241
Updated
2024/03/01
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KU-55933 Chemical Properties,Usage,Production

Description

Potent and selective ATM kinase inhibitor IC50s= 13, 2500, 9300, 16600, >100000 and >100000 nM for ATM, DNA-PK, mTOR, PI 3-kinase, PI 4-K and ATR respectively.1Decreases viability of MCF-7, A549 and HCT116 cells and decreases p21CIP1?levels?in vitro.2?Disruption of ATM signaling in primary A-T fibroblasts leads to dysregulation of ribonucleotide reductase and increase resistance to inhibitors of mitochondrial respiration and translation.3?Sensitizes radio-resistant cancer cells.4Provides neuroprotection against H2O2-induced cell damage.5

Uses

A potent and specific ATM kinase inhibitor with an IC50 and a Ki of 13 nM and 2.2 nM, respectively.

Uses

KU-55933 has been used as an ataxia-telangiectasia mutated (Atm) inhibitor.

Definition

ChEBI: 2-(4-morpholinyl)-6-(1-thianthrenyl)-4-pyranone is a thianthrene.

Biological Activity

Potent, selective and competitive ATM kinase inhibitor (K i = 2.2 nM, IC 50 values are 13, 2500, 9300, 16600, > 100000 and > 100000 nM at ATM, DNA-PK, mTOR, PI 3-kinase, PI 4-K and ATR respectively). Decreases viability of MCF-7, A549 and HCT116 cells and decreases p21 CIP1 levels in vitro . Acts as a radio- and chemosensitizer for the treatment of cancer.

Biochem/physiol Actions

KU-55933 is a very potent, specific inhibitor of Ataxia telangiectasia (A-T) mutated (ATM) kinase (IC50 = 13 nM). KU-22933 treatment sensitizes cancer cells to ionizing radiation and cytotoxic drugs. The compound KU-22933 blocks ATM-mediated phosphorylyation of p53, gH2AX, NBS1, and SMC1.

storage

Desiccate at -20°C

References

1) Hickson?et al.?(2004),?Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM; Cancer Res.,?64?9152 2) Crescenzi?et al.?(2008),?Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: implications for chemotherapy; Clin. Cancer Res.?14?1877 3) Eaton?et al.?(2007),?Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasis; J. Clin. Invest.,?117?2723 4) Zhang?et al.?(2015)?The ATM inhibitor KU55933 sensitizes radioresistant bladder cancer cells with DAB2IP gene defect; Int. J. Radiat. Biol.,?91?368 5) Chwastek?et al.?(2017)?The ATM kinase inhibitor KU-55933 provides neuroprotection against hydrogen peroxide-induced cell damage via a yH2AX/p-p53/caspase-3-independent mechanism: Inhibition of calpain and cathepsin D; Int. J. Biochem. Cell Biol.?87?38

KU-55933 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from KU-55933 manufacturers

Wuhan Nutra Biotechnology Co.,Ltd
Product
KU55933;ku-55933 587871-26-9
Price
US $0.00-0.00/g
Min. Order
1g
Purity
98%+
Supply Ability
10kgs
Release date
2021-05-24
Career Henan Chemical Co
Product
KU-55933 587871-26-9
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-23

587871-26-9, KU-55933Related Search:


  • 2-MORPHOLIN-4-YL-6-THIANTHREN-1-YL-PYRAN-4-ONE
  • 2-(4-Morpholinyl)-6-(1-thianthrenyl)-4H-pyran-4-one
  • KU-55933 (ATM Kinase Inhibitor)
  • KU-55933, >99%
  • KV-55933
  • 2-morpholino-6-(thianthren-1-yl)-4H-pyran-4-one
  • 2-Morpholin-4-yl-6-thianthren-1-ylpyran-4-one KU-55933 (ATM Kinase Inhibitor)
  • KU 55933, >=98%
  • U-55933
  • ATM Kinase Inhibitor
  • KU-55933 (ATM KINASE INHIBITOR);KU 55933; KU55933
  • CS-63
  • KU55933; KU 55933
  • KU 55933 NEW
  • 4H-Pyran-4-one, 2-(4-morpholinyl)-6-(1-thianthrenyl)-
  • KU-55933 USP/EP/BP
  • ATM Kinase Inhibitor Ku-55933 Ku55933
  • KU55933,Inhibitor,inhibit,Ataxia telangiectasia mutated,KU-55933,KU 55933,ATM/ATR,ATM and RAD3 related,Autophagy
  • 587871-26-9
  • C21H17NO3S2
  • Inhibitors