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CORTISONE

Product Name
CORTISONE
CAS No.
53-06-5
Chemical Name
CORTISONE
Synonyms
KE;Corlin;Corton;Adreson;CORTONE;Andreson;Cortisal;Cortison;Cortogen;Incortin
CBNumber
CB6413305
Molecular Formula
C21H28O5
Formula Weight
360.44
MOL File
53-06-5.mol
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CORTISONE Property

Melting point:
223-228 °C (dec.)(lit.)
alpha 
D25 +209° (c = 1.2 in 95% alcohol); 25546 +269° (c = 0.125 in benzene); 25546 +248° (c = 0.1 to 0.2 in alcohol)
Boiling point:
412.46°C (rough estimate)
Density 
1.28±0.1 g/cm3 (20 ºC 760 Torr)
refractive index 
210 ° (C=1, EtOH)
Flash point:
9℃
storage temp. 
-20°C Freezer
pka
12.37±0.60(Predicted)
Water Solubility 
229.9mg/L(25 ºC)
Merck 
2539
CAS DataBase Reference
53-06-5(CAS DataBase Reference)
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Safety

Hazard Codes 
F,T,Xn
Risk Statements 
11-23/24/25-39/23/24/25-63
Safety Statements 
22-24/25-45-36/37-16-7
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
3
RTECS 
GM9020000
18
HS Code 
2937210000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H370Causes damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P311Call a POISON CENTER or doctor/physician.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C-130
Product name
Cortisone solution
Purity
100 μg/mL in methanol, ampule of 1 mL, certified reference material
Packaging
130-1ml
Price
$53.5
Updated
2020/08/18
Alfa Aesar
Product number
J64182
Product name
Cortisone
Packaging
5g
Price
$153
Updated
2021/03/22
Alfa Aesar
Product number
J64182
Product name
Cortisone
Packaging
1g
Price
$48.3
Updated
2021/03/22
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CORTISONE Chemical Properties,Usage,Production

Chemical Properties

Off-White Crystalline Powder

Originator

Cortone Acetate,MSD,US,1950

Uses

Cortisone is used for inflammatory processes, allergies, and adrenal insufficiency.

Uses

Glucocorticoid, anti-inflammatory agent

Uses

antiinflammatory, glucocorticoid

Uses

Anticoagulant

Definition

ChEBI: A C21-steroid that is pregn-4-ene substituted by hydroxy groups at positions 17 and 21 and oxo group at positions 3, 11 and 20.

Manufacturing Process

The following technique is described in US Patent 2,541,104. A solution of 2.0 g of 3(α)-hydroxy-21-acetoxy-11,20-diketo-pregnane, which can be prepared as described in Helv. Chim. Acta 27, 1287 (1944), is treated in a mixture of 25 cc of alcohol and 6.4 cc of acetic acid at 0°C with 6.0 g of potassium
cyanide. The solution is allowed to warm to room temperature and after 3 hours is diluted with water. The addition of a large volume of water to the alcohol-hydrogen cyanide mixture precipitates a gum which is extracted with chloroform or ethyl acetate. The extract is washed with water, and evaporated to small volume under reduced pressure. The crystalline precipitate (1.3 g) consists of 3(α),20-dihydroxy-20-cyano-21-acetoxy-11-keto-pregnane; dec. 175° to 185°C.
A solution of 0.60 g of chromic acid in 1.2 cc of water and 11 cc of acetic acid is added to a solution containing about 1.2 g of 3(α),20-dihydroxy-20-cyano- 21-acetoxy-11-ketopregnane at room temperature. After 1 hour, water is added and the product, which precipitates, is filtered and recrystallized from ethyl acetate to produce 3,11-diketo-20-hydroxy-20-cyano-21-acetoxypregnane; dec. 214° to 217°C.
0.40 cc of phosphorus oxychloride is added to a solution containing about 950 mg of 3,11-diketo-20-hydroxy-20-cyano-21-acetoxy-pregnane dissolved in 3 cc of pyridine. After standing at room temperature for 24 hours, the solution is poured into water and dilute hydrochloric acid, extracted with benzene and concentrated to dryness. The crude product, after chromatography gives one main constituent, namely δ17-3,11-diketo-20-cyano-21-acetoxy-pregnene; MP 189° to 190°C.
A solution of 1.0 g of δ17-3,11-diketo-20-cyano-21-acetoxy-pregnene in 10 cc of benzene is treated with 1.0 g of osmium tetroxide and 0.43 g of pyridine. After standing at room temperature for 18 hours, the resulting solution is treated successively with 50 cc of alcohol, and with 50 cc of water containing 2.5 g of sodium sulfite. The mixture is stirred for 30 hours, filtered, and the filtrate acidified with 0.5 cc of acetic acid and concentrated to small volume in vacuo. The aqueous suspension is then extracted four times with chloroform, the chloroform extracts are combined, washed with water and concentrated to dryness in vacuo. Recrystallization of the residue from acetone gives 9°C. This compound is then treated with acetic anhydride and pyridine for 15 minutes at room temperature to produce 3,11,20-triketo-17(α)-hydroxy-21-acetoxypregnane or cortisone acetate.

Therapeutic Function

Glucocorticoid

Hazard

Damaging side effects, e.g., sodium retention from ingestion.

Pharmacokinetics

Following oral administration, cortisone acetate and hydrocortisone acetate are completely and rapidly deacetylated by first-pass metabolism. Much of the oral cortisone, however, is inactivated by oxidative metabolism before it can be converted to hydrocortisone in the liver. The pharmacokinetics for hydrocortisone acetate is indistinguishable from that of orally administered hydrocortisone. Oral hydrocortisone is completely absorbed, with a bioavailability of greater than 95% and a half-life of 1 to 2 hours (23).

Clinical Use

Cortisone is administered orally or by intramuscular (IM) injection as its 21-acetate (cortisone acetate).Cortisone acetate or hydrocortisone usually is the corticosteroid of choice for replacement therapy in patients with adrenocortical insufficiency, because these drugs have both glucocorticoid and mineralocorticoid properties.

Chemical Synthesis

Cortisone, 17α,21-dihydroxypregn-4-en-3,11,20-trione (27.1.26), is also synthesized in various ways from compounds already having the steroid skeleton. One of them is very similar to a method of making hydrocortisone described above, in which it is synthesized from progesterone, which undergoes microbiological oxidation, forming 11α-hydroxyprogesterone (27.1.9). The hydroxyl group of the last is oxidized by chromium(VI) oxide in acetic acid, giving 11-ketoprogesterone (27.1.10). This is reacted with diethyloxalate in the presence of sodium ethoxide, forming the corresponding α-ketoester in the form of a sodium enolate 27.1.11, which undergoes bromination with two equivalents of bromine, giving a dibromoketone 27.1.12. The resulting dibromoketone undergoes a Favorskii rearrangement, but the product is not hydrolyzed, and the unsaturated acid is isolated in the form of a methyl ester 27.1.20. Reacting this with pyrrolidine gives a dienamine 27.1.21, which undergoes reduction by lithium aluminum hydride, which results in that, the keto-group on C11 transforms into a hydroxyl group, and the carbmethoxy group to a primary alcohol, forming the compound 27.1.22. Acidic hydrolysis of the product and subsequent acetylation gives an acetate 27.1.23, and the hydroxyl group at C11 in which it is oxidized with chromium(VI) oxide to a ketone, forming the compound 27.1.24. This undergoes a reaction with osmium tetroxide, and the resulting osmate is oxidized by magnesium dioxide in N-methylmorpholine, giving cortisone acetate 27.1.25. Hydrolysis of the acetyl group using sodium bicarbonate leads to the formation of cortisone (27.1.26).

Metabolism

The metabolism of hydrocortisone has been previously described. Cortisone acetate is slowly absorbed from IM injection sites over a period of 24 to 48 hours and is reserved for patients who are unable to take the drug orally. The acetate ester derivative demonstrates increased stability and has a longer duration of action when administered by IM injection. Thus, smaller doses can be used. Similarly, hydrocortisone may be dispensed as its 21-acetate (hydrocortisone acetate), which is superior to cortisone acetate when injected intra-articularly.

Purification Methods

Crystallise cortisone from 95% EtOH or acetone. The UV has 14,000 M-1cm -1 at 237nm (EtOH). [Beilstein 8 IV 3480, Hems J Pharm Pharmacol 5 409 1953, Beilstein 8 IV 3480.]

CORTISONE Preparation Products And Raw materials

Raw materials

Preparation Products

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CORTISONE Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96500
Advantage
76
Hangzhou Zyter Biological & Chemical Technology Co., Ltd.
Tel
0086-18858184290
Fax
0086-571-28313105
Email
sales@zyterpharm.com
Country
China
ProdList
49
Advantage
49
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15877
Advantage
69
Nanjing Chemlin Chemical Co., Ltd
Tel
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
20007
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32358
Advantage
50
Syntechem Co.,Ltd
Tel
Please Email
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
13009
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14457
Advantage
57
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847-
Fax
021-55068248
Email
3008007399@qq.com
Country
China
ProdList
4995
Advantage
60
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
028-85911938-
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9750
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
86-21-58998985
Fax
(86) 21-58955996
Email
apisales@chemexpress.com.cn
Country
China
ProdList
7557
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View Lastest Price from CORTISONE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Andreson 53-06-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Dideu Industries Group Limited
Product
CORTISONE USP/EP/BP 53-06-5
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-06-11
Career Henan Chemical Co
Product
CORTISONE 53-06-5
Price
US $1.00/KG
Min. Order
1KG
Purity
98% HPLC
Supply Ability
10 tons/month
Release date
2020-01-09

53-06-5, CORTISONERelated Search:


  • 17,21-Dihydroxy-4-pregnene-3,11,20-trione
  • 17,21-Dihydroxypregn-4-ene-3,11,20-trione
  • 20-trione,17,21-dihydroxy-pregn-4-ene-11
  • Adrenalex
  • Adreson
  • Andreson
  • Corlin
  • Cortadren
  • Cortandren
  • Cortisal
  • Cortisate
  • Cortison
  • Cortistal
  • Cortivite
  • Cortogen
  • delta(sup4)-pregnene-17alpha,21-diol-3,11,20-trione
  • Incortin
  • KE
  • Kendall's compound
  • Pregn-4-en-17alpha,21-diol-3,11,20-trione
  • Pregn-4-ene-3,11,20-trione, 17,21-dihydroxy-
  • Reichstein Fa
  • Scheroson
  • (8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-diMethyl-7,8,9,10,12,13,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthrene-3,11(2H,6H)-dione
  • Cortisone solution
  • Cortisone-[2H7]
  • NSC 9703
  • 4-Pregnen-17a,21-diol-3,11,20-trione-d2
  • 11-DEHYDRO-17-HYDROXYCORTICOSTERONE
  • 17A 21-DIHYDROXY-4-PREGNEN-3 17 20-TRIONE
  • 17ALPHA,21-DIHYDROXYPREGN-4-ENE-3,11,20-TRIONE
  • 17ALPHA,21-DIHYDROXY-4-PREGNENE-3,11,20-TRIONE
  • 17ALPHA-HYDROXY-11-DEHYDROCORTICOSTERONE
  • 17-HYDROXY-11-DEHYDROCORTICOSTERONE
  • 4-PREGNENE-17ALPHA,21-DIOL-3,11,20-TRIONE
  • 4-PREGNEN-17ALPHA,21-DIOL-3,11,20-TRIONE
  • 4-PREGNEN-17,21-DIOL-3,11,20-TRIONE
  • 4-PREGEN-17A,21-DIOL-3,11,20-TRIONE
  • KENDALL'S CMPD ''E''
  • KENDALL'S ''E''
  • 4-Pregnene-17α,21-diol-3,11,20-trione
  • (8S,9S,10R,13S,14S,17R)-17-glycoloyl-17-hydroxy-10,13-dimethyl-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,11-quinone
  • (8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyethanoyl)-10,13-dimethyl-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,11-dione
  • Hydrocortisone EP Impurity B
  • (8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxy-1-oxoethyl)-10,13-dimethyl-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,11-dione
  • (8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyethanoyl)-10,13-dimethyl-1,2,6,7,8,9,12
  • Cortisone solution,100ppm
  • Hydrocortisone impurity B (EP)
  • KENDALL'S COMPOUND E
  • KENDALL'S COMPOUND 'E'
  • CORTONE
  • CORTISONE
  • DELTA4-PREGNENE-17, 21-DIOL-3, 11, 20-TRIONE
  • DELTA4-PREGNENE-17ALPHA,21-DIOL-3,11,20-TRIONE
  • DELTA-PREGNENE-17ALPHA,21-DIOL-3,11,20-TRIONE
  • REICHSTEIN'S SUBSTANCE FA
  • REICHSTEIN'S SUBSTANCE 'FA'
  • REICHSTEIN'S COMPOUND ''FA''