CX-4945
- Product Name
- CX-4945
- CAS No.
- 1009820-21-6
- Chemical Name
- CX-4945
- Synonyms
- CX-4945;CS-1985;Silmitasertib;CX-4945, >=98%;CX-4945, CX4945;mitasertib (CX-4945);SPIROBIINDANE CX-4945;Silmitasertib(CX-4945);CX-4945 Silmitasertib;CX-4945 Silmitasertib CX4945
- CBNumber
- CB62473893
- Molecular Formula
- C19H12ClN3O2
- Formula Weight
- 349.77
- MOL File
- 1009820-21-6.mol
CX-4945 Property
- Boiling point:
- 568.5±50.0 °C(Predicted)
- Density
- 1.490
- storage temp.
- Store at -20°C
- solubility
- ≥103.5 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
- form
- Orange powder.
- pka
- 2.96±0.30(Predicted)
Safety
- HS Code
- 29339900
N-Bromosuccinimide Price
- Product number
- 16779
- Product name
- CX-4945
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 16779
- Product name
- CX-4945
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 16779
- Product name
- CX-4945
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $206
- Updated
- 2024/03/01
- Product number
- 16779
- Product name
- CX-4945
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $346
- Updated
- 2024/03/01
- Product number
- C858600
- Product name
- CX-4945
- Packaging
- 50mg
- Price
- $910
- Updated
- 2021/12/16
CX-4945 Chemical Properties,Usage,Production
Uses
CX-4945 is a protein kinase CK2 inhibitor resulting in cancer cell death and prevention of proliferation. Anti-leukemia agent.
Biological Activity
cx-4945 (silmitasertib) is a potent and selective casein kinase 2 (ck2) inhibitor with ic50 value of 1 nm. it is atp-competitive and can be taken orally [1].cx-4945 has been reported to have antiproliferative activity against a wide range of tumor cell lines. it is suggested that cx-4945 suppresses the ck2 regulated pi3k/akt signaling pathway by inhibiting akt phosphorylation at serine 129, but not by activating pten. additionally, cells treated with cx-4945 had a reduction of p21 phophorylation and an up-regulations of total p21 and p27. cx-4945 has been shown to induce cell-cycle arrest at g2/m phase in breast cancer cell line bt-474. it also causes cell-cycle arrest at g1 phase the breast cancer cell line bxpc-3) [1].in cx-4945 and bxpc-3 derived mouse xenograft model, cx-4945 induced a reduction of phos-p21 expression along with anti-carcinoma effects [1]
References
[1] siddiqui-jain a1, drygin d, streiner n, chua p, pierre f, o'brien se, bliesath j, omori m, huser n, ho c, proffitt c, schwaebe mk, ryckman dm, rice wg,anderes k. cx-4945, an orally bioavailable selective inhibitor of protein kinase ck2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy. cancer res. 2010 dec 15; 70 (24): 10288-98.
CX-4945 Preparation Products And Raw materials
Raw materials
Preparation Products
CX-4945 Suppliers
View Lastest Price from CX-4945 manufacturers
- Product
- 5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylic acid 1009820-21-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2019-12-23