DOTA

ChemicalBook > CAS DataBase List > DOTA

Product Name: DOTA
CAS No.: 60239-18-1
Chemical Name: DOTA
Synonyms: TETRAXETAN;1,4,7,10-TETRAAZACYCLODODECANE-1,4,7,10-TETRAACETIC ACID;2,2',2'',2'''-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid;DOTA;TETRAAZA;98% DOTA;NSC 681107;DOTA, ≥97%;DOTA(M-140);TetraxetanuM
CBNumber: CB9398467
Molecular Formula: C16H28N4O8
Formula Weight: 404.42
MOL File: 60239-18-1.mol

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DOTA Property

Melting point:: 267 °C
Boiling point:: 701.6±60.0 °C(Predicted)
Density: 1.321
storage temp.: Sealed in dry,Room Temperature
solubility: Water (Slightly, Heated), Methanol (Slightly)
pka: 2.16±0.10(Predicted)
form: Powder
color: white
BRN: 1186987
Stability:: Hygroscopic

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
F: 3-10-34
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 86734
Product name: 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid
Purity: ≥97.0% (CHN)
Packaging: 50mg
Price: $138
Updated: 2024/03/01

Sigma-Aldrich

Product number: 86734
Product name: 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid
Purity: ≥97.0% (CHN)
Packaging: 250mg
Price: $148
Updated: 2024/03/01

TCI Chemical

Product number: T1875
Product name: 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic Acid
Purity: >97.0%(T)
Packaging: 200mg
Price: $157
Updated: 2024/03/01

TCI Chemical

Product number: T1875
Product name: 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic Acid
Purity: >97.0%(T)
Packaging: 1g
Price: $552
Updated: 2024/03/01

Strem Chemicals

Product number: 07-1942
Product name: 1,4,7,10-Tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid, min. 98% DOTA
Packaging: 250mg
Price: $120
Updated: 2024/03/01

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DOTA Chemical Properties,Usage,Production

Chemical Properties

Colourless crystals

Uses

1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) is a macrocyclic complexing agent.

It has been used for radiolabeling of carbon nanotube bioconjugates by chelating ⁶⁴Cu radioisotope.
DOTA can be activated with N-hydroxysulfosuccinimidyl for conjugation with monoclonal antibodies in clinical radioimmunotherapy.
It can form complexes with gadolinium for application as MRI contrast agents.
Metal complexes of DOTA-peptide conjugates can be used as therapeutic radiopharmaceuticals.

Uses

Bifunctional DOTA aconjugates to peptides and has become an established strategy for constructing target-specific metal containing agents including targeted MRI contrast agents and diagnostic and ther apeutic radiopharmaceuticals.

Definition

ChEBI: An azamacrocyle in which four nitrogen atoms at positions 1, 4, 7 and 10 of a twelve-membered ring are each substituted with a carboxymethyl group.

DOTA Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from DOTA manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: DOTA 60239-18-1
Price: US $0.00/g
Min. Order: 100g
Purity: >95.00%
Supply Ability: 100g
Release date: 2024-04-01

Hebei Yanxi Chemical Co., Ltd.

Product: DOTA 60239-18-1
Price: US $10.00-1.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 30 tons
Release date: 2023-09-07

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 1,4,7,10-Tetraazacyclododecane- 1,4,7,10-tetraacetic-acid 60239-18-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-08

60239-18-1, DOTARelated Search:

1,4,7,10-Tetrakis(ethoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane DOTA Gadoteric acid 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 2-[(4-isothiocyanatophenyl)methyl]- TETRYL 12-Crown-4 Eu-DOTA,Europium DOTA TRI-TERT-BUTYL 1 4 7 10-TETRAAZACYCLODOD GADOMELITOL DOTA-[TYR3]-OCTREOTATE,DOTA-[TYR3]-OCTREOTIDE ACID,DOTA-FCYWKTCT (DISULFIDE BRIDGE: 2-7),DOTA-D-PHE-CYS-TYR-D-TRP-LYS-THR-CYS-THR-OH (DISULFIDE BRIDGE: 2-7) DOTA-D-PHE-CYS-TYR-D-TRP-LYS-THR-CYS-THR-OL (DISULFIDE BRIDGE: 2-7) gadolinium DOTA meglumine DOTA-BIM-23014:DOTA-Lanreotide,DOTA-Lanreotide DOTA-(Tyr3)-Octreotate Iron DOTA Sodium Salt DOTA-glycyl-glycyl-glycyl-(4-nitrophenyl)alanine amide DOTA-NOC, DOTA-[Nal3]-octreotide,DOTA-NOC yttrium-90-DOTA-peptide-chimeric L6

TETRAXETAN

1,4,7,10-Tetraazacyclododecane-N,N',N'',N'''-tetraaceticacid,min.98%DOTA

1,4,7,10-TETRAAZACYCLODODECANE-1,4,7,10-TETRAACETIC ACID

1,4,7,10-TETRAAZACYCLODODECANE-1,4,7,10-TETRAACETIC ACID, FREE ACID

1,4,7,10-TETRAAZACYCLODODECANE-N,N',N'',N'''-TETRAACETIC ACID

DOTA

TETRAAZA-12-CROWN-4-1,4,7,10-TETRAACETIC ACID

NSC 681107

Gadobutrol Impurity 6（DOTA）

DOTA60239-18-1

TETRAAZA

DOTA(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic Acid)

Gadobutrol Impurity 12

2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl]acetic acid

2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid

TETRAAZA-12-CROWN-4 TETRAACETIC ACID AMMONIUM SALT (SEE 2923)

Tetraxetan/radical

1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetrakisacetic acid

2,2',2'',2'''-(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetryl)tetraacetic acid

2,2',2'',2'''-(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetryl)tetrakisacetic acid

1,4,7,10-TETRAAZACYCLODODECANE-N,N'',N , N''-TETRAACETIC ACID , (DOTA)

1,4,7,10-TETRAAZACYCLODODECANE-1,4,7,10-TETRAACETIC ACID DOTA

DOTA(M-140)

Tetraxetan/DOTA/1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid

1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid >=97.0% (CHN)

DOTA Tetraxetan 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid

2,2',2'',2'''-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid

4,7,10-Tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid

2,2',2'',2'''-(1,4,7,10-tetraazacyclododecane -1,4,7,10-tetrayl)tetraacetic acid(DOTA)

1,4,7,10-tetrakis(carboxymethyl)-1,4,7,10-tetraazacyclododecane

Tetraxetanum (DOTA)

1,4,7,10-Tetraazacyclododecan-N,N',N,N'-tetraacetic acid

TetraxetanuM

Atosiban impurity 9

Gadobutrol Impurity 35

DOTA, ≥97%

98% DOTA

TETRAXETAN(DOTA)

Tritracine tetraacetic acid

Gadolinium Butanol Impurity 6

Gadolinium Butanol Impurity 11

1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic

(3aR,4aS)-4a-(3-fluorophenyl)-1,3,3a,4a-tetrahydrocyclopropa[1,2-c]furan-1-one

DOTA (TETRAXETAN)

Gadolinium alcohol impurity 6

(1,4,7,10-tetra-carboxymethyl -1,4,7,10-teraaza-cyclododec -1-yl)-acetic acid(DOTA)

1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic Acid hydrate

2,2',2'',2'''-(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid

1,4,7,10-tetraazacyclododecane-N,N’,N’’,N’’’-tetraaceticacid(DOTA)

60239-18-1

60239-28-1

C16H28N4O8xH2O

C16H28N4O8

Synthetic Reagents

Crown Ethers

Chelation/Complexation Compounds

Achiral Nitrogen

Cy-N