N,N,N',N'-Tetramethylethylenediamine Property

Melting point:

−55 °C(lit.)

Boiling point:

120-122 °C(lit.)

Density 

0.775 g/mL at 20 °C(lit.)

vapor density 

4 (vs air)

vapor pressure 

21 hPa (20 °C)

refractive index 

n20/D 1.4179(lit.)

Flash point:

50 °F

storage temp. 

Store below +30°C.

solubility 

H₂O: 10 mg/mL at 20 °C, clear, colorless

form 

Liquid

pka

10.40, 8.26(at 25℃)

Specific Gravity

0.777 (20/4℃)

color 

Clear colorless to slightly yellow

Odor

Amine like

PH

8.0-8.5 (0.1g/l, H2O, 20℃)

explosive limit

1-9%(V)

Water Solubility 

miscible

Sensitive 

Hygroscopic

Merck 

14,9134

BRN 

1732991

Stability:

Stable. Highly flammable. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides, copper, mercury.

InChIKey

DMQSHEKGGUOYJS-UHFFFAOYSA-N

LogP

-0.13 at 20.2℃

CAS DataBase Reference

110-18-9(CAS DataBase Reference)

NIST Chemistry Reference

1,2-Ethanediamine, N,N,N',N'-tetramethyl-(110-18-9)

EPA Substance Registry System

Tetramethylethylenediamine (110-18-9)

Safety

Hazard Codes 

F,C,Xi

Risk Statements 

11-20/22-34-20/21/22

Safety Statements 

16-26-36/37/39-45

RIDADR 

UN 2372 3/PG 2

WGK Germany 

1

RTECS 

KV7175000

F 

3-8-10-34

Autoignition Temperature

145 °C

Hazard Note 

Irritant

TSCA 

Yes

HazardClass 

3

PackingGroup 

II

HS Code 

29212900

Hazardous Substances Data

110-18-9(Hazardous Substances Data)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

N,N,N',N'-Tetramethylethylenediamine Chemical Properties,Usage,Production

Chemical Properties

Colorless to slightly yellow liquid

Uses

N,N,N',N'-Tetramethylethylenediamine is used as polymerization accelerator in gel electrophoresis, solvent and oxidizing reagent. It is also used for the separation of proteins or nucleic acids. Further, it is employed as a ligand for metal ions like zinc and copper. It is actively involved in the formation of anionic organometallic complex.

Definition

ChEBI: N,N,N',N'-tetramethylethylenediamine is an ethylenediamine derivative in which each nitrogen carries two methyl substituents. It is widely employed both as a ligand for metal ions and as a catalyst in organic polymerisation. It has a role as a chelator and a catalyst.

General Description

1,2-di-(dimethylamino)ethane appears as a water-white colored liquid with a fishlike odor. Flash point 68 °F. Less dense than water. Vapors heavier than air. Used to make other chemicals.

Air & Water Reactions

Highly flammable. Slightly soluble in water. Sensitive to heat and may be sensitive to air .

Reactivity Profile

N,N,N',N'-Tetramethylethylenediamine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Health Hazard

May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Safety Profile

Moderately toxic by ingestion. Mddly toxic by slun contact. A skin and severe eye irritant. Flammable when exposed to heat or flame; can react with oxidizing materials. When heated to decomposition it emits toxic fumes of NOx. See also MINES.

Purification Methods

Dry TMEDA partially with molecular sieves (Linde type 4A), then distil it in a vacuum from butyl lithium. This treatment removes all traces of primary and secondary amines and water. [Hay et al. J Chem Soc, Faraday Trans 1 68 1 1972.] Or dry it with KOH pellets, reflux for 2hours with one-sixth its weight of n-butyric anhydride (to remove primary and secondary amines) and fractionally distil it. Reflux it with fresh KOH, and distil it under nitrogen. [Cram & Wilson J Am Chem Soc 85 1245 1963.] It was also distilled from Na. Store it sealed under N2. The dipicrate has m 263o(dec). [Beilstein 4 H 250, 4 I 415, 4 II 690, 4 III 512, 4 IV 1172.]