Uses
ChemicalBook > CAS DataBase List > 2-N-Boc-amino-3-formylpyridine

2-N-Boc-amino-3-formylpyridine

Uses
Product Name
2-N-Boc-amino-3-formylpyridine
CAS No.
116026-94-9
Chemical Name
2-N-Boc-amino-3-formylpyridine
Synonyms
margin: 0px;padding: 0px;color: rgb(255, 0, 0);">-3-pyridinecarboxaldehyde;2-BOC-AMINO-3-FORMYLPYRIDINE;2-N-BOC-AMINO-3-FORMYLPYRIDINE;REF DUPL: 2-N-Boc-amino-3-formylpyridine;TERT-BUTYL 3-FORMYLPYRIDIN-2-YLCARBAMATE;ert-butylN-(3-formylpyridin-2-yl)carbamate;tert-butyl N-(3-forMylpyridin-2-yl)carbaMate
CBNumber
CB4337104
Molecular Formula
C11H14N2O3
Formula Weight
222.24
MOL File
116026-94-9.mol
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2-N-Boc-amino-3-formylpyridine Property

Melting point:
109-111 °C
Boiling point:
310 °C
Density 
1.212
Flash point:
141 °C
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
12.05±0.70(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B619105
Product name
2-N-Boc-amino-3-formylpyridine
Packaging
1g
Price
$380
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
36062
Product name
tert-Butyl(3-formylpyridin-2-yl)carbamate
Purity
95+%
Packaging
1g
Price
$480
Updated
2021/12/16
Crysdot
Product number
CD11343609
Product name
tert-Butyl(3-formylpyridin-2-yl)carbamate
Purity
98%
Packaging
10g
Price
$495
Updated
2021/12/16
Alichem
Product number
116026949
Product name
tert-Butyl(3-formylpyridin-2-yl)carbamate
Packaging
10g
Price
$525
Updated
2021/12/16
Chemenu
Product number
CM105385
Product name
tert-Butyl(3-formylpyridin-2-yl)carbamate
Purity
98%
Packaging
10g
Price
$468
Updated
2021/12/16
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2-N-Boc-amino-3-formylpyridine Chemical Properties,Usage,Production

Uses

2-Boc-amino-3-pyridinecarboxaldehyde can be used as a pharmaceutical synthesis intermediate. It can be prepared by reacting 2-aminopyridine with (Boc)2O protecting group to prepare intermediate 2-(tert-butyloxycarbonylamino)pyridine, which is then reacted with tert-butyllithium and DMF to obtain the final product.

Synthesis

38427-94-0

68-12-2

116026-94-9

Step 2: Synthesis of tert-butyl 3-formylpyridin-2-ylcarbamate (9b) To a solution of compound 9a (14.0 g, 72 mmol) in anhydrous ether (500 mL) at -78 °C and under nitrogen protection, tert-butyllithium (1.7 M, 106 mL, 180 mmol) was slowly added. The reaction mixture was slowly warmed to 0 °C and stirred at this temperature for 1 hour. Subsequently, anhydrous N,N-dimethylformamide (8.0 mL, 103 mmol) was added rapidly under vigorous stirring. The reaction mixture was continued to be stirred at 0 °C for 10 min and then quenched with a half-saturated aqueous ammonium chloride solution. The aqueous layer was separated and extracted twice with ethyl acetate (EA). The organic layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by column chromatography (eluent: petroleum ether/ethyl acetate = 3/1) to afford the target product 9b (8.0 g, 52% yield) as a white solid.

References

[1] Patent: WO2013/64231, 2013, A1. Location in patent: Page/Page column 45
[2] Heterocyclic Communications, 2011, vol. 17, # 1-2, p. 21 - 23

2-N-Boc-amino-3-formylpyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-N-Boc-amino-3-formylpyridine Suppliers

China 55 Germany 2 India 2 United States 15 Global 74
chemcube
Tel
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Fax
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Email
sales@chemcube.eu
Country
Germany
ProdList
4083
Advantage
34
ABCR GmbH & CO. KG
Tel
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Fax
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Email
info@abcr.de
Country
Germany
ProdList
6831
Advantage
75
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View Lastest Price from 2-N-Boc-amino-3-formylpyridine manufacturers

Dideu Industries Group Limited
Product
2-N-Boc-amino-3-formylpyridine 116026-94-9
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-10-27

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