(2-FORMYL-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER

Product Name: (2-FORMYL-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER
CAS No.: 116026-99-4
Chemical Name: (2-FORMYL-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER
Synonyms: Boc - 3 - aMinopicolinaldehyde;TERT-BUTYL 2-FORMYLPYRIDIN-3-YLCARBAMATE;tert-butyl N-(2-formylpyridin-3-yl)carbamate;(tert-butoxy)-N-(2-forMyl(2-pyridyl)-carboxaMide;3-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-2-CARBOXALDEHYDE;3-TERT-BUTYROXCARBONYLAMINE-PYRIDINE-2-CARBOXALDEHYDE;N-(5-formyl-2-pyridinyl)carbamic acid tert-butyl ester;(2-FORMYL-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER;(2-Formylpyridin-3-yl)-carbamic acid tert-butyl ester ,97%;Carbamic acid, N-(2-formyl-3-pyridinyl)-, 1,1-dimethylethyl ester
CBNumber: CB6203258
Molecular Formula: C11H14N2O3
Formula Weight: 222.24
MOL File: 116026-99-4.mol

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(2-FORMYL-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER Property

Melting point:: 79.4-79.6°C
Boiling point:: 295.0±25.0 °C(Predicted)
Density: 1.212±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 12.42±0.70(Predicted)
color: Light Yellow
InChI: InChI=1S/C11H14N2O3/c1-11(2,3)16-10(15)13-8-5-4-6-12-9(8)7-14/h4-7H,1-3H3,(H,13,15)
InChIKey: AHTZIHDCJWVLKK-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)NC1=CC=CN=C1C=O

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-36-43-36/37/38
Safety Statements: 26-36/37-36
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: ADE000286
Product name: (2-Formyl-pyridin-3-yl)-carbamic acid tert-butyl ester
Purity: Aldrich
Packaging: 1g
Price: $259
Updated: 2025/07/31

TRC

Product number: B116925
Product name: tert-Butyl(2-Formylpyridin-3-yl)carbamate
Packaging: 500mg
Price: $285
Updated: 2021/12/16

Matrix Scientific

Product number: 016071
Product name: (2-Formyl-pyridin-3-yl)-carbamic acidtert-butyl ester
Packaging: 500mg
Price: $100
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK253788
Product name: (2-Formyl-pyridin-3-yl)-carbamic acid tert-butyl ester
Purity: 97%
Packaging: 500mg
Price: $258
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK253788
Product name: (2-Formyl-pyridin-3-yl)-carbamic acid tert-butyl ester
Purity: 97%
Packaging: 1g
Price: $468
Updated: 2021/12/16

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(2-FORMYL-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production

Chemical Properties

White to off-white solid

Synthesis

2591-86-8

116026-98-3

116026-99-4

Step 2: Synthesis of tert-butyl (2-formylpyridin-3-yl)carbamate (10b) To a solution of compound 10a (2.9 g, 10.7 mmol) in tetrahydrofuran (THF, 30 mL) was slowly added n-butyllithium (n-BuLi, 2.5 M, 8.5 mL, 21.4 mmol) at -78 °C and protected by nitrogen (N2). The reaction mixture was stirred continuously at this temperature for 1 hour. Subsequently, N-formylpiperidine (1.3 mL, 11.8 mmol) was added under fast stirring conditions. The reaction system was warmed up to 0 °C and stirring was continued for 1 hour. Upon completion of the reaction, it was partitioned with 1.5 M hydrochloric acid (HCl) solution. The pH of the aqueous layer was adjusted to 7 by addition of solid sodium carbonate (Na2CO3).The aqueous layer was extracted twice with ethyl acetate (EA), the organic layers were combined and dried with anhydrous sodium sulfate (Na2SO4). After concentration under reduced pressure, purification by column chromatography (CC, petroleum ether/ethyl acetate = 3/1) afforded the target compound 10b (1.5 g, 65% yield) as a white solid.

References

[1] Journal of Medicinal Chemistry, 1988, vol. 31, # 11, p. 2136 - 2145
[2] Journal of Medicinal Chemistry, 2009, vol. 52, # 16, p. 5032 - 5043
[3] Patent: WO2013/64231, 2013, A1. Location in patent: Page/Page column 51

(2-FORMYL-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Hexane Diphenylphosphoryl azide tert-Butanol Triethylamine Chloroform Tetrahydrofuran Ethyl acetate Potassium permanganate 2-Bromo-3-methylpyridine n-Butyllithium

Preparation Products

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(2-FORMYL-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER Suppliers

China 61 Germany 2 India 1 United Kingdom 2 United States 22 Global 88

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View Lastest Price from (2-FORMYL-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER manufacturers

Career Henan Chemical Co

Product: (2-FORMYL-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER 116026-99-4
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200KG
Release date: 2020-01-09

116026-99-4, (2-FORMYL-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTERRelated Search:

(4-FORMYL-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER (5-Formyl-pyridin-2-yl)-carbamic acid tert-butyl ester (3-FORMYL-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER (3-FORMYL-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER 3-AMINO-PYRIDINE-2-CARBALDEHYDE 3-(BOC-AMINO)PYRIDINE 3-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-2-CARBOXYLIC ACID (2-FORMYL-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER

3-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-2-CARBOXALDEHYDE

3-TERT-BUTYROXCARBONYLAMINE-PYRIDINE-2-CARBOXALDEHYDE

(2-FORMYL-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER

TERT-BUTYL 2-FORMYLPYRIDIN-3-YLCARBAMATE

(2-Formylpyridin-3-yl)-carbamic acid tert-butyl ester ,97%

Boc - 3 - aMinopicolinaldehyde

(tert-butoxy)-N-(2-forMyl(2-pyridyl)-carboxaMide

Carbamic acid, N-(2-formyl-3-pyridinyl)-, 1,1-dimethylethyl ester

tert-butyl N-(2-formylpyridin-3-yl)carbamate

N-(5-formyl-2-pyridinyl)carbamic acid tert-butyl ester

116026-99-4

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