Hydrocortisone sodium succinate
- Product Name
- Hydrocortisone sodium succinate
- CAS No.
- 125-04-2
- Chemical Name
- Hydrocortisone sodium succinate
- Synonyms
- solu-cortef;PREGN-4-ENE-3 20-DIONE 21-(3-CARBOXY-1-O XOPROPOXY)-11 17-DIHYDROXY-MONOSODIUM SA LT (11)-CORTISOL 21-(SODIUM SUCCINATE);u4905;corlan;Cortop;hycorace;oralsone;Arcocort;intracort;nordicort
- CBNumber
- CB0373175
- Molecular Formula
- C25H33O8.Na
- Formula Weight
- 484.52
- MOL File
- 125-04-2.mol
Hydrocortisone sodium succinate Property
- Melting point:
- 169.0-171.2°
- storage temp.
- −20°C
- solubility
- H2O: 50 mg/mL
- form
- powder
- color
- White to Off-White
- InChIKey
- HHZQLQREDATOBM-CODXZCKSSA-M
- CAS DataBase Reference
- 125-04-2(CAS DataBase Reference)
Safety
- WGK Germany
- 3
- RTECS
- GM9015000
N-Bromosuccinimide Price
- Product number
- H4881
- Product name
- Hydrocortisone 21-hemisuccinate sodium salt
- Purity
- ≥90% (HPLC)
- Packaging
- 1g
- Price
- $182
- Updated
- 2024/03/01
- Product number
- H2270
- Product name
- Hydrocortisone 21-hemisuccinate sodium salt
- Purity
- powder, BioReagent, suitable for cell culture
- Packaging
- 100mg
- Price
- $43.4
- Updated
- 2024/03/01
- Product number
- 18226
- Product name
- Hydrocortisone 21-hemisuccinate (sodium salt)
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $30
- Updated
- 2024/03/01
- Product number
- 18226
- Product name
- Hydrocortisone 21-hemisuccinate (sodium salt)
- Purity
- ≥98%
- Packaging
- 1g
- Price
- $178
- Updated
- 2024/03/01
- Product number
- H4881
- Product name
- Hydrocortisone 21-hemisuccinate sodium salt
- Purity
- ≥90% (HPLC)
- Packaging
- 100mg
- Price
- $36.3
- Updated
- 2024/03/01
Hydrocortisone sodium succinate Chemical Properties,Usage,Production
Uses
Hydrocortisone Hemisuccinate Sodium is a derivative of the glucocorticoid Hydrocortisone (H714615). Hydrocortisone Hemisuccinate Sodium is used as an anti-inflammatory agent. Hydrocortisone Hemisuccinate Sodium is widely used in the treatment of asthma, endocrine disorders, dermatological disorders, allergic states, etc.
Uses
Hydrocortisone 21-hemisuccinate is a water-soluble form of the endogenous hormone cortisol. It can bind to glucocorticoid receptors, initiating the transcription of anti-inflammatory and immunosuppressive mediators and inhibiting proinflammatory cytokine activity (IC50 = 6.7 μM for IL-6). It is commonly used to supplement media for long-term epithelial or endothelial cell cultures and to differentiate pluripotent stem cells.
Uses
Hydrocortisone sodium succinate is a derivative of the glucocorticoid Hydrocortisone (H714615). Hydrocortisone Hemisuccinate Sodium is used as an anti-inflammatory agent. Hydrocortisone sodium succinate is widely used in the treatment of asthma, endocrine disorders, dermatological disorders, allergic states, etc.
Definition
ChEBI: Hydrocortisone Sodium Succinate is an organic molecular entity.
brand name
A-Hydrocort (Abbott); A-Hydrocort (Hospira); Solu-Cortef (Pharmacia & Upjohn).
General Description
Hydrocortisone for use in epithelial and endothelial adherent cell culture applications.
Drug interactions
Potentially hazardous interactions with other drugs
Aldesleukin: avoid concomitant use.
Antibacterials: metabolism accelerated by rifampicin;
metabolism possibly inhibited by erythromycin;
concentration of isoniazid possibly reduced.
Anticoagulants: efficacy of coumarins and
phenindione may be altered.
Antiepileptics: metabolism accelerated by
carbamazepine, fosphenytoin, phenobarbital,
phenytoin and primidone.
Antifungals: increased risk of hypokalaemia with
amphotericin - avoid; metabolism possibly inhibited
by itraconazole and ketoconazole.
Antivirals: concentration possibly increased by ritonavir.
Ciclosporin: rare reports of convulsions in patients
on ciclosporin and high-dose corticosteroids.
Cobicistat: concentration of hydrocortisone possibly
increased - increased risk of adrenal suppression.
Diuretics: enhanced hypokalaemic effects of
acetazolamide, loop diuretics and thiazide diuretics.
Vaccines: high dose corticosteroids can impair
immune response to vaccines - avoid concomitant
use with live vaccines.
Metabolism
Hydrocortisone is metabolised in the liver and most body tissues to hydrogenated and degraded forms such as tetrahydrocortisone and tetrahydrocortisol. These are excreted in the urine, mainly conjugated as glucuronides, with a very small proportion of unchanged hydrocortisone.
Hydrocortisone sodium succinate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Hydrocortisone sodium succinate manufacturers
- Product
- Hydrocortisone sodium succinate 125-04-2
- Price
- US $1.00/Kg/Bag
- Min. Order
- 100g
- Purity
- 97.0%~102.0%,USP41
- Supply Ability
- 200kg/month
- Release date
- 2021-06-01
- Product
- Hydrocortisone sodium succinate 125-04-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000tons
- Release date
- 2023-08-14
- Product
- Hydrocortisone sodium succinate 125-04-2
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2023-03-27