ChemicalBook > CAS DataBase List > 2-N-Boc-amino-3-formylpyridine
2-N-Boc-amino-3-formylpyridine
Uses- Product Name
- 2-N-Boc-amino-3-formylpyridine
- CAS No.
- 116026-94-9
- Chemical Name
- 2-N-Boc-amino-3-formylpyridine
- Synonyms
- margin: 0px;padding: 0px;color: rgb(255, 0, 0);">-3-pyridinecarboxaldehyde;2-BOC-AMINO-3-FORMYLPYRIDINE;2-N-BOC-AMINO-3-FORMYLPYRIDINE;REF DUPL: 2-N-Boc-amino-3-formylpyridine;TERT-BUTYL 3-FORMYLPYRIDIN-2-YLCARBAMATE;ert-butylN-(3-formylpyridin-2-yl)carbamate;tert-butyl N-(3-forMylpyridin-2-yl)carbaMate
- CBNumber
- CB4337104
- Molecular Formula
- C11H14N2O3
- Formula Weight
- 222.24
- MOL File
- 116026-94-9.mol
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2-N-Boc-amino-3-formylpyridine Property
- Melting point:
- 109-111 °C
- Boiling point:
- 310 °C
- Density
- 1.212
- Flash point:
- 141 °C
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 12.05±0.70(Predicted)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- B619105
- Product name
- 2-N-Boc-amino-3-formylpyridine
- Packaging
- 1g
- Price
- $380
- Updated
- 2021/12/16
Medical Isotopes, Inc.
- Product number
- 36062
- Product name
- tert-Butyl(3-formylpyridin-2-yl)carbamate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $480
- Updated
- 2021/12/16
Crysdot
- Product number
- CD11343609
- Product name
- tert-Butyl(3-formylpyridin-2-yl)carbamate
- Purity
- 98%
- Packaging
- 10g
- Price
- $495
- Updated
- 2021/12/16
Alichem
- Product number
- 116026949
- Product name
- tert-Butyl(3-formylpyridin-2-yl)carbamate
- Packaging
- 10g
- Price
- $525
- Updated
- 2021/12/16
Chemenu
- Product number
- CM105385
- Product name
- tert-Butyl(3-formylpyridin-2-yl)carbamate
- Purity
- 98%
- Packaging
- 10g
- Price
- $468
- Updated
- 2021/12/16
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2-N-Boc-amino-3-formylpyridine Chemical Properties,Usage,Production
Uses
2-Boc-amino-3-pyridinecarboxaldehyde can be used as a pharmaceutical synthesis intermediate. It can be prepared by reacting 2-aminopyridine with (Boc)2O protecting group to prepare intermediate 2-(tert-butyloxycarbonylamino)pyridine, which is then reacted with tert-butyllithium and DMF to obtain the final product.
Synthesis
38427-94-0
68-12-2
116026-94-9
Step 2: Synthesis of tert-butyl 3-formylpyridin-2-ylcarbamate (9b) To a solution of compound 9a (14.0 g, 72 mmol) in anhydrous ether (500 mL) at -78 °C and under nitrogen protection, tert-butyllithium (1.7 M, 106 mL, 180 mmol) was slowly added. The reaction mixture was slowly warmed to 0 °C and stirred at this temperature for 1 hour. Subsequently, anhydrous N,N-dimethylformamide (8.0 mL, 103 mmol) was added rapidly under vigorous stirring. The reaction mixture was continued to be stirred at 0 °C for 10 min and then quenched with a half-saturated aqueous ammonium chloride solution. The aqueous layer was separated and extracted twice with ethyl acetate (EA). The organic layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by column chromatography (eluent: petroleum ether/ethyl acetate = 3/1) to afford the target product 9b (8.0 g, 52% yield) as a white solid.
References
[1] Patent: WO2013/64231, 2013, A1. Location in patent: Page/Page column 45
[2] Heterocyclic Communications, 2011, vol. 17, # 1-2, p. 21 - 23
2-N-Boc-amino-3-formylpyridine Preparation Products And Raw materials
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View Lastest Price from 2-N-Boc-amino-3-formylpyridine manufacturers
Dideu Industries Group Limited
- Product
- 2-N-Boc-amino-3-formylpyridine 116026-94-9
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-27
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