Adrenocorticotropic hormone drugs Indications Contraindications Adverse Reactions Precautions Chemical Property Uses Production methods
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Hydrocortisone acetate

Adrenocorticotropic hormone drugs Indications Contraindications Adverse Reactions Precautions Chemical Property Uses Production methods
Product Name
Hydrocortisone acetate
CAS No.
50-03-3
Chemical Name
Hydrocortisone acetate
Synonyms
HYDROCORTISONE 21-ACETATE;CORTISOL ACETATE;CORTISOL 21-ACETATE;Cortef;Epifoam;Cortifoam;Fernisone;Carmol HC;Hc45;Mysone
CBNumber
CB7196805
Molecular Formula
C23H32O6
Formula Weight
404.5
MOL File
50-03-3.mol
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Hydrocortisone acetate Property

Melting point:
223 °C (dec.)(lit.)
Boiling point:
446.1°C (rough estimate)
alpha 
D25 +166° (c = 0.4 in dioxane); D25 +150.7° (c = 0.5 in acetone)
Density 
d420 1.289
refractive index 
1.4593 (estimate)
Flash point:
223°C
storage temp. 
0-6°C
solubility 
Practically insoluble in water, slightly soluble in anhydrous ethanol and in methylene chloride
pka
12.42±0.70(Predicted)
form 
Solid
color 
White to Off-White
Water Solubility 
Insoluble in water.
Decomposition 
223 ºC
Merck 
14,4787
BRN 
2066841
Stability:
Stable, but may be light or moisture sensitive. Incompatible with strong oxidizing agents.
LogP
2.190
CAS DataBase Reference
50-03-3(CAS DataBase Reference)
NIST Chemistry Reference
Hydrocortisone acetate(50-03-3)
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Safety

Hazard Codes 
Xn,T
Risk Statements 
63-10-45
Safety Statements 
36/37-45-53
WGK Germany 
3
RTECS 
GM8960000
HS Code 
29372100
Toxicity
LD50 intraperitoneal in mouse: 2300mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H1400000
Product name
Hydrocortisone acetate
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
H1400000
Price
$220
Updated
2024/03/01
Sigma-Aldrich
Product number
H4126
Product name
Hydrocortisone 21-acetate
Purity
≥98% (HPLC)
Packaging
1G
Price
$59
Updated
2023/06/20
Sigma-Aldrich
Product number
H4126
Product name
Hydrocortisone 21-acetate
Purity
≥98% (HPLC)
Packaging
5G
Price
$173
Updated
2023/06/20
Sigma-Aldrich
Product number
H4126
Product name
Hydrocortisone 21-acetate
Purity
≥98% (HPLC)
Packaging
10G
Price
$324
Updated
2023/06/20
Sigma-Aldrich
Product number
H3035
Product name
Hydrocortisone 21-acetate
Purity
meets USP testing specifications
Packaging
5G
Price
$157
Updated
2023/06/20
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Hydrocortisone acetate Chemical Properties,Usage,Production

Adrenocorticotropic hormone drugs

Hydrocortisone acetate is an adrenal hormone drugs, white crystalline powder, odorless, bitter taste. The melting point is 216~222 ℃, right optical. Slightly soluble in ethanol, ether, chloroform, acetone, insoluble in water. It was synthesized by In 17α-hydroxy progesterone.
Hydrocortisone acetate has important physiological activities such as anti-inflammatory, anti-viral, anti-allergic, anti-shock, reducing inflammatory exudation effect, commonly used in clinical adrenal insufficiency and autoimmune diseases. Preparations are injection, tablets, ointments and eye drops. Adding a small amount of hydrocortisone acetate in some cosmetics cortisol can increase the efficacy of anti-allergy and improve the degree of whitening of the skin, but long-term using of such substances can cause the skin produce hormone-dependent disease. Our cosmetics cosmetics specifications prescribedthathormone substances can not be added.

Indications

For allergic, non-infectious skin diseases and a number of proliferative skin disorders. Such as dermatitis, eczema, neurodermatitis, seborrheic dermatitis and itching psychosis.

Figure 1 the chemical structure formula of tetra-fluoroethane.

Contraindications

1. This medicine and matrix components allergy and allergic to other glucocorticoids are prohibited.
2. The primary bacterial, fungal and viral infectious skin diseases such as disabledare prohibited.
The above information is edited by the chemicalbook of KuiMing.

Adverse Reactions

Long-term using can cause local skin atrophy, telangiectasia, pigmentation, folliculitis, perioral dermatitis and secondary infection.

Precautions

1. Not long-term, large-scale use.
2. The coated parts such as a burning sensation, itching, swelling, etc., should stop the medication.

Chemical Property

White or almost white crystalline powder, odorless. Mp218-221.5 ℃; 25D + 166 ° (dioxane) Specific rotation [α]; ethanol maximum absorption at 240nm wavelength. Insoluble in water, slightly soluble in ethanol (1: 230) and chloroform (1: 150), insoluble in ether.

Uses

Corticosteroid drugs, have anti-inflammatory, anti-allergic, anti-toxins, anti-shock effect.

Production methods

Hydrocortisone and acetic anhydride in pyridine esterification.

Chemical Properties

white powder

Uses

Glucocorticoid

Uses

Hydrocortisone acetate is used to treat hemorrhoids and itching/swelling in the rectum and anus. It is used to treat certain intestinal problems (such as ulcerative colitis of the rectum and other rectal/anal inflammatory conditions).

Definition

ChEBI: Cortisol 21-acetate is a tertiary alpha-hydroxy ketone and a cortisol ester.

brand name

Cortef Acetate (Pharmacia & Upjohn); Cortifoam (Schwarz Pharma); Cortril (Pfizer); Dricort (Ingram); Hydrocortone (Merck).

Clinical Use

Corticosteroid:

Local inflammation of joints and soft tissue

Drug interactions

Potentially hazardous interactions with other drugs
Aldesleukin: avoid concomitant use.
Antibacterials: metabolism accelerated by rifampicin; metabolism possibly inhibited by erythromycin; concentration of isoniazid possibly reduced.
Anticoagulants: efficacy of coumarins and phenindione may be altered.
Antiepileptics: metabolism accelerated by carbamazepine, phenobarbital, fosphenytoin, phenytoin and primidone.
Antifungals: increased risk of hypokalaemia with amphotericin - avoid; metabolism possibly inhibited by itraconazole and ketoconazole.
Antivirals: concentration possibly increased by ritonavir.
Ciclosporin: rare reports of convulsions in patients on ciclosporin and high-dose corticosteroids
. Cobicistat: concentration of hydrocortisone possibly increased - increased risk of adrenal suppression.
Diuretics: enhanced hypokalaemic effects of acetazolamide, loop diuretics and thiazide diuretics.
Vaccines: high dose corticosteroids can impair immune response to vaccines - avoid concomitant use with live vaccines.

Metabolism

Hydrocortisone is metabolised in the liver and most body tissues to hydrogenated and degraded forms such as tetrahydrocortisone and tetrahydrocortisol. These are excreted in the urine, mainly conjugated as glucuronides, with a very small proportion of unchanged hydrocortisone.

Purification Methods

The acetate recrystallises from Me2CO/Et2O or aqueous Me2CO as hygroscopic monoclinic crystals. UV has max at 242 nm (A1cm 1% 390) in MeOH. Its solubility at 25o is: H2O (0.001%), EtOH (0.45%), MeOH (0.04%), Me2CO (1.1%), CHCl3 (0.5%), Et2O (0.15%), and it is very soluble in Me2NCHO. [Wendler et al. J Am Chem Soc 74 3630 1952; Antonucci et al. J Org Chem 18 7081 1953, Beilstein 8 IV 3424.]

Hydrocortisone acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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Hydrocortisone acetate Suppliers

Wuhan Xinru Chemical Co., Ltd.
Tel
15927387915 15337108568
Email
2769903731@qq.com
Country
China
ProdList
3338
Advantage
58
Nanjing Shizhou Biotechnology Co., Ltd
Tel
025-85563444 15850508050
Fax
18013869214
Email
rose.shi@synzest.com
Country
China
ProdList
292
Advantage
58
Jinan Wald Chemical Co., Ltd.
Tel
0531-88773586 13210588999
Fax
053188773586
Email
304264064@qq.com
Country
China
ProdList
195
Advantage
58
Hubei Aiputi Bioengineering Co., Ltd.
Tel
17762444226
Email
d17762444226@163.com
Country
China
ProdList
2402
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94838
Advantage
76
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3576
Advantage
66
Chembest Research Laboratories Limited
Tel
021-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6013
Advantage
61
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
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View Lastest Price from Hydrocortisone acetate manufacturers

Wuhan Haorong Biotechnology Co.,Ltd
Product
Hydrocortisone acetate 50-03-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500
Release date
2023-07-31
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
Hydrocortisone acetate 50-03-3
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2020-09-11
Hebei Yanxi Chemical Co., Ltd.
Product
cortisol 21-acetate 50-03-3
Price
US $40.00-40.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2023-09-21

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