2-N-Boc-amino-3-formylpyridine

Uses

Product Name: 2-N-Boc-amino-3-formylpyridine
CAS No.: 116026-94-9
Chemical Name: 2-N-Boc-amino-3-formylpyridine
Synonyms: margin: 0px;padding: 0px;color: rgb(255, 0, 0);">-3-pyridinecarboxaldehyde;2-BOC-AMINO-3-FORMYLPYRIDINE;2-N-BOC-AMINO-3-FORMYLPYRIDINE;REF DUPL: 2-N-Boc-amino-3-formylpyridine;TERT-BUTYL 3-FORMYLPYRIDIN-2-YLCARBAMATE;ert-butylN-(3-formylpyridin-2-yl)carbamate;tert-butyl N-(3-forMylpyridin-2-yl)carbaMate
CBNumber: CB4337104
Molecular Formula: C11H14N2O3
Formula Weight: 222.24
MOL File: 116026-94-9.mol

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2-N-Boc-amino-3-formylpyridine Property

Melting point:: 109-111 °C
Boiling point:: 310 °C
Density: 1.212
Flash point:: 141 °C
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 12.05±0.70(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B619105
Product name: 2-N-Boc-amino-3-formylpyridine
Packaging: 1g
Price: $380
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 36062
Product name: tert-Butyl(3-formylpyridin-2-yl)carbamate
Purity: 95+%
Packaging: 1g
Price: $480
Updated: 2021/12/16

Chemenu

Product number: CM105385
Product name: tert-Butyl(3-formylpyridin-2-yl)carbamate
Purity: 98%
Packaging: 5g
Price: $286
Updated: 2021/12/16

Crysdot

Product number: CD11343609
Product name: tert-Butyl(3-formylpyridin-2-yl)carbamate
Purity: 98%
Packaging: 5g
Price: $303
Updated: 2021/12/16

Alichem

Product number: 116026949
Product name: tert-Butyl(3-formylpyridin-2-yl)carbamate
Packaging: 5g
Price: $339.66
Updated: 2021/12/16

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2-N-Boc-amino-3-formylpyridine Chemical Properties,Usage,Production

Uses

2-Boc-amino-3-pyridinecarboxaldehyde can be used as a pharmaceutical synthesis intermediate. It can be prepared by reacting 2-aminopyridine with (Boc)2O protecting group to prepare intermediate 2-(tert-butyloxycarbonylamino)pyridine, which is then reacted with tert-butyllithium and DMF to obtain the final product.

Synthesis

38427-94-0

68-12-2

116026-94-9

Step 2: Synthesis of tert-butyl 3-formylpyridin-2-ylcarbamate (9b) To a solution of compound 9a (14.0 g, 72 mmol) in anhydrous ether (500 mL) at -78 °C and under nitrogen protection, tert-butyllithium (1.7 M, 106 mL, 180 mmol) was slowly added. The reaction mixture was slowly warmed to 0 °C and stirred at this temperature for 1 hour. Subsequently, anhydrous N,N-dimethylformamide (8.0 mL, 103 mmol) was added rapidly under vigorous stirring. The reaction mixture was continued to be stirred at 0 °C for 10 min and then quenched with a half-saturated aqueous ammonium chloride solution. The aqueous layer was separated and extracted twice with ethyl acetate (EA). The organic layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by column chromatography (eluent: petroleum ether/ethyl acetate = 3/1) to afford the target product 9b (8.0 g, 52% yield) as a white solid.

References

[1] Patent: WO2013/64231, 2013, A1. Location in patent: Page/Page column 45
[2] Heterocyclic Communications, 2011, vol. 17, # 1-2, p. 21 - 23

2-N-Boc-amino-3-formylpyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-N-Boc-amino-3-formylpyridine Suppliers

China 55 Germany 2 India 2 United States 15 Global 74

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Hotechem Shanghai Co., Ltd.,

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SanoChem (Chengdu) Tech. Co., Ltd.

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View Lastest Price from 2-N-Boc-amino-3-formylpyridine manufacturers

Dideu Industries Group Limited

Product: 2-N-Boc-amino-3-formylpyridine 116026-94-9
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-27

116026-94-9, 2-N-Boc-amino-3-formylpyridineRelated Search:

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Carbamic acid, N-(3-formyl-2-pyridinyl)-, 1,1-dimethylethyl ester

tert-butyl N-(3-forMylpyridin-2-yl)carbaMate

2-N-BOC-AMINO-3-FORMYLPYRIDINE

2-BOC-AMINO-3-FORMYLPYRIDINE

(3-FORMYL-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER

TERT-BUTYL 3-FORMYLPYRIDIN-2-YLCARBAMATE

REF DUPL: 2-N-Boc-amino-3-formylpyridine

ert-butylN-(3-formylpyridin-2-yl)carbamate

2-N-Boc-amino-3-formylpyridine ISO 9001：2015 REACH

2-<N-(tert-butyloxycarbonyl)amino>-3-pyridinecarboxaldehyde

">-3-pyridinecarboxaldehyde

2-<n-(tert-butyloxycarbonyl)amino style="margin: 0px

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1,1-Dimethylethyl N-(3-formyl-2-pyridinyl)carbamate

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116026-94-9

Pyridines