ChemicalBook > CAS DataBase List > TRI-TERT-BUTYL 1 4 7 10-TETRAAZACYCLODOD

TRI-TERT-BUTYL 1 4 7 10-TETRAAZACYCLODOD

Product Name
TRI-TERT-BUTYL 1 4 7 10-TETRAAZACYCLODOD
CAS No.
137076-54-1
Chemical Name
TRI-TERT-BUTYL 1 4 7 10-TETRAAZACYCLODOD
Synonyms
DOTA-tris(t-Bu ester);TA-DOTA;NH2-PEG4-DOTA-GA;DOTA-tri(t-butyl ester);DOTA-tris(tert-butyl ester) Novabiochem;(4,7,10-Tris-tert-butoxycarbonylmethyl-1,4,7,10tetraaza-cyclododec-1-yl)-acetic acid;2-(4,7,10-TRIS(2-TERT-BUTOXY-2-OXOETHYL)-1,4,7,10-TETRAAZACYCLODODECAN-1-YL)ACETIC ACID;1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1,4,7-tris(1,1-dimethylethyl) ester;DOTA(3tBu);Tri-tert<
CBNumber
CB1497261
Molecular Formula
C28H52N4O8
Formula Weight
572.73
MOL File
137076-54-1.mol
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TRI-TERT-BUTYL 1 4 7 10-TETRAAZACYCLODOD Property

Melting point:
129-131℃
Boiling point:
632.1±55.0 °C(Predicted)
Density 
1.079
storage temp. 
Inert atmosphere,2-8°C
solubility 
Aqueous Base (Slightly), Chloroform (Slightly), DMSO (Slightly),Methanol(Slightly)
form 
Solid
pka
4.24±0.10(Predicted)
color 
Pale Beige
InChI
InChI=1S/C28H52N4O8/c1-26(2,3)38-23(35)19-30-12-10-29(18-22(33)34)11-13-31(20-24(36)39-27(4,5)6)15-17-32(16-14-30)21-25(37)40-28(7,8)9/h10-21H2,1-9H3,(H,33,34)
InChIKey
RVUXZXMKYMSWOM-UHFFFAOYSA-N
SMILES
N1(CC(OC(C)(C)C)=O)CCN(CC(O)=O)CCN(CC(OC(C)(C)C)=O)CCN(CC(OC(C)(C)C)=O)CC1
CAS DataBase Reference
137076-54-1
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
3
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
75061
Product name
Tri-tert-butyl 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate
Purity
≥95.0%(CHN)
Packaging
100mg
Price
$189
Updated
2025/07/31
TCI Chemical
Product number
T2642
Product name
Tri-tert-butyl 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetate
Purity
>97.0%(T)
Packaging
100mg
Price
$165
Updated
2025/07/31
TCI Chemical
Product number
T2642
Product name
Tri-tert-butyl 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetate
Purity
>97.0%(T)
Packaging
1g
Price
$679
Updated
2025/07/31
TRC
Product number
D494855
Product name
DOTA-tris(t-Buester)(~90%)
Packaging
25mg
Price
$85
Updated
2021/12/16
Chem-Impex
Product number
14713
Product name
4,7,10-Tri-(-butyloxycarbonylmethyl)- 1,4,7,10-tetraazacyclododecan-1-yl-acetic acid
Purity
≥ 98% (HPLC)
Packaging
250MG
Price
$105
Updated
2021/12/16
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TRI-TERT-BUTYL 1 4 7 10-TETRAAZACYCLODOD Chemical Properties,Usage,Production

Description

DOTA(OtBu)3 contains a DOTA moiety with t-butyl groups which can be used as a chelating agent for cations and is commonly used for imaging diagnostics. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Uses

DOTA-tris (t-Bu ester), is a Bifunctional chelator, that can be used in the preparation of gadolinium complexes as MRI blood contrast agents.

Uses

Tri-tert-butyl 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate (tri BOC-DOTA) can be employed as a reactant to prepare:

  • Gadolinium ion functionalized with DOTA-LAE (lactobionic acid-ethylenediamine), which is used as a contrast agent for magnetic resonance imaging (MRI).
  • DOTA-conjugates of ursolic acid and ZD2 peptide 64Cu-DOTA conjugates.

reaction suitability

reagent type: fluorescent-labelling reagent

IC 50

RDC Bifunctional Chelator

TRI-TERT-BUTYL 1 4 7 10-TETRAAZACYCLODOD Preparation Products And Raw materials

Raw materials

Potassium carbonate Cyclen Triethylamine Bromoacetic acid tert-Butyl bromoacetate

Preparation Products

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TRI-TERT-BUTYL 1 4 7 10-TETRAAZACYCLODOD Suppliers

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View Lastest Price from TRI-TERT-BUTYL 1 4 7 10-TETRAAZACYCLODOD manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
TRI-TERT-BUTYL 1 4 7 10-TETRAAZACYCLODOD 137076-54-1
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-24
Xian confluore Biological Technology Co., Ltd.
Product
DOTA-(COOt-Bu)3 137076-54-1
Price
US $0.00/g
Min. Order
10g
Purity
>95.00%
Supply Ability
10g
Release date
2024-04-01
Honest Joy Holdings Limited
Product
TRI-TERT-BUTYL14710-TETRAAZACYCLODOD 137076-54-1
Price
US $0.00/KG
Min. Order
1KG
Purity
97.7%
Supply Ability
100 tons
Release date
2022-01-14

137076-54-1, TRI-TERT-BUTYL 1 4 7 10-TETRAAZACYCLODODRelated Search:

Tri-tert-butylphosphine TRI-TERT-BUTYLPHOSPHONIUM TETRAPHENYLBORATE Tri-tert-butylphosphine tetrafluoroborate Methyl trichloroacetate 1,4,7-tris-Boc-1,4,7,10-tetraaza-cyclododecane Tri-tert-butyl 1,4,7,10-Tetraazacyclododecane-1,4,7-triacetate HydrobroMide TRI-T-BUTYL 1 4 7 10-TETRAAZACYCLODODECA 1,4,7-Tris(ethoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane DOTA TRI-TERT-BUTYL 1 4 7 10-TETRAAZACYCLODOD 1,7-Bis(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane Cyclen

  • DOTA-tris(t-Bu ester)
  • Tri-tert-butyl 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetate DOTA-tris(tBu)ester
  • 2-[4,7,10-tris[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]-1,4,7,10-tetrazacyclododec-1-yl]acetic acid
  • (4,7,10-Tris-tert-butoxycarbonylmethyl-1,4,7,10tetraaza-cyclododec-1-yl)-acetic acid
  • Tri-<i>tert</i>-butyl 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetate
  • DOTA-tris(tert-butyl ester) Novabiochem
  • 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1,4,7-tris(1,1-dimethylethyl) ester
  • TRI-TERT-BUTYL 1 4 7 10-TETRAAZACYCLODOD
  • TRI-TERT-BUTYL 1,4,7,10-TETRAAZACYCLODODECANE-TETRAACETATE
  • 2-(4,7,10-tris(2-tert-butoxy-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl)acet
  • 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic Acid Tri-tert-butyl Ester
  • 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, tris(1,1-diMethylethyl) ester
  • 2-(4,7,10-TRIS(2-TERT-BUTOXY-2-OXOETHYL)-1,4,7,10-TETRAAZACYCLODODECAN-1-YL)ACETIC ACID
  • 1,4,7,10-Tetraazacyclododecane-1,4,7-tris-tert-butyl acetate-10-acetic acid
  • DOTA-tris (t-Bu ester)(B-260)
  • 1,4,7 -Boc-1,4,7,10- tetraazacyclododecane Cyclododecane -10- acid
  • S-2-(4-Isothiocyanatobenzyl)-1, 4, 7, 10-tetraazacyclododecane tetraacetic acid
  • NH2-PEG4-DOTA-GA
  • TA-DOTA
  • DOTA-tris(t-Butyl ester)
  • DOTA-tris (t-Bu ester) (~90%)
  • 2-[4,7,10-tris(2-tert-butoxy-2-oxo-ethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid
  • DOTA-(COOt-Bu)3
  • TRI-TERT-BUTYL 1 4 7 10-TETRAAZACYCLODOD USP/EP/BP
  • DOTA-tri(t-butyl ester)
  • 2-{4,7,1-tris[2-(tert-butoxy)-2-oxoethyl]-1,4,7,1-tetraazacyclododecan-1-yl}acetic acid
  • Tri-tert-butyl 1,4,7,1-tetraazacyclododecane-1,4,7,1-tetraacetate
  • Tianfu Chem TRI-TERT-BUTYL 1 4 7 10-TETRAAZACYCLODOD
  • 1,4,7-tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane-10-acetic acid
  • DOTA-tris(tert-butyl ester)
  • 2-[4,7,10-tris[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]-1,4,7,10-tetrazacyclododec-1-yl]aceticaci
  • Tri-tert-butyl 1,4,7,10-Tetraazacyclododecane-1,4,7,11-tetraacetate
  • DOTA tri(tert-butyl) ester
  • DOTA-Tris(tBu)
  • DOTA(3tBu)
  • Tri-<i>tert<
  • Gadobutrol Impurity 199
  • 137076-54-1
  • 37076-54-1
  • C28H52N4O8
  • RDC Linker
  • PDC Linker