CORTEXOLONE

Product Name: CORTEXOLONE
CAS No.: 152-58-9
Chemical Name: CORTEXOLONE
Synonyms: 11-DEOXYCORTISOL;CORTODOXONE;Deoxycortisol;11-DESOXYCORTISOL;11-deoxyhydrocortisone;11-desoxyhydrocortisone;17,21-DIHYDROXYPROGESTERONE;17-hydroxy-11-deoxycorticosterone;11-DEOXY-17-HYDROXYCORTICOSTERONE;4-Pregnene-17a,21-diol-3,20-dione
CBNumber: CB0493958
Molecular Formula: C21H30O4
Formula Weight: 346.46
MOL File: 152-58-9.mol

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CORTEXOLONE Property

Melting point:: 205-208 °C
Boiling point:: 401.19°C (rough estimate)
Density: 1.22±0.1 g/cm3 (20 ºC 760 Torr)
refractive index: 120 ° (C=1, Dioxane)
Flash point:: 9℃
storage temp.: Sealed in dry,Room Temperature
solubility: Dioxane (Slightly, Heated, Sonicated), DMSO (Slightly), Methanol (Slightly, Heated)
form: Solid
pka: 12?+-.0.60(Predicted)
color: White to Off-White
Water Solubility: 44.08mg/L(37 ºC)
Merck: 14,2932
Major Application: diagnostic assay manufacturing
hematology
histology
InChI: InChI=1S/C21H30O4/c1-19-8-5-14(23)11-13(19)3-4-15-16(19)6-9-20(2)17(15)7-10-21(20,25)18(24)12-22/h11,15-17,22,25H,3-10,12H2,1-2H3/t15-,16+,17+,19+,20+,21+/m1/s1
InChIKey: WHBHBVVOGNECLV-OBQKJFGGSA-N
SMILES: C1(=O)C=C2[C@](C)(CC1)[C@]1([H])[C@]([H])([C@@]3([H])[C@@](CC1)(C)[C@@](O)(C(=O)CO)CC3)CC2
CAS DataBase Reference: 152-58-9(CAS DataBase Reference)

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Safety

Hazard Codes: F,T
Risk Statements: 11-23/24/25-39/23/24/25
Safety Statements: 24/25-22-45-36/37-16-7
RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany: 3
RTECS: TU5011500
HS Code: 2937.23.5050
Storage Class: 11 - Combustible Solids
Toxicity: mouse,LD50,intravenous,100mg/kg (100mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#04684,

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H370Causes damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P311Call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: R200050
Product name: 17-ALPHA,21-DIHYDROXYPREGN-4-ENE-3,20-DIONE
Purity: Aldrich<sup>CPR</sup>
Packaging: 1 unit
Price: $30.7
Updated: 2025/07/31

Sigma-Aldrich

Product number: R0500
Product name: Reichstein’s substance S
Purity: ≥98%
Packaging: 1g
Price: $58.11
Updated: 2025/07/31

Sigma-Aldrich

Product number: D-061
Product name: 11-Deoxycortisol solution
Purity: 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
Packaging: 1mL
Price: $145
Updated: 2025/07/31

Sigma-Aldrich

Product number: R200050
Product name: 17-ALPHA,21-DIHYDROXYPREGN-4-ENE-3,20-DIONE
Purity: AldrichCPR
Packaging: 1MG
Price: $29.8
Updated: 2024/03/01

TCI Chemical

Product number: C1478
Product name: Cortexolone
Purity: >98.0%(HPLC)
Packaging: 1g
Price: $193
Updated: 2025/07/31

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CORTEXOLONE Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Uses

11-Deoxy Cortisol (Hydrocortisone EP Impurity F) is a glucocorticoid receptor binding.

Definition

ChEBI: 11-deoxycortisol is a deoxycortisol that is cortisol in which the hydroxy group at position 11 has been replaced by a hydrogen. It has a role as a mouse metabolite and a human metabolite. It is a glucocorticoid, a primary alpha-hydroxy ketone, a tertiary alpha-hydroxy ketone and a deoxycortisol.

in vivo

Cortodoxone (100 mg/kg; i.p.) increases tryptophan oxygenase (TO) activity and induces the secretion of corticosterone^[1].

Animal Model:	220-320g, adult male Wistar rats^[2]
Dosage:	100 mg/kg
Administration:	IP
Result:	Increased tryptophan oxygenase (TO) activity and induced the secretion of corticosterone.

IC 50

Human Endogenous Metabolite

CORTEXOLONE Preparation Products And Raw materials

Raw materials

Preparation Products

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CORTEXOLONE Suppliers

Americas 1 Belgium 2 Canada 3 China 190 Czech 1 Europe 2 France 2 Germany 4 India 13 Japan 3 Russia 1 South Korea 1 Switzerland 2 Ukraine 1 United Kingdom 11 United States 43 Global 280

Chongqing Chemieliva Pharmaceutical Co., Ltd.

Tel: 18696571988
Fax: +86 (23) 6777-0220
Email: amy.lei@chemieliva.com
Country: China
ProdList: 1556
Advantage: 60

Hunan Kaimir Biotechnology Co., Ltd.

Tel: 0731-+86-0731-89714511 +86-18602659358
Fax: 0731-89714511
Email: sales@chemapi.com.cn
Country: China
ProdList: 34
Advantage: 58

Wuhan Fortuna Chemical Co., Ltd

Tel: 027-59207852 13308628970
Fax: QQ:2779667926
Email: buy@fortunachem.com
Country: China
ProdList: 2628
Advantage: 58

Shanghai Peiling Biological Technology Co., LTD

Tel: 13127581762 13127581762
Email: peilingchem@sina.com
Country: China
ProdList: 552
Advantage: 58

Hubei Yuanmeng Biological Technology Co., Ltd.

Tel: 027-68897569 17740516530
Email: 1958216756@qq.com
Country: China
ProdList: 2920
Advantage: 58

Jiangsu Baiaoxinkang Pharmaceutical Technology Co. , Ltd.

Tel: 18015077019 18015077019
Email: jwang@bioscenepharma.com
Country: China
ProdList: 105
Advantage: 58

Hubei Peien Biotechnology Co., Ltd.

Tel: 15586415416 15586415416
Email: gracechem@sina.com
Country: China
ProdList: 414
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

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View Lastest Price from CORTEXOLONE manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Cortexolone 152-58-9
Price: US $0.00-0.00/kg
Min. Order: 10kg
Purity: 99.5%
Supply Ability: 1000kg
Release date: 2025-04-30

Watson Biotechnology Co.,Ltd

Product: Cortexolone 152-58-9
Price: US $0.00-0.00/G
Min. Order: 1G
Purity: 99
Supply Ability: 10KG
Release date: 2024-07-30

Shaanxi Dideu New Materials Co. Ltd

Product: CORTEXOLONE 152-58-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-05

152-58-9, CORTEXOLONERelated Search:

Hydrocortisone acetate CORTISOL-9,11,12,12-D4 Hydrocortisone sodium succinate Hydrocortisone 21-hemisuccinate Cortexolone 21-acetate,CORTEXOLONE ACETATE 11-ALPHA-HYDROCORTISONE CORTEXOLONE CORTISONE Flurandrenolide 6BETA-HYDROXYCORTISOL Cortisone acetate Hydrocortisone Hydrocortisone-17-butyrate Hydrocortisone sodium phosphate CORTISOL 17-VALERATE 4-PREGNEN-6-BETA, 17,21-TRIOL-3,11,20-TRIONE 4-PREGNEN-17,21-DIOL-3,11,20-TRIONE 21-GLUCOSIDURONATE 4-PREGNENE-11BETA,17ALPHA,21-TRIOL-3,20-DIONE 21-CAPRYLATE

(8R,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one

Hydrocortisone Impurity 6（Hydrocortisone EP Impurity F）

11-DEOXYCORTISOL; CORTEXOLONE; REICHSTEIN'S SUBSTANCE S

11-dioxy-cortiso

11-dioxycortisol

17,21-dihydroxy-pregn-4-ene-20-dione

17-hydroxy-11-deoxycorticosterone

nsc-18317

CORTODOXONE

CORTEXOLONE

17ALPHA,21-DIHYDROXY-4-PREGNENE-3,20-DIONE

17ALPHA,21-DIHYDROXYPREGNA-4-ENE-3,20-DIONE

11-DEOXY-17-HYDROXYCORTICOSTERONE

11-DEOXYCORTISOL

11-DESOXY-17-HYDROXYCORTICOSTERONE

11-DESOXYCORTISOL

Reichstein S

11-Deoxy-17-hydroxycorticosterone, 11-Deoxycortisol, 17α,21-Dihydroxy-4-pregnene-3,20-dione, 17α-Hydroxycortexone, 17,21-Dihydroxy-4-pregnene-3,20-dione, 17,21-Dihydroxyprogesterone, 4-Pregnene-17α,21-diol-3,20-dione, Cortexolone, Reichsteins Compound S

ReichsteinSubstanceS

17α,21-Dihydroxypregn-4-ene-3,20-dione

Cortexolone,99%

Reichstein’s substanceS,11-Deoxy-17-hydroxycorticosterone, 11-Deoxycortisol, 17α,21-Dihydroxy-4-pregnene-3,20-dione, 17α-Hydroxycortexone, 17,21-Dihydroxy-4-pregnene-3,20-dione, 17,21-Dihydroxyproges

11-Deoxy-17-hydroxycorticosterone 17alpha,21-Dihydroxy-4-pregnene-3,20-dione Reichstein's Substance S

4-Pregnen-17a,21-diol-3,20-dione-d2

Pregn-4-ene-3,20-dione, 17,21-dihydroxy-

11-Deoxycortisol solution

cortexolone solution,100ppm

17α-Hydroxycortexone

4-Pregnene-17α,21-diol-3,20-dione

Hydrocortisone impurity F (EP)

Hydrocortisone EP Impurity F

11-deoxyhydrocortisone

11-desoxyhydrocortisone

17ALPHA-HYDROXYCORTEXONE

17,21-DIHYDROXY-4-PREGNENE-3,20-DIONE

17,21-DIHYDROXYPROGESTERONE

4-PREGNENE-17ALPHA,21-DIOL-3,20-DIONE

4-PREGNEN-17,21-DIOL-3,20-DIONE

4-PREGNEN-17A 21-DIOL-3,20-DIONE

4-PREGNEN-17ALPHA,21-DIOL-3,20-DIONE

(8R,9S,10R,13S,14S,17R)-17-HYDROXY-17-(2-HYDROXY-ACETYL)-10,13-DIMETHYL-1,2,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE

REICHSTEIN'S COMPOUND ''S''

REICHSTEIN'S SUBSTANCE S

REICHSTEIN'S SUBSTANCE ''S''

REICHSTEIN'S SUBSTANCE 'S'

skf3050

11-Desoxycortisone

17alpha,21-Dihydroxypregn-4-ene-3,20-dione

17,21-Dihydroxypregn-4-en-3,20-dione

4-Pregnene-17a,21-diol-3,20-dione

17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one

Deoxycortisol

Cortexolone &gt

17,21-Dihydroxypregn-4-ene-3,20-dio

Hydrocortisone EP Impurity F (Reichsteins Substance S)

(8R,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-

152-58-9 CORTEXOLONE

17α,21-dihydroxyprogesterone