5-AMINO-2-CHLOROPYRIDINE-4-CARBOXYLIC ACID

Product Name: 5-AMINO-2-CHLOROPYRIDINE-4-CARBOXYLIC ACID
CAS No.: 58483-95-7
Chemical Name: 5-AMINO-2-CHLOROPYRIDINE-4-CARBOXYLIC ACID
Synonyms: 5-amino-2-chloroisonicotinic acid;5-Amino-2-chloroisonicotinic;3-amino-6-chloroisonicotinicacid;2-chloro-5-amino-isonicotinic acid;5-Amino-2-chloropyridine-4-carboxylicaci;5-Amino-2-chloropyridin-4-carboxylic acid;5-Amino-2-chloro-4-pyridinecarboxylic acid;5-AMINO-2-CHLOROPYRIDINE-4-CARBOXYLIC ACID;5-Amino-2-Chloroisonicotinic Acid(WXC01548);4-Pyridinecarboxylic acid, 5-amino-2-chloro-
CBNumber: CB8103778
Molecular Formula: C6H5ClN2O2
Formula Weight: 172.57
MOL File: 58483-95-7.mol

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5-AMINO-2-CHLOROPYRIDINE-4-CARBOXYLIC ACID Property

Boiling point:: 514.4±50.0 °C(Predicted)
Density: 1.577±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 3.74±0.10(Predicted)
Appearance: Off-white to yellow Solid
InChI: InChI=1S/C6H5ClN2O2/c7-5-1-3(6(10)11)4(8)2-9-5/h1-2H,8H2,(H,10,11)
InChIKey: WCZUTMZMEAPPIX-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=C(N)C(C(O)=O)=C1

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Safety

Risk Statements: 36/37/38
Safety Statements: 22-26-36/37/39
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: A603220
Product name: 3-Amino-6-chloroisonicotinicAcid
Packaging: 250mg
Price: $145
Updated: 2021/12/16

TRC

Product number: A603220
Product name: 3-Amino-6-chloroisonicotinicAcid
Packaging: 2.5g
Price: $1175
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H21-5-Y0
Product name: 5-Amino-2-chloroisonicotinic acid
Packaging: 25g
Price: $493
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK103214
Product name: 5-Amino-2-chloropyridine-4-carboxylicacid
Purity: 97%
Packaging: 1g
Price: $568
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA57323
Product name: 5-Amino-2-chloropyridine-4-carboxylic acid
Packaging: 50g
Price: $600
Updated: 2021/12/16

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5-AMINO-2-CHLOROPYRIDINE-4-CARBOXYLIC ACID Chemical Properties,Usage,Production

Chemical Properties

Brown powder

Uses

3-Amino-6-chloroisonicotinic Acid is a useful synthetic intermediate. It can be used to prepare inhibitors of the EGFr and c-erbB-2. It can also be used to synthesise modulators of GHSr-1a for the treatment of type II diabetes and obesity.

Synthesis

171178-46-4

58483-95-7

The general procedure for the synthesis of 5-amino-2-chloropyridine-4-carboxylic acid from 5-tert-butoxycarbonylamino-2-chloropyridine-4-carboxylic acid is as follows: 5-[N-(tert-butoxycarbonyl)amino]-2-chloropyridine-4-carboxylic acid (1.91 g, 7 mmol) was suspended in dichloromethane (200 mL), and trifluoroacetic acid was added slowly dropwise with stirring until the solution became homogeneous (about 5%) 12 mL). The reaction mixture was stirred overnight at room temperature. Subsequently, the reaction mixture was extracted with dilute aqueous ammonia solution and the aqueous phase was acidified with dilute hydrochloric acid to precipitate 5-amino-2-chloropyridine-4-carboxylic acid precipitate (1.05 g, 87% yield). The product was characterized by nuclear magnetic resonance hydrogen spectroscopy (DMSO-d6): δ 9.01 (2H, multiple peaks), 8.03 (1H, single peak), 7.48 (1H, single peak).

References

[1] Journal of the Chemical Society - Perkin Transactions 1, 1996, # 18, p. 2221 - 2226
[2] Patent: US5654307, 1997, A
[3] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 11, p. 1401 - 1405
[4] Patent: WO2005/16926, 2005, A1. Location in patent: Page/Page column 115-116; 123
[5] ACS Medicinal Chemistry Letters, 2018, vol. 9, # 3, p. 256 - 261

5-AMINO-2-CHLOROPYRIDINE-4-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

5-Amino-2-chloropyridine Hexane Ammonium hydroxide N,N,N',N'-Tetramethylethylenediamine Di-tert-butyl dicarbonate Trifluoroacetic acid Triethylamine Carbon dioxide 1,4-Dioxane Diethyl ether Hydrochloric acid Dichloromethane n-Butyllithium

Preparation Products

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5-AMINO-2-CHLOROPYRIDINE-4-CARBOXYLIC ACID Suppliers

China 158 Germany 1 India 2 United Kingdom 4 United States 18 Global 183

Shandong Yizhi Medical Technology Co., LTD

Tel: 13287715206 15508629772
Email: 2786175817@qq.com
Country: China
ProdList: 65
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 15883
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

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View Lastest Price from 5-AMINO-2-CHLOROPYRIDINE-4-CARBOXYLIC ACID manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 5-AMINO-2-CHLOROPYRIDINE-4-CARBOXYLIC ACID 58483-95-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-14

Dideu Industries Group Limited

Product: 5-AMINO-2-CHLOROPYRIDINE-4-CARBOXYLIC ACID 58483-95-7
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-09-03

Career Henan Chemical Co

Product: 5-AMINO-2-CHLOROPYRIDINE-4-CARBOXYLIC ACID 58483-95-7
Price: US $8.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10tons
Release date: 2018-12-24

58483-95-7, 5-AMINO-2-CHLOROPYRIDINE-4-CARBOXYLIC ACIDRelated Search:

3-Amino-2,6-dichloro-isonicotinic acid ethyl ester 5-AMINO-2-CHLOROPYRIDINE-4-CARBOXYLIC ACID 5-AMINO-2-CHLOROPYRIDINE-3-CARBOXYLIC ACID 3-AMINO-2-CHLOROPYRIDINE-4-CARBOXYLIC ACID METHYL ESTER 5-TERT-BUTOXYCARBONYLAMINO-2-CHLORO-NICOTINIC ACID 3-Amino-6-chloropyridine-2-carboxylic acid 2-Amino-5-chloropyridine-3-carboxylic acid 5-Amino-2-chloropyridine 2-Chloropyridine 5-[(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROISONICOTINIC ACID ETHYL 2-CHLORO-3-CYANO-6-METHYL-5-NITROPYRIDINE-4-CARBOXYLATE 2-amino-6-chloropyridine-4-carboxylic acid 3-amino-5-chloropyridine-2-carboxylic acid 5-Boc-amino-2-chloropyridine-4-carboxylic acid ,97%,5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE-4-CARBOXYLIC ACID RARECHEM AL BW 1166 6-({2-[bis(propan-2-yl)amino]ethyl}amino)-5-chloropyridine-3-carboxylic acid 6-[(1-{bicyclo[2.2.1]heptan-2-yl}ethyl)amino]-3-chloropyridine-2-carboxylic acid 6-[(4-bromo-3-methylphenyl)amino]-3-chloropyridine-2-carboxylic acid

5-AMINO-2-CHLOROPYRIDINE-4-CARBOXYLIC ACID

5-amino-2-chloroisonicotinic acid

5-Amino-2-chloropyridine-4-carboxylic acid ,97%

3-amino-6-chloroisonicotinicacid

5-Amino-2-chloro-4-pyridinecarboxylic acid

5-Amino-2-chloropyridine-4-carboxylic acid, 5-Amino-4-carboxy-2-chloropyridine

5-Amino-2-Chloroisonicotinic Acid(WXC01548)

5-Amino-2-chloroisonicotinic

4-Pyridinecarboxylic acid, 5-amino-2-chloro-

5-Amino-2-chloropyridine-4-carboxylicaci

5-AMINO-2-CHLOROPYRIDINE-4-CARBOXYLIC ACID ISO 9001：2015 REACH

2-chloro-5-amino-isonicotinic acid

5-Amino-2-chloropyridin-4-carboxylic acid

58483-95-7

Heterocycle-Pyridine series

Pyridine

Carboxylic Acids

Pyridines

Carboxylic Acids