ChemicalBook > CAS DataBase List > ACY-1215

ACY-1215

Product Name
ACY-1215
CAS No.
1316214-52-4
Chemical Name
ACY-1215
Synonyms
ACY 63;CS-583;ACY-1215;Propane-1;Ricolinostat;Rocilinostat;ACY-1215/ACY1215;Rocilinostat, >=99%;3-tricarboxylic acid;β-Carboxyglutaric acid
CBNumber
CB82627292
Molecular Formula
C24H27N5O3
Formula Weight
433.5
MOL File
1316214-52-4.mol
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ACY-1215 Property

Melting point:
189 - 191°C
Density 
1.239±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
9.47±0.20(Predicted)
form 
Solid
color 
White to Off-White
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21531
Product name
ACY-1215
Purity
≥98%
Packaging
25mg
Price
$72
Updated
2024/03/01
Cayman Chemical
Product number
21531
Product name
ACY-1215
Purity
≥98%
Packaging
50mg
Price
$129
Updated
2024/03/01
Cayman Chemical
Product number
21531
Product name
ACY-1215
Purity
≥98%
Packaging
100mg
Price
$228
Updated
2024/03/01
Cayman Chemical
Product number
21531
Product name
ACY-1215
Purity
≥98%
Packaging
250mg
Price
$494
Updated
2024/03/01
TRC
Product number
D486990
Product name
2-(Diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide
Packaging
250mg
Price
$275
Updated
2021/12/16
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ACY-1215 Chemical Properties,Usage,Production

Description

ACY-1215 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 5 nM). It is at least 10-fold less active against other HDACs in enzymatic assays. ACY-1215 shows synergistic activity with the proteasome inhibitor bortezomib against multiple myeloma (MM) cells, inducing protracted endoplasmic reticulum stress and apoptosis. ACY-1215 combined with proteasome inhibitors suppresses tumor growth and increases survival in mice with MM and mantle cell lymphoma xenografts. A multicenter phase I trial examining ACY-1215 combined with the E3 ligase inhibitor lenalidomide and dexamethasone in multiple myeloma found inhibition of HDAC6 in vivo. ACY-1215 also diminishes liver cyst development and fibrosis in a rat model of polycystic liver disease.

Uses

This compound acts as a selective HDAC-6 (histone deacetylase) inihibitor. HDAC is linked to the transcription of DNA in cancers, including multiple myeloma (MM).

Definition

ChEBI: N-[7-(hydroxyamino)-7-oxoheptyl]-2-(N-phenylanilino)-5-pyrimidinecarboxamide is a pyrimidinecarboxylic acid.

target

HDAC6

ACY-1215 Preparation Products And Raw materials

Raw materials

Preparation Products

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ACY-1215 Suppliers

Canada 1 China 143 India 1 United Kingdom 1 United States 18 Global 164
Shanghai Boyle Chemical Co., Ltd.
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View Lastest Price from ACY-1215 manufacturers

Shaanxi Haibo Biotechnology Co., Ltd
Product
ACY-1215 1316214-52-4
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000ton
Release date
2023-08-29
Henan Aochuang Chemical Co.,Ltd.
Product
ACY-1215 1316214-52-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-13

1316214-52-4, ACY-1215Related Search:

Panobinostat Mocetinostat (MGCD0103) Tubastatin-A Tubastatin A hydrochloride Entinostat Crizotinib

  • Rocilinostat (ACY-1215)
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  • 2- (Diphenylamino) - N - [7- (hydroxyamino) -7-oxoheptyl] -5-pyrimidine carboxylamide
  • 1316214-52-4
  • Inhibitors
  • Inhibitor