TERT-BUTYL 4-FORMYLPYRIDIN-3-YLCARBAMATE

Product Name: TERT-BUTYL 4-FORMYLPYRIDIN-3-YLCARBAMATE
CAS No.: 116026-95-0
Chemical Name: TERT-BUTYL 4-FORMYLPYRIDIN-3-YLCARBAMATE
Synonyms: N-Boc-3-amino;TERT-BUTYL 4-FORMYLP;N-Boc-3-amino-4-formylpyridine;t-Butyl 4-formylpyridin-3-ylcarbamate;3-(Boc-amino)pyridine-4-carboxaldehyde;TERT-BUTYL 4-FORMYLPYRIDIN-3-YLCARBAMAT;N-BOC-3-AMINO-4-PYRIDINE CARBOXYALDEHYDE;TERT-BUTYL 4-FORMYLPYRIDIN-3-YLCARBAMATE;N-Boc-3-amino-4-pyridine carboxzyaldehyde;3-Aminoisonicotinaldehyde, 3-BOC protected
CBNumber: CB7118153
Molecular Formula: C11H14N2O3
Formula Weight: 222.24
MOL File: 116026-95-0.mol

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TERT-BUTYL 4-FORMYLPYRIDIN-3-YLCARBAMATE Property

Melting point:: 52-53 °C
Boiling point:: 310.0±27.0 °C(Predicted)
Density: 1.212±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 12.42±0.70(Predicted)
Appearance: White to yellow Solid
InChI: InChI=1S/C11H14N2O3/c1-11(2,3)16-10(15)13-9-6-12-5-4-8(9)7-14/h4-7H,1-3H3,(H,13,15)
InChIKey: YLKONQAWPOHLPX-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)NC1=C(C=O)C=CN=C1

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P363Wash contaminated clothing before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

TRC

Product number: B701855
Product name: t-Butyl4-Formylpyridin-3-ylcarbamate
Packaging: 100mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB50917
Product name: (tert-Butyl-4-formylpyridin-3-yl)carbamate
Packaging: 500mg
Price: $120
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB50917
Product name: (tert-Butyl-4-formylpyridin-3-yl)carbamate
Packaging: 250mg
Price: $75
Updated: 2021/12/16

Apolloscientific

Product number: OR6174
Product name: 3-Aminoisonicotinaldehyde, 3-BOC protected
Packaging: 1g
Price: $192
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-B9
Product name: 3-Aminopyridine-4-carboxaldehyde, 3-Boc protected
Purity: 95%
Packaging: 1g
Price: $228
Updated: 2021/12/16

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TERT-BUTYL 4-FORMYLPYRIDIN-3-YLCARBAMATE Chemical Properties,Usage,Production

Synthesis

2591-86-8

116026-95-0

The general procedure for the synthesis of tert-butyl (4-formylpyridin-3-yl) carbamate from N-formylpiperidine was as follows: tert-butylpyridin-3-yl carbamate (17.7 g, 91.1 mmol) was dissolved in THF (300 mL) and the solution was cooled to -78 °C. A pentane solution of 1.70 M tert-butyllithium (129 mL) was slowly added with stirring. After addition, the reaction mixture was continued to be stirred at -78 °C for 15 minutes, followed by warming to -20 °C and stirring for 1.5 hours. Keeping the temperature below -15 °C, 1-piperidinecarboxaldehyde (30.4 mL, 0.273 mol) was added dropwise to the reaction mixture. After the dropwise addition was completed, the reaction mixture was brought to room temperature and stirred overnight. Upon completion of the reaction, the mixture was cooled to 0 °C and the pH was adjusted to 2 by slow addition of 1 M HCl solution.Subsequently, solid Na2CO3 was added to adjust the pH to 7. The reaction mixture was extracted three times with ethyl acetate and the organic phases were combined. The organic phase was washed sequentially with water (three times) and saturated saline. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to remove the solvent. The residue was purified by silica gel column chromatography (eluent: 50% ethyl acetate/hexane) to afford the target product (4-formylpyridin-3-yl)carbamic acid tert-butyl ester as a yellow solid (12.2 g, 60% yield).LCMS analysis: m/z = 223.1 for C11H15N2O3 ([M+H]+).

References

[1] Patent: WO2007/38215, 2007, A1. Location in patent: Page/Page column 104-105

TERT-BUTYL 4-FORMYLPYRIDIN-3-YLCARBAMATE Preparation Products And Raw materials

Raw materials

tert-Butyllithium Di-tert-butyl dicarbonate 3-Aminopyridine Chloroform Pentane Tetrahydrofuran Ethyl acetate Methanol Sodium bis(trimethylsilyl)amide Magnesium sulfate N-Formylpiperidine

Preparation Products

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TERT-BUTYL 4-FORMYLPYRIDIN-3-YLCARBAMATE Suppliers

China 79 Germany 1 India 1 United Kingdom 3 United States 21 Global 105

Hefei Mokai Pharmaceutical Technology Co., Ltd

Tel: 18130062233
Email: 3362556465@qq.com
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J & K SCIENTIFIC LTD.

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Capot Chemical Co., Ltd

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Shanghai Chemical Pharm-Intermediate Tech.Co., Ltd.

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Adamas Reagent, Ltd.

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Shanghai Hanhong Scientific Co.,Ltd.

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Shanghai Ennopharm Co., Ltd.

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NovoChemy Ltd.

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Country: Germany
ProdList: 6328
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View Lastest Price from TERT-BUTYL 4-FORMYLPYRIDIN-3-YLCARBAMATE manufacturers

Dideu Industries Group Limited

Product: TERT-BUTYL 4-FORMYLPYRIDIN-3-YLCARBAMATE 116026-95-0
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-28

Career Henan Chemical Co

Product: 4-methyl ester 2,2-dimethyl-Butanedioic acid 116026-95-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 85.0-99.8%
Supply Ability: 20 tons
Release date: 2019-12-25

116026-95-0, TERT-BUTYL 4-FORMYLPYRIDIN-3-YLCARBAMATERelated Search:

TERT-BUTYL 2-FORMYLPYRIDIN-3-YLCARBAMATE TERT-BUTYL 3-FORMYLPYRIDIN-4-YLCARBAMATE TERT-BUTYL 3-FORMYLPYRIDIN-2-YLCARBAMATE TERT-BUTYL 4-FORMYLPYRIDIN-3-YLCARBAMATE TERT-BUTYL 4-FORMYL-5-METHOXYPYRIDIN-3-YLCARBAMATE 5-TERT-BUTOXYCARBONYLAMINO-2-FLUOROISONICOTINIC ACID [6-FLUORO-4-(3-NITRILOPROPIONYL)PYRIDIN-3-YL]CARBAMIC ACID TERT-BUTYL ESTER 5-[(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROISONICOTINIC ACID methyl 5-(tert-butoxycarbonylamino)-2-fluoroisonicotinate 3-(TERT-BUTOXYCARBONYLAMINO)-5-METHOXYISONICOTINIC ACID 2-METHOXY-3-(BOC-AMINO)-4-TRIFLUORO-ACETYLPYRIDINE 5-(TERT-BUTOXYCARBONYLAMINO)-2-METHOXYPYRIDINE-4-CARBOXYLIC ACID 3-TERT-BUTOXYCARBONYLAMINO-ISONICOTINIC ACID

3-AMINOPYRIDINE-4-CARBOXALDEHYDE, 3-BOC PROTECTED

(4-FORMYL-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER

N-Boc-3-amino-4-pyridine carboxzyaldehyde

3-Aminopyridine-4-carboxaldehyde, 3-BOC protected 95%

N-Boc-3-amino-4-formylpyridine

t-Butyl 4-formylpyridin-3-ylcarbamate

Carbamic acid, N-(4-formyl-3-pyridinyl)-, 1,1-dimethylethyl ester

3-Aminoisonicotinaldehyde, 3-BOC protected 95%

tert-Butyl (4-formylpyridin-3-yl)carbamate, 3-[(tert-Butoxycarbonyl)amino]-4-formylpyridine, 3-Aminopyridine-4-carboxaldehyde, 3-BOC protected

3-Aminoisonicotinaldehyde,3-BOCprotected95%

tert-butyl N-(4-formylpyridin-3-yl)carbamate

N-BOC-3-AMINO-4-PYRIDINE CARBOXYALDEHYDE

TERT-BUTYL 4-FORMYLPYRIDIN-3-YLCARBAMATE

N-Boc-3-amino

TERT-BUTYL 4-FORMYLP

3-Aminoisonicotinaldehyde, 3-BOC protected

ert-butylN-(4-formylpyridin-3-yl)carbamate

1,1-Dimethylethyl N-(4-formyl-3-pyridinyl)carbamate

TERT-BUTYL 4-FORMYLPYRIDIN-3-YLCARBAMAT

3-(Boc-amino)pyridine-4-carboxaldehyde

116026-95-0

Building Blocks

Pyridine

Aldehydes

Pyridines