ChemicalBook > CAS DataBase List > 12-Crown-4

12-Crown-4

Product Name
12-Crown-4
CAS No.
294-93-9
Chemical Name
12-Crown-4
Synonyms
Crown;1,4,7,10-TETRAOXACYCLODODECANE;12-CROWN 4-ETHER;Eoct;12C4;12 C 4;12-C-4;12-CROWN-4;12-Crown-4,97%;LITHIUM IONOPHORE V
CBNumber
CB8752442
Molecular Formula
C8H16O4
Formula Weight
176.21
MOL File
294-93-9.mol
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12-Crown-4 Property

Melting point:
16 °C (lit.)
Boiling point:
61-70 °C/0.5 mmHg (lit.)
Density 
1.089 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.463(lit.)
Flash point:
>230 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
Liquid After Melting
Specific Gravity
1.115 (20℃)
color 
Clear colorless to slightly yellow
Water Solubility 
MISCIBLE
Sensitive 
Air Sensitive
BRN 
1363064
CAS DataBase Reference
294-93-9(CAS DataBase Reference)
NIST Chemistry Reference
12-Crown-4(294-93-9)
EPA Substance Registry System
1,4,7,10-Tetraoxacyclododecane (294-93-9)
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Safety

Hazard Codes 
T+,Xn,Xi
Risk Statements 
26-36/37/38-20/21/22
Safety Statements 
28-36/37-45-36-26
RIDADR 
UN 2810
WGK Germany 
3
RTECS 
XF0550000
F 
3-9-23
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29329995
Toxicity
LD50 oral in rat: 2830mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H330Fatal if inhaled

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
194905
Product name
12-Crown-4
Purity
98%
Packaging
1g
Price
$62.5
Updated
2024/03/01
Sigma-Aldrich
Product number
194905
Product name
12-Crown-4
Purity
98%
Packaging
5g
Price
$148
Updated
2024/03/01
TCI Chemical
Product number
C0858
Product name
12-Crown 4-Ether
Purity
>95.0%(GC)
Packaging
1mL
Price
$54
Updated
2024/03/01
TCI Chemical
Product number
C0858
Product name
12-Crown 4-Ether
Purity
>95.0%(GC)
Packaging
5mL
Price
$177
Updated
2024/03/01
Alfa Aesar
Product number
A11972
Product name
12-Crown-4, 98%
Packaging
1g
Price
$76.65
Updated
2024/03/01
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12-Crown-4 Chemical Properties,Usage,Production

Chemical Properties

clear colorless to slightly yellow liquid after

Uses

It serves as an aprotic "solvent" for alkali metals, the sodium solution is a strong reducing agent.

Uses

12-Crown-4 can be used as:

  • A promoter in the synthesis of poly(diethylsiloxane) (PDES) from monomer hexaethylcyclotrisiloxane using NaOH as a catalyst via anionic ring-opening polymerization.
  • As an additive in the preparation of triarylmethane derivatives by palladium-catalyzed cross coupling reaction of aryl bromides with diarylmethane derivatives.
  • A phase transfer catalyst in organic synthesis.

Definition

ChEBI: A crown ether that is cyclododecane in which the carbon atoms at positions 1, 4, 7 and 10 have been replaced by oxygen atoms.

Synthesis Reference(s)

Tetrahedron Letters, 15, p. 4029, 1974 DOI: 10.1016/S0040-4039(01)92075-1

General Description

12-Crown-4 is a crown ether generally used as a ligand in coordination chemistry. It is also known as lithium ionophore because of its strong chelating property specific to lithium cation.

Purification Methods

The distilled crude product has to be recrystallised from pentane at -20o to remove acyclic material. It is then dried over P2O5. It complexes Li. [Anet et al. Acta Chem Scand 27 3395 1973, Beilstein 19/11 V 334.]

12-Crown-4 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 12-Crown-4 manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
12-Crown-4 294-93-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Career Henan Chemical Co
Product
12-Crown-4 294-93-9
Price
US $7.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100KG
Release date
2018-12-17
Career Henan Chemical Co
Product
12-Crown-4 294-93-9
Price
US $7.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100KG
Release date
2018-12-17

294-93-9, 12-Crown-4Related Search:

1,7-DIAZA-12-CROWN-4,4,10-DIAZA-12-CROWN 4-ETHER BIS[(12-CROWN-4)METHYL] DODECYLMETHYLMALONATE 2-(HYDROXYMETHYL)-12-CROWN 4-ETHER Tetraaza 12-crown-4 1-AZA-12-CROWN 4-ETHER,1-AZA-12-CROWN-4,AZA-12-CROWN-4,aza-12-crown-499.5+% BENZO-12-CROWN-4,BENZO-12-CROWN 4-ETHER,Benzo-12-crown-4, 99+%,BENZO-12-CROWN-4 98+% 1-aza-12-crown-5 TETRAAZA-12-CROWN-4-1,4,7,10-TETRAACETIC ACID,TETRAAZA-12-CROWN-4 TETRAACETIC ACID AMMONIUM SALT (SEE 2923) TETRAAZA-12-CROWN-4 TETRAHYDROCHLORIDE CYCLODODECANE N-METHYLAZA-12-CROWN-4 4-TERT-BUTYL-CALIX[4]ARENE-CROWN-4-COMPLEX 1-BENZYL-1-AZA-12-CROWN-4,N-BENZYLAZA-12-CROWN-4 TETRAAZA-12-CROWN-4 TETRAHYDROGENSULFATE 12-Crown-4 Cyclohexyl-12-crown-4 Tetraaza 12-crown-4-tetraacetic acid derivative BIS[(12-CROWN-4)METHYL] 2,2-DIDODECYLMALONATE

  • LITHIUM IONOPHORE V
  • CROWN ETHER/12-CROWN-4
  • Crown
  • Eoct
  • Ethylene oxide cyclic tetramer
  • 1,4,7,10-TETRAOXYCYCLODODECANE
  • 1,4,7,10-TETRAOXACYCLODODECANE
  • 12-CROWN 4-ETHER
  • 12-CROWN-4
  • 1,4,7,10-Tetraoxacyclododecane, 12-Crown-4
  • 12-Crown-4,97%
  • CROWN ETHER/12-CROWN-4 FOR SYNTHESIS
  • 12-Crown-4 Cyclic tetraMer of ethylene oxide which is specific for the lithiuM cation., 98%
  • 12-Crown-4(1,4,7,10-Tetraoxacyclododecane)
  • 12-Crown 4-Ether &gt
  • 294-93-9 12-Crown-4
  • 12 C 4
  • 12C4
  • 12-C-4
  • 294-93-9
  • 294-93-6
  • Chelation/Complexation Compounds
  • Macrocycles for Host-Guest Chemistry
  • Crown Ethers
  • Synthetic Reagents
  • Crown Ethers
  • Functional Materials
  • Macrocycles for Host-Guest Chemistry