ChemicalBook > CAS DataBase List > TRI-TERT-BUTYL 1 4 7 10-TETRAAZACYCLODOD

TRI-TERT-BUTYL 1 4 7 10-TETRAAZACYCLODOD

Product Name
TRI-TERT-BUTYL 1 4 7 10-TETRAAZACYCLODOD
CAS No.
137076-54-1
Chemical Name
TRI-TERT-BUTYL 1 4 7 10-TETRAAZACYCLODOD
Synonyms
DOTA-tris(t-Bu ester);TA-DOTA;NH2-PEG4-DOTA-GA;DOTA-tri(t-butyl ester);DOTA-tris(tert-butyl ester) Novabiochem;(4,7,10-Tris-tert-butoxycarbonylmethyl-1,4,7,10tetraaza-cyclododec-1-yl)-acetic acid;2-(4,7,10-TRIS(2-TERT-BUTOXY-2-OXOETHYL)-1,4,7,10-TETRAAZACYCLODODECAN-1-YL)ACETIC ACID;1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1,4,7-tris(1,1-dimethylethyl) ester;DOTA(3tBu);Tri-tert<
CBNumber
CB1497261
Molecular Formula
C28H52N4O8
Formula Weight
572.73
MOL File
137076-54-1.mol
More
Less

TRI-TERT-BUTYL 1 4 7 10-TETRAAZACYCLODOD Property

Melting point:
129-131℃
Boiling point:
632.1±55.0 °C(Predicted)
Density 
1.079
storage temp. 
Inert atmosphere,2-8°C
solubility 
Aqueous Base (Slightly), Chloroform (Slightly), DMSO (Slightly),Methanol(Slightly)
form 
Solid
pka
4.24±0.10(Predicted)
color 
Pale Beige
InChI
InChI=1S/C28H52N4O8/c1-26(2,3)38-23(35)19-30-12-10-29(18-22(33)34)11-13-31(20-24(36)39-27(4,5)6)15-17-32(16-14-30)21-25(37)40-28(7,8)9/h10-21H2,1-9H3,(H,33,34)
InChIKey
RVUXZXMKYMSWOM-UHFFFAOYSA-N
SMILES
N1(CC(OC(C)(C)C)=O)CCN(CC(O)=O)CCN(CC(OC(C)(C)C)=O)CCN(CC(OC(C)(C)C)=O)CC1
CAS DataBase Reference
137076-54-1
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
3
HS Code 
29339900
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
75061
Product name
Tri-tert-butyl 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate
Purity
≥95.0%(CHN)
Packaging
100mg
Price
$189
Updated
2025/07/31
TCI Chemical
Product number
T2642
Product name
Tri-tert-butyl 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetate
Purity
>97.0%(T)
Packaging
100mg
Price
$165
Updated
2025/07/31
TCI Chemical
Product number
T2642
Product name
Tri-tert-butyl 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetate
Purity
>97.0%(T)
Packaging
1g
Price
$679
Updated
2025/07/31
TRC
Product number
D494855
Product name
DOTA-tris(t-Buester)(~90%)
Packaging
25mg
Price
$85
Updated
2021/12/16
Chem-Impex
Product number
14713
Product name
4,7,10-Tri-(-butyloxycarbonylmethyl)- 1,4,7,10-tetraazacyclododecan-1-yl-acetic acid
Purity
≥ 98% (HPLC)
Packaging
250MG
Price
$105
Updated
2021/12/16
More
Less

TRI-TERT-BUTYL 1 4 7 10-TETRAAZACYCLODOD Chemical Properties,Usage,Production

Description

DOTA(OtBu)3 contains a DOTA moiety with t-butyl groups which can be used as a chelating agent for cations and is commonly used for imaging diagnostics. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Uses

DOTA-tris (t-Bu ester), is a Bifunctional chelator, that can be used in the preparation of gadolinium complexes as MRI blood contrast agents.

Uses

Tri-tert-butyl 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate (tri BOC-DOTA) can be employed as a reactant to prepare:

  • Gadolinium ion functionalized with DOTA-LAE (lactobionic acid-ethylenediamine), which is used as a contrast agent for magnetic resonance imaging (MRI).
  • DOTA-conjugates of ursolic acid and ZD2 peptide 64Cu-DOTA conjugates.

reaction suitability

reagent type: fluorescent-labelling reagent

IC 50

RDC Bifunctional Chelator

TRI-TERT-BUTYL 1 4 7 10-TETRAAZACYCLODOD Preparation Products And Raw materials

Raw materials

Potassium carbonate Cyclen Triethylamine Bromoacetic acid tert-Butyl bromoacetate

Preparation Products

More
Less

TRI-TERT-BUTYL 1 4 7 10-TETRAAZACYCLODOD Suppliers

Belgium 1 Canada 3 China 229 Czech Republic 1 Germany 3 India 8 Japan 3 South Korea 1 Spain 1 Switzerland 3 United Kingdom 7 United States 35 Global 295
Tel
17602663561
Email
public@dreamchem.cn
Country
China
ProdList
993
Advantage
58
Tel
022-83705301 13752403750
Fax
022-83705301
Email
2966024760@qq.com
Country
China
ProdList
873
Advantage
55
Tel
0570-3081766 18357083060
Fax
0570-3072337
Email
sales@qzamkbio.com
Country
China
ProdList
1046
Advantage
55
Tel
15666881566
Email
449211804@qq.com
Country
China
ProdList
46
Advantage
58
Tel
025-57018978 18251899859
Fax
025-57018008
Email
sales@chalf-pharm.com
Country
China
ProdList
5674
Advantage
50
Tel
0371-55055611 18137792234
Fax
QQ：3002694073
Email
3002694073@qq.com
Country
China
ProdList
9987
Advantage
58
Tel
176345344 7 17634854698
Email
1959525201@qq.com
Country
China
ProdList
10000
Advantage
58
Tel
17612188245
Fax
QQ 2816925681
Email
2816925681@qq.com
Country
China
ProdList
2989
Advantage
58
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Tel
025-86918202 4000255188
Fax
86-025-86918232
Email
sales@pharmablock.com
Country
China
ProdList
5000
Advantage
55
More
Less

View Lastest Price from TRI-TERT-BUTYL 1 4 7 10-TETRAAZACYCLODOD manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
TRI-TERT-BUTYL 1 4 7 10-TETRAAZACYCLODOD 137076-54-1
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-24
Xian confluore Biological Technology Co., Ltd.
Product
DOTA-(COOt-Bu)3 137076-54-1
Price
US $0.00/g
Min. Order
10g
Purity
>95.00%
Supply Ability
10g
Release date
2024-04-01
Honest Joy Holdings Limited
Product
TRI-TERT-BUTYL14710-TETRAAZACYCLODOD 137076-54-1
Price
US $0.00/KG
Min. Order
1KG
Purity
97.7%
Supply Ability
100 tons
Release date
2022-01-14

137076-54-1, TRI-TERT-BUTYL 1 4 7 10-TETRAAZACYCLODODRelated Search:

Tri-tert-butylphosphine TRI-TERT-BUTYLPHOSPHONIUM TETRAPHENYLBORATE Tri-tert-butylphosphine tetrafluoroborate Methyl trichloroacetate 1,4,7-tris-Boc-1,4,7,10-tetraaza-cyclododecane Tri-tert-butyl 1,4,7,10-Tetraazacyclododecane-1,4,7-triacetate HydrobroMide TRI-T-BUTYL 1 4 7 10-TETRAAZACYCLODODECA 1,4,7-Tris(ethoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane DOTA TRI-TERT-BUTYL 1 4 7 10-TETRAAZACYCLODOD 1,7-Bis(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane Cyclen

  • DOTA-tris(t-Bu ester)
  • Tri-tert-butyl 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetate DOTA-tris(tBu)ester
  • 2-[4,7,10-tris[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]-1,4,7,10-tetrazacyclododec-1-yl]acetic acid
  • (4,7,10-Tris-tert-butoxycarbonylmethyl-1,4,7,10tetraaza-cyclododec-1-yl)-acetic acid
  • Tri-<i>tert</i>-butyl 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetate
  • DOTA-tris(tert-butyl ester) Novabiochem
  • 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1,4,7-tris(1,1-dimethylethyl) ester
  • TRI-TERT-BUTYL 1 4 7 10-TETRAAZACYCLODOD
  • TRI-TERT-BUTYL 1,4,7,10-TETRAAZACYCLODODECANE-TETRAACETATE
  • 2-(4,7,10-tris(2-tert-butoxy-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl)acet
  • 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic Acid Tri-tert-butyl Ester
  • 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, tris(1,1-diMethylethyl) ester
  • 2-(4,7,10-TRIS(2-TERT-BUTOXY-2-OXOETHYL)-1,4,7,10-TETRAAZACYCLODODECAN-1-YL)ACETIC ACID
  • 1,4,7,10-Tetraazacyclododecane-1,4,7-tris-tert-butyl acetate-10-acetic acid
  • DOTA-tris (t-Bu ester)(B-260)
  • 1,4,7 -Boc-1,4,7,10- tetraazacyclododecane Cyclododecane -10- acid
  • S-2-(4-Isothiocyanatobenzyl)-1, 4, 7, 10-tetraazacyclododecane tetraacetic acid
  • NH2-PEG4-DOTA-GA
  • TA-DOTA
  • DOTA-tris(t-Butyl ester)
  • DOTA-tris (t-Bu ester) (~90%)
  • 2-[4,7,10-tris(2-tert-butoxy-2-oxo-ethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid
  • DOTA-(COOt-Bu)3
  • TRI-TERT-BUTYL 1 4 7 10-TETRAAZACYCLODOD USP/EP/BP
  • DOTA-tri(t-butyl ester)
  • 2-{4,7,1-tris[2-(tert-butoxy)-2-oxoethyl]-1,4,7,1-tetraazacyclododecan-1-yl}acetic acid
  • Tri-tert-butyl 1,4,7,1-tetraazacyclododecane-1,4,7,1-tetraacetate
  • Tianfu Chem TRI-TERT-BUTYL 1 4 7 10-TETRAAZACYCLODOD
  • 1,4,7-tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane-10-acetic acid
  • DOTA-tris(tert-butyl ester)
  • 2-[4,7,10-tris[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]-1,4,7,10-tetrazacyclododec-1-yl]aceticaci
  • Tri-tert-butyl 1,4,7,10-Tetraazacyclododecane-1,4,7,11-tetraacetate
  • DOTA tri(tert-butyl) ester
  • DOTA-Tris(tBu)
  • DOTA(3tBu)
  • Tri-<i>tert<
  • Gadobutrol Impurity 199
  • 137076-54-1
  • 37076-54-1
  • C28H52N4O8
  • RDC Linker
  • PDC Linker