ChemicalBook > CAS DataBase List > N,N,N',N'-Tetramethylethylenediamine

N,N,N',N'-Tetramethylethylenediamine

Product Name
N,N,N',N'-Tetramethylethylenediamine
CAS No.
110-18-9
Chemical Name
N,N,N',N'-Tetramethylethylenediamine
Synonyms
TMEDA;TEMED;TETRAMETHYLETHYLENEDIAMINE;N1,N1,N2,N2-tetraMethylethane-1,2-diaMine;TMED;1,4-DIAMINOBUTANE;TD;1,2-BIS(DIMETHYLAMINO)ETHANE;2,5-DiMethyl-2,5-diazahexane;N,N,N',N'-TETRAMETHYLENEDIAMINE
CBNumber
CB2446761
Molecular Formula
C6H16N2
Formula Weight
116.2
MOL File
110-18-9.mol
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N,N,N',N'-Tetramethylethylenediamine Property

Melting point:
−55 °C(lit.)
Boiling point:
120-122 °C(lit.)
Density 
0.775 g/mL at 20 °C(lit.)
vapor density 
4 (vs air)
vapor pressure 
21 hPa (20 °C)
refractive index 
n20/D 1.4179(lit.)
Flash point:
50 °F
storage temp. 
Store below +30°C.
solubility 
H2O: 10 mg/mL at 20 °C, clear, colorless
form 
Liquid
pka
10.40, 8.26(at 25℃)
Specific Gravity
0.777 (20/4℃)
color 
Clear colorless to slightly yellow
Odor
Amine like
PH
8.0-8.5 (0.1g/l, H2O, 20℃)
explosive limit
1-9%(V)
Water Solubility 
miscible
Sensitive 
Hygroscopic
Merck 
14,9134
BRN 
1732991
Stability:
Stable. Highly flammable. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides, copper, mercury.
InChIKey
DMQSHEKGGUOYJS-UHFFFAOYSA-N
LogP
-0.13 at 20.2℃
CAS DataBase Reference
110-18-9(CAS DataBase Reference)
NIST Chemistry Reference
1,2-Ethanediamine, N,N,N',N'-tetramethyl-(110-18-9)
EPA Substance Registry System
Tetramethylethylenediamine (110-18-9)
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Safety

Hazard Codes 
F,C,Xi
Risk Statements 
11-20/22-34-20/21/22
Safety Statements 
16-26-36/37/39-45
RIDADR 
UN 2372 3/PG 2
WGK Germany 
1
RTECS 
KV7175000
3-8-10-34
Autoignition Temperature
145 °C
Hazard Note 
Irritant
TSCA 
Yes
HazardClass 
3
PackingGroup 
II
HS Code 
29212900
Hazardous Substances Data
110-18-9(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.08742
Product name
N,N,N′,N′-Tetramethyl ethylenediamine
Purity
for synthesis
Packaging
5ml
Price
$32.3
Updated
2024/03/01
Sigma-Aldrich
Product number
8.08742
Product name
N,N,N′,N′-Tetramethyl ethylenediamine
Purity
for synthesis
Packaging
250ML
Price
$55.9
Updated
2024/03/01
Sigma-Aldrich
Product number
8.08742
Product name
N,N,N′,N′-Tetramethyl ethylenediamine
Purity
for synthesis
Packaging
1L
Price
$179
Updated
2024/03/01
Sigma-Aldrich
Product number
411019
Product name
N,N,N′,N′-Tetramethyl ethylenediamine
Purity
≥99.5%, purified by redistillation
Packaging
2l
Price
$347.6
Updated
2024/03/01
Sigma-Aldrich
Product number
411019
Product name
N,N,N′,N′-Tetramethyl ethylenediamine
Purity
≥99.5%, purified by redistillation
Packaging
1l
Price
$453
Updated
2024/03/01
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N,N,N',N'-Tetramethylethylenediamine Chemical Properties,Usage,Production

Chemical Properties

Colorless to slightly yellow liquid

Uses

N,N,N',N'-Tetramethylethylenediamine is used as polymerization accelerator in gel electrophoresis, solvent and oxidizing reagent. It is also used for the separation of proteins or nucleic acids. Further, it is employed as a ligand for metal ions like zinc and copper. It is actively involved in the formation of anionic organometallic complex.

Definition

ChEBI: N,N,N',N'-tetramethylethylenediamine is an ethylenediamine derivative in which each nitrogen carries two methyl substituents. It is widely employed both as a ligand for metal ions and as a catalyst in organic polymerisation. It has a role as a chelator and a catalyst.

General Description

1,2-di-(dimethylamino)ethane appears as a water-white colored liquid with a fishlike odor. Flash point 68 °F. Less dense than water. Vapors heavier than air. Used to make other chemicals.

Air & Water Reactions

Highly flammable. Slightly soluble in water. Sensitive to heat and may be sensitive to air .

Reactivity Profile

N,N,N',N'-Tetramethylethylenediamine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Health Hazard

May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Safety Profile

Moderately toxic by ingestion. Mddly toxic by slun contact. A skin and severe eye irritant. Flammable when exposed to heat or flame; can react with oxidizing materials. When heated to decomposition it emits toxic fumes of NOx. See also MINES.

Purification Methods

Dry TMEDA partially with molecular sieves (Linde type 4A), then distil it in a vacuum from butyl lithium. This treatment removes all traces of primary and secondary amines and water. [Hay et al. J Chem Soc, Faraday Trans 1 68 1 1972.] Or dry it with KOH pellets, reflux for 2hours with one-sixth its weight of n-butyric anhydride (to remove primary and secondary amines) and fractionally distil it. Reflux it with fresh KOH, and distil it under nitrogen. [Cram & Wilson J Am Chem Soc 85 1245 1963.] It was also distilled from Na. Store it sealed under N2. The dipicrate has m 263o(dec). [Beilstein 4 H 250, 4 I 415, 4 II 690, 4 III 512, 4 IV 1172.]

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N,N,N',N'-Tetramethylethylenediamine Suppliers

SHANGHAI BANGCHENG CHEMICAL Co.,Ltd.
Tel
021-69106960 13701823733
Fax
021-69106780
Email
13701823733@163.com
Country
China
ProdList
4767
Advantage
60
Zhangjiagang hambadu chemical co. LTD
Tel
0512-58923008 13862226968
Email
yf@halberdo.com
Country
China
ProdList
2
Advantage
58
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Shanghai Harvest Chemical Industrial Co., Ltd.
Tel
21-31038972 15721252604
Fax
+86-21-51385350
Email
ammyzuo@harvest-chem.com
Country
China
ProdList
2540
Advantage
64
Shanghai Xinyue Chemical Co., Ltd.
Tel
18116267768
Fax
021-51685846
Email
645908973@qq.com
Country
China
ProdList
76
Advantage
58
Yikang Chemical(Hubei)Co., LTD
Tel
027-18971353-902 18971353902
Email
2242508613@qq.com
Country
China
ProdList
7871
Advantage
58
Shandong Zhenkun New Material Co., LTD
Tel
133-3635-7633 13683127222
Fax
13683127222
Email
277809310@qq.com
Country
China
ProdList
51
Advantage
58
Shanghai Yanze Chemical Co., Ltd.
Tel
021-13773155751 19975051755
Email
260924549@qq.com
Country
China
ProdList
8904
Advantage
58
Beijing InnoChem Science & Technology Co., Ltd.
Tel
15652467323 15652467323
Email
sales@inno-chem.com.cn
Country
China
ProdList
8293
Advantage
58
Shandong Luoheng Chemical Products Co. , Ltd.
Tel
17362288188
Email
270788802@qq.com
Country
China
ProdList
55
Advantage
58
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View Lastest Price from N,N,N',N'-Tetramethylethylenediamine manufacturers

Hebei Dangtong Import and export Co LTD
Product
N,N,N',N'-Tetramethylethylenediamine 110-18-9
Price
US $60.00-55.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20Tons
Release date
2023-10-11
Hebei Chuanghai Biotechnology Co,.LTD
Product
N,N,N',N'-Tetramethylethylenediamine 110-18-9
Price
US $10.00/KG
Min. Order
1KG
Purity
99.%
Supply Ability
10 ton
Release date
2024-08-05
Hebei Weibang Biotechnology Co., Ltd
Product
N,N,N',N'-Tetramethylethylenediamine 110-18-9
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2021-07-20

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