HC TOXIN

ChemicalBook > CAS DataBase List > HC TOXIN

Product Name: HC TOXIN
CAS No.: 83209-65-8
Chemical Name: HC TOXIN
Synonyms: Toxin I;HC TOXIN;HC toxin I;Cyclo(aoe-Pro-Ala-ala);HC TOXIN FROM HELMINTHOSPORIUM CARBONUM;HC Toxin, histone deacetylase (HDAC) inhibitor;Cyclo[D-Pro-L-Ala-D-Ala-2-(6-oxo-6-oxiranylhexyl)-L-Gly-];CYCLO-(D-PRO-L-ALA-D-ALA-L-2-AMINO-8-OXO-9,10-EPOXYDECANOIC ACID);Cyclo[L-Ala-D-Ala-[(2S)-2-amino*-8-oxo-8-oxiranyloctanoyl]-D-Pro-];Cyclo(2-amino-8-oxo-9,10-epoxydecanoic acid-prolyl-alanyl-alanine)
CBNumber: CB2460604
Molecular Formula: C21H32N4O6
Formula Weight: 436.51
MOL File: 83209-65-8.mol

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HC TOXIN Property

Boiling point:: 819.2±65.0 °C(Predicted)
Density: 1.28±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: 10 mg/ml; Methanol: 10 mg/ml
form: lyophilized powder
pka: 13.33±0.70(Predicted)
color: Off-white to light yellow

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H7270
Product name: HC toxin from Helminthosporium carbonum
Purity: lyophilized powder
Packaging: 5mg
Price: $767
Updated: 2022/05/15

Cayman Chemical

Product number: 10576
Product name: HC Toxin
Purity: ≥95%
Packaging: 500μg
Price: $97
Updated: 2024/03/01

Cayman Chemical

Product number: 10576
Product name: HC Toxin
Purity: ≥95%
Packaging: 1mg
Price: $165
Updated: 2024/03/01

Cayman Chemical

Product number: 10576
Product name: HC Toxin
Purity: ≥95%
Packaging: 5mg
Price: $721
Updated: 2024/03/01

TRC

Product number: H115005
Product name: HCToxin
Packaging: 5mg
Price: $1540
Updated: 2021/12/16

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HC TOXIN Chemical Properties,Usage,Production

Description

HC Toxin is a cell-permeable, reversible inhibitor of histone deacetylases (HDACs) (IC₅₀ = 30 nM). Through its effects on HDACs, HC toxin has been shown to up-regulate the expression of 15-lipoxygenase-1 in colorectal cancer cells and induce fetal hemoglobin in human primary erythroid cells. HC Toxin is a cyclic tetrapeptide first isolated from H. carbonum (now C. carbonum), a pathogen of maize.

Uses

HC Toxin is an HDAC inhibitor. Cyclic tetrapeptide[1] fungal toxin selectively toxic to plants with susceptible host genotype (2)

Definition

ChEBI: A homodetic cyclic tetrapeptide made up from L-alanyl, D-alanyl, L-prolyl and 2-amino-8-oxo-9,10-epoxydecanoyl residues.

Biochem/physiol Actions

Cyclic tetrapeptide fungal toxin selectively toxic to plants with susceptible host genotype.

HC TOXIN Preparation Products And Raw materials

Raw materials

Preparation Products

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HC TOXIN Suppliers

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83209-65-8, HC TOXINRelated Search:

Sodium Butyrate Suberohydroxamic acid 1H-Benz[de]isoquinoline-2(3H)-butanamide SCRIPTAID SPLITOMICIN Sodium 4-phenylbutyrate BENZOTRIAZOL-1-YL-(2,4-DICHLORO-PHENYL)-METHANONE APICIDIN CAY10603 OXAMFLATIN Tubacin Entinostat M344 Parthenolide HC TOXIN Cyclen N-OCTYL PYRROLIDINE Acetamide, N-(2-(nonylamino)ethyl)-

HC TOXIN FROM HELMINTHOSPORIUM CARBONUM

Cyclo[D-Pro-L-Ala-D-Ala-2-(6-oxo-6-oxiranylhexyl)-L-Gly-]

Cyclo[L-Ala-D-Ala-[(2S)-2-amino*-8-oxo-8-oxiranyloctanoyl]-D-Pro-]

HC toxin I

Toxin I

Cyclic(L-alanyl-D-alanyl-eta-oxo-L-alpha-aminooxiraneoctanoyl-D-prolyl)

Cyclo(2-amino-8-oxo-9,10-epoxydecanoic acid-prolyl-alanyl-alanine)

Cyclo(aoe-Pro-Ala-ala)

Cyclo(L-alanyl-D-alanyl-(alphas,2S)-alpha-amino-eta-oxooxiraneoctanoyl-D-prolyl)

Cyclo(L-alanyl-D-alanyl-8-oxiranyl-8-oxo-L-2-aminooctanoyl-D-prolyl), (S)-

(3S,6R,9S,12R)-6,9-dimethyl-3-[6-[(2S)-oxiran-2-yl]-6-oxohexyl]-1,4,7,10-tetrazabicyclo[10.3.0]pentadecane-2,5,8,11-tetrone

CYCLO-(D-PRO-L-ALA-D-ALA-L-2-AMINO-8-OXO-9,10-EPOXYDECANOIC ACID)

HC TOXIN

HC Toxin, histone deacetylase (HDAC) inhibitor

83209-65-8

C21H32N4O6

Cell Signaling and Neuroscience

Mold

Toxins and Venoms