Diethylenetriamine Property

Melting point:

-40 °C

Boiling point:

206 °C

Density 

0.955 g/mL at 25 °C(lit.)

vapor density 

3.6 (vs air)

vapor pressure 

0.08 mm Hg ( 20 °C)

refractive index 

n20/D 1.484(lit.)

Flash point:

90 °C

storage temp. 

Store below +30°C.

solubility 

Chloroform (Soluble), Methanol (Slightly)

pka

pK1:4.42(+3);pK2:9.21(+2);pK3:10.02(+1) (25°C)

form 

Liquid

color 

Clear

Odor

Strong ammoniacal; mildly ammoniacal.

PH

>12 (100g/l, H2O, 20℃)

explosive limit

1-10%(V)

Water Solubility 

miscible

Sensitive 

Air Sensitive

BRN 

605314

Exposure limits

ACGIH: TWA 1 ppm (Skin)
NIOSH: TWA 1 ppm(4 mg/m3)

Stability:

Stable, but absorbs carbon dioxide from the air. Incompatible with strong oxidizing agents, copper and its alloys.

InChIKey

RPNUMPOLZDHAAY-UHFFFAOYSA-N

LogP

-1.58 at 20℃

CAS DataBase Reference

111-40-0(CAS DataBase Reference)

NIST Chemistry Reference

1,2-Ethanediamine, N-(2-aminoethyl)-(111-40-0)

EPA Substance Registry System

Diethylenetriamine (111-40-0)

Safety

Hazard Codes 

C,T+

Risk Statements 

21/22-34-43-37-26

Safety Statements 

26-36/37/39-45-28

RIDADR 

UN 2079 8/PG 2

WGK Germany 

2

RTECS 

IE1225000

Autoignition Temperature

676 °F

TSCA 

Yes

HazardClass 

8

PackingGroup 

II

HS Code 

29212900

Hazardous Substances Data

111-40-0(Hazardous Substances Data)

Toxicity

LD50 orally in Rabbit: 1540 mg/kg

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

H317May cause an allergic skin reaction

H330Fatal if inhaled

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Diethylenetriamine Chemical Properties,Usage,Production

Description

Diethylenetriamine is a hardener in epoxy resins of the Bisphenol A type. It has been reported as a sensitizer in ultrasonic baths for cleaning jewels, in synthetic lubricants and in carbonless copy paper.

Chemical Properties

Diethylenetriamine is a corrosive yellow liquid and a solvent. It has a strong ammonia odor and is prone to absorbing moisture. It can dissolve in water, acetone, benzene, ether, methanol, but is not soluble in n-heptane.

Uses

Diethylenetriamine is a solvent for sulfur, acidic gas, resin and dye intermediates for organic synthesis; saponification agent for acidic materials; fuel component; hardener for epoxy resins.

Production Methods

Diethylenetriamine is produced by the reaction of ethylene dichloride with ammonia. Diethylenetriamine is used in biological studies, for polyamines inhibition to carbonic anhydrases by anchoring to the zinc-coordinated water molecule.

Definition

ChEBI: Diethylenetriamine is a triamine and a polyazaalkane.

Synthesis Reference(s)

Journal of the American Chemical Society, 105, p. 5002, 1983 DOI: 10.1021/ja00353a025

General Description

A yellow liquid with an ammonia-like odor. Less dense than water. Corrosive to metals and tissue. Vapors heavier than air. Burns, although possibly difficult to igntie. Toxic oxides of nitrogen produced during combustion. Used as a solvent for plastics and dyes and in chemical synthesis.

Air & Water Reactions

Soluble in water.

Reactivity Profile

Diethylenetriamine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Health Hazard

Prolonged breathing of vapors may cause asthma. Liquid burns skin and eyes. A skin rash can form.

Health Hazard

Brief contact with concentrated diethylenetriamine can produce severe local injury to the eyes and skin resembling the effect from strong base. Human subjects are susceptible to sensitization responses either as dermatitis or an asthma-like response. A time-weighted average of 1 p.p.m. is recommenced for diethylenetriamine (ACGIH 1986).

Fire Hazard

Special Hazards of Combustion Products: Irritating vapors are generated when heated.

Flammability and Explosibility

Non flammable

Industrial uses

Diethylenetriamine is used as an intermediate in the production of reactive polyamide resins, and in the production of aminoamides and imidazolines from fatty acids. It is also used in the production of paper wet strength resins and piperazine. Diethylenetriamine serves as a solvent for sulfur, acid gases, resins and dyes (HSDB 1989).

Contact allergens

Diethylenetriamine is a hardener in epoxy resins of the Bisphenol A type. It has been reported to be a sensitizer when used in an ultrasonic bath for cleaning jewels, in synthetic lubricants, or in carbonless copy paper.

Safety Profile

Poison by skin contact and intraperitoneal routes. Moderately toxic by ingestion. Corrosive. A severe skin and eye irritant. High concentration of vapors causes irritation of respiratory tract, nausea, and vomiting. Repeated exposures can cause asthma and sensitization of skin. Combus uble when exposed to heat or flame; can react with oxidizing materials. Mxture with nitromethane is a shock-sensitive explosive. Ignites on contact with cellulose nitrate of high surface area. To fight fire, use alcohol foam. When heated to decomposition it emits toxic fumes of NOx. See also AMINES.

Potential Exposure

PrimaryIrritant. This material is used in textile finishes, fungicides,corrosion inhibitors, adhesives, asphalt additives, as a solvent for sulfur, acid gases, resins, and dyes.

First aid

If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. If victim is conscious, administer water ormilk. Do not induce vomiting.

Carcinogenicity

DETA has a strong ammonia-like odor, but it does not provide adequate warning of hazardous concentrations.
The 2003 ACGIH threshold limit valuetime- weighted average (TLV-TWA) for diethylene triamine is 1ppm (4.2mg/m3) with a notation for skin absorption.

Metabolism

Diethylenetriamine is readily absorbed through the gastrointestinal tract and 96% of the administered dose is excreted within 48 h (USEPA 1983a). Roughly equal amounts are excreted in the feces and urine with at least 4 metabolites being detected (but not identified) in the latter. Only a small proportion (<2%) was recovered as expired carbon dioxide. Any residual remaining in the animal was found primarily in kidney, liver, bladder and large intestine.

storage

Color Code—White: Corrosive or Contact Hazard;Store separately in a corrosion-resistant location. Prior to working with this chemical you should be trained on itsproper handling and storage. Before entering confined spacewhere this chemical may be present, check to make surethat an explosive concentration does not exist. Store intightly closed containers in a cool, well-ventilated areaaway from acids, halogenated organics, and oxidizers (suchas perchlorates, peroxides, chlorates, nitrates, and permanganates). Protect containers from physical damage. Sourcesof ignition, such as smoking and open flames, are prohibited where this chemical is used, handled, or stored in amanner that could create a potential fire or explosion hazard. Metal containers involving the transfer of=gallons ormore of this chemical should be grounded and bonded.Drums must be equipped with self-closing valves, pressurevacuum bungs, and flame arresters. Use only nonsparkingtools and equipment, especially when opening and closingcontainers of this chemical.

Shipping

This material requires a “CORROSIVE” label. Itfalls in Hazard Class 8 and Packing Group II.

Purification Methods

Dry the amine with Na and distil, preferably under reduced pressure, or in a stream of N2. [Beilstein 4 IV 1284.]

Incompatibilities

Forms explosive mixture with air. Ignitesspontaneously on contact with cellulose nitrate. Contact withsilver, cobalt, or chromium compounds may cause explosions.Incompatible with acids, halogenated organics, organic anhydrides, isocyanates, vinyl acetate, acrylates, substituted allyls,alkylene oxides, epichlorohydrin, ketones, aldehydes, alcohols, glycols, mercury, phenols, cresols, caprolactum solution,strong oxidizers. Attacks aluminum, copper, copper alloys,lead, tin, zinc and alloys.