5-[(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROISONICOTINIC ACID

Product Name: 5-[(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROISONICOTINIC ACID
CAS No.: 171178-46-4
Chemical Name: 5-[(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROISONICOTINIC ACID
Synonyms: 5-(Boc-amino)-2-chloroisonicotinic Acid;5-Boc-amino-2-chloropyridine-4-carboxylic;5-BOC-AMINO-2-CHLOROPYRIDINE-4-CARBOXYLIC ACID;5-Amino-2-chloroisonicotinic acid, 5-BOC protected;5-[(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROISONICOTINIC ACID;4-Pyridinecarboxylic acid, 2-chloro-5-[[(1,1-dimethylethoxy)...;5-[(tert-Butoxycarbonyl)amino]-2-chloropyridine-4-carboxylic acid;2-chloro-5-[(2-methylpropan-2-yl)oxycarbonylamino]pyridine-4-carboxylicaci;2-chloro-5-[(2-methylpropan-2-yl)oxycarbonylamino]pyridine-4-carboxylic acid;5-[(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROISONICOTINIC ACID ISO 9001：2015 REACH
CBNumber: CB31517548
Molecular Formula: C11H13ClN2O4
Formula Weight: 272.68
MOL File: 171178-46-4.mol

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5-[(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROISONICOTINIC ACID Property

Boiling point:: 420.6±45.0 °C(Predicted)
Density: 1.390±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 2.52±0.36(Predicted)
Appearance: White to off-white Solid

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Safety

Risk Statements: 20/21/22
Safety Statements: 36/37-24/25
HazardClass: IRRITANT
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

SynQuest Laboratories

Product number: 4H58-5-59
Product name: 5-Amino-2-chloroisonicotinic acid, 5-Boc protected
Packaging: 250mg
Price: $149
Updated: 2021/12/16

Matrix Scientific

Product number: 059246
Product name: 5-tert-Butoxycarbonylamino-2-chloro-isonicotinic acid
Purity: 95+%
Packaging: 500mg
Price: $230
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK240283
Product name: 5-Boc-amino-2-chloropyridine-4-carboxylicacid
Purity: 97%
Packaging: 1g
Price: $241
Updated: 2021/12/16

Matrix Scientific

Product number: 059246
Product name: 5-tert-Butoxycarbonylamino-2-chloro-isonicotinic acid
Purity: 95+%
Packaging: 1g
Price: $355
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H58-5-59
Product name: 5-Amino-2-chloroisonicotinic acid, 5-Boc protected
Packaging: 1g
Price: $395
Updated: 2021/12/16

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5-[(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROISONICOTINIC ACID Chemical Properties,Usage,Production

Chemical Properties

Off-white solid

Synthesis

124-38-9

171178-45-3

171178-46-4

Step (c): Synthesis of 5-tert-butoxycarbonylamino-2-chloropyridine-4-carboxylic acid Tert-butyl 6-chloropyridin-3-ylcarbamate (800 mL ether suspension) was mixed with TMEDA and cooled to -75 °C. A hexane solution of 1.6 M n-butyllithium was slowly added dropwise at a temperature below -65 °C. After the dropwise addition was completed, the reaction mixture was warmed to -15°C to -10°C and stirred in this temperature range for 2 hours. Subsequently, the mixture was cooled again to -75°C and dry carbon dioxide gas was passed into it for 3 hours. Afterwards, the reaction mixture was allowed to slowly warm up to room temperature overnight, during which time carbon dioxide was continuously passed through. Upon completion of the reaction, the reaction was carefully quenched with 20% aqueous ammonium hydroxide solution (1.8 L) and the aqueous phase was extracted with ether. The reaction was then acidified to pH 5 with 50% aqueous hydrochloric acid, the resulting solid was collected by filtration, washed with water and dried to afford 33.07 g (69.3% yield) of 5-tert-butoxycarbonylamino-2-chloropyridine-4-carboxylic acid as a light yellow solid. 1H NMR (400 MHz, DMSO-d6) δ ppm: 1.5 (s, 9H), 7.7 (s, 1H), 9.1 (s, 1H), 10.0 (s, 1H). MS (APCI) m/z: [M + 1]+ = 273.1.

References

[1] Patent: WO2005/16926, 2005, A1. Location in patent: Page/Page column 114-115
[2] ACS Medicinal Chemistry Letters, 2018, vol. 9, # 3, p. 256 - 261
[3] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 11, p. 1401 - 1405
[4] Patent: WO2005/16926, 2005, A1. Location in patent: Page/Page column 122-123
[5] Journal of the Chemical Society - Perkin Transactions 1, 1996, # 18, p. 2221 - 2226

5-[(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROISONICOTINIC ACID Preparation Products And Raw materials

Raw materials

5-Amino-2-chloropyridine Hexane N,N,N',N'-Tetramethylethylenediamine Di-tert-butyl dicarbonate Triethylamine Carbon dioxide Diethyl ether Hydrochloric acid Dichloromethane n-Butyllithium

Preparation Products

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5-[(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROISONICOTINIC ACID Suppliers

China 38 India 1 United Kingdom 2 United States 7 Global 48

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View Lastest Price from 5-[(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROISONICOTINIC ACID manufacturers

Dideu Industries Group Limited

Product: 5-[(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROISONICOTINIC ACID 171178-46-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-09-06

171178-46-4, 5-[(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROISONICOTINIC ACIDRelated Search:

5-AMINO-2-CHLOROPYRIDINE-4-CARBOXYLIC ACID 3-TERT-BUTOXYCARBONYLAMINO-ISONICOTINIC ACID 3-(BOC-AMINO)-4-PICOLINE 5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE 3-METHOXYCARBONYLAMINO-4-METHYLPYRIDINE 5-[(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROISONICOTINIC ACID TERT-BUTYL 4-FORMYLPYRIDIN-3-YLCARBAMATE

5-[(tert-Butoxycarbonyl)amino]-2-chloropyridine-4-carboxylic acid

5-Amino-2-chloroisonicotinic acid, 5-BOC protected

5-[(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROISONICOTINIC ACID

5-BOC-AMINO-2-CHLOROPYRIDINE-4-CARBOXYLIC ACID

4-Pyridinecarboxylic acid, 2-chloro-5-[[(1,1-dimethylethoxy)carbonyl]amino]-

5-Boc-amino-2-chloropyridine-4-carboxylic

2-chloro-5-[(2-methylpropan-2-yl)oxycarbonylamino]pyridine-4-carboxylicaci

5-[(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROISONICOTINIC ACID ISO 9001：2015 REACH

4-Pyridinecarboxylic acid, 2-chloro-5-[[(1,1-dimethylethoxy)...

5-(Boc-amino)-2-chloroisonicotinic Acid

2-chloro-5-[(2-methylpropan-2-yl)oxycarbonylamino]pyridine-4-carboxylic acid

171178-46-4

Carboxylic Acids

Pyridines