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HC TOXIN

Product Name
HC TOXIN
CAS No.
83209-65-8
Chemical Name
HC TOXIN
Synonyms
Toxin I;HC TOXIN;HC toxin I;Cyclo(aoe-Pro-Ala-ala);HC TOXIN FROM HELMINTHOSPORIUM CARBONUM;HC Toxin, histone deacetylase (HDAC) inhibitor;Cyclo[D-Pro-L-Ala-D-Ala-2-(6-oxo-6-oxiranylhexyl)-L-Gly-];CYCLO-(D-PRO-L-ALA-D-ALA-L-2-AMINO-8-OXO-9,10-EPOXYDECANOIC ACID);Cyclo[L-Ala-D-Ala-[(2S)-2-amino*-8-oxo-8-oxiranyloctanoyl]-D-Pro-];Cyclo(2-amino-8-oxo-9,10-epoxydecanoic acid-prolyl-alanyl-alanine)
CBNumber
CB2460604
Molecular Formula
C21H32N4O6
Formula Weight
436.51
MOL File
83209-65-8.mol
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HC TOXIN Property

Boiling point:
819.2±65.0 °C(Predicted)
Density 
1.28±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: 10 mg/ml; Methanol: 10 mg/ml
form 
lyophilized powder
pka
13.33±0.70(Predicted)
color 
Off-white to light yellow
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H7270
Product name
HC toxin from Helminthosporium carbonum
Purity
lyophilized powder
Packaging
5mg
Price
$767
Updated
2022/05/15
Cayman Chemical
Product number
10576
Product name
HC Toxin
Purity
≥95%
Packaging
500μg
Price
$97
Updated
2024/03/01
Cayman Chemical
Product number
10576
Product name
HC Toxin
Purity
≥95%
Packaging
1mg
Price
$165
Updated
2024/03/01
Cayman Chemical
Product number
10576
Product name
HC Toxin
Purity
≥95%
Packaging
5mg
Price
$721
Updated
2024/03/01
TRC
Product number
H115005
Product name
HCToxin
Packaging
5mg
Price
$1540
Updated
2021/12/16
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HC TOXIN Chemical Properties,Usage,Production

Description

HC Toxin is a cell-permeable, reversible inhibitor of histone deacetylases (HDACs) (IC50 = 30 nM). Through its effects on HDACs, HC toxin has been shown to up-regulate the expression of 15-lipoxygenase-1 in colorectal cancer cells and induce fetal hemoglobin in human primary erythroid cells. HC Toxin is a cyclic tetrapeptide first isolated from H. carbonum (now C. carbonum), a pathogen of maize.

Uses

HC Toxin is an HDAC inhibitor. Cyclic tetrapeptide[1] fungal toxin selectively toxic to plants with susceptible host genotype (2)

Definition

ChEBI: A homodetic cyclic tetrapeptide made up from L-alanyl, D-alanyl, L-prolyl and 2-amino-8-oxo-9,10-epoxydecanoyl residues.

Biochem/physiol Actions

Cyclic tetrapeptide fungal toxin selectively toxic to plants with susceptible host genotype.

HC TOXIN Preparation Products And Raw materials

Raw materials

Preparation Products

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HC TOXIN Suppliers

China 51 Switzerland 2 United States 9 USA 1 Global 63

83209-65-8, HC TOXINRelated Search:

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  • HC TOXIN FROM HELMINTHOSPORIUM CARBONUM
  • Cyclo[D-Pro-L-Ala-D-Ala-2-(6-oxo-6-oxiranylhexyl)-L-Gly-]
  • Cyclo[L-Ala-D-Ala-[(2S)-2-amino*-8-oxo-8-oxiranyloctanoyl]-D-Pro-]
  • HC toxin I
  • Toxin I
  • Cyclic(L-alanyl-D-alanyl-eta-oxo-L-alpha-aminooxiraneoctanoyl-D-prolyl)
  • Cyclo(2-amino-8-oxo-9,10-epoxydecanoic acid-prolyl-alanyl-alanine)
  • Cyclo(aoe-Pro-Ala-ala)
  • Cyclo(L-alanyl-D-alanyl-(alphas,2S)-alpha-amino-eta-oxooxiraneoctanoyl-D-prolyl)
  • Cyclo(L-alanyl-D-alanyl-8-oxiranyl-8-oxo-L-2-aminooctanoyl-D-prolyl), (S)-
  • (3S,6R,9S,12R)-6,9-dimethyl-3-[6-[(2S)-oxiran-2-yl]-6-oxohexyl]-1,4,7,10-tetrazabicyclo[10.3.0]pentadecane-2,5,8,11-tetrone
  • CYCLO-(D-PRO-L-ALA-D-ALA-L-2-AMINO-8-OXO-9,10-EPOXYDECANOIC ACID)
  • HC TOXIN
  • HC Toxin, histone deacetylase (HDAC) inhibitor
  • 83209-65-8
  • C21H32N4O6
  • Cell Signaling and Neuroscience
  • Mold
  • Toxins and Venoms