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Cortisone acetate

Product Name
Cortisone acetate
CAS No.
50-04-4
Chemical Name
Cortisone acetate
Synonyms
artriona;cortelan;cortisyl;ricortex;NSC 49420;cortistab;biocortacetate;cortoneacetate;irisoneacetate;cortogenacetate
CBNumber
CB9277612
Molecular Formula
C23H30O6
Formula Weight
402.48
MOL File
50-04-4.mol
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Cortisone acetate Property

Melting point:
237-240 °C(lit.)
alpha 
D25 +164° (c = 0.5 in acetone); D25 +208 to +217° (dioxane)
Boiling point:
577.3±50.0 °C(Predicted)
Density 
1.26±0.1 g/cm3(Predicted)
refractive index 
212 ° (C=1, MeOH)
storage temp. 
2-8°C
solubility 
Practically insoluble in water, freely soluble in methylene chloride, soluble in dioxan, sparingly soluble in acetone, slightly soluble in ethanol (96 per cent) and in methanol.
form 
neat
pka
12.32±0.60(Predicted)
Water Solubility 
19mg/L(25 ºC)
Merck 
14,2539
BRN 
2067543
Stability:
Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference
50-04-4(CAS DataBase Reference)
EPA Substance Registry System
Cortisone acetate (50-04-4)
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Safety

Safety Statements 
22-36/37-24/25
WGK Germany 
3
RTECS 
GM9140000
HS Code 
32041200
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C2800000
Product name
Cortisone acetate
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
c2800000
Price
$190
Updated
2020/08/18
Sigma-Aldrich
Product number
C2800000
Product name
Cortisone acetate
Purity
European Pharmacopoeia (EP) Reference Standard
Price
$190
Updated
2021/03/22
Sigma-Aldrich
Product number
BP585
Product name
Cortisone acetate
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
bp585
Price
$196
Updated
2020/08/18
Sigma-Aldrich
Product number
BP585
Product name
Cortisone acetate
Purity
British Pharmacopoeia (BP) Reference Standard
Price
$196
Updated
2021/03/22
Cayman Chemical
Product number
23798
Product name
Cortisone Acetate
Purity
≥98%
Packaging
5g
Price
$49
Updated
2021/03/22
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Cortisone acetate Chemical Properties,Usage,Production

Chemical Properties

solid

Originator

Cortone Acetate,MSD,US,1950

Uses

Cortisone Acetate is a glucocorticoid. Cortisone Acetate is an antiinflammatory agent. Cortisone Acetate is bioavailable and readily converted to the therapeutically active form, Hydrocotisone (H71461 5).

Manufacturing Process

The following technique is described in US Patent 2,541,104. A solution of 2.0 g of 3(α)-hydroxy-21-acetoxy-11,20-diketo-pregnane, which can be prepared as described in Helv. Chim. Acta 27, 1287 (1944), is treated in a mixture of 25 cc of alcohol and 6.4 cc of acetic acid at 0°C with 6.0 g of potassium
cyanide. The solution is allowed to warm to room temperature and after 3 hours is diluted with water. The addition of a large volume of water to the alcohol-hydrogen cyanide mixture precipitates a gum which is extracted with chloroform or ethyl acetate. The extract is washed with water, and evaporated to small volume under reduced pressure. The crystalline precipitate (1.3 g) consists of 3(α),20-dihydroxy-20-cyano-21-acetoxy-11-keto-pregnane; dec. 175° to 185°C.
A solution of 0.60 g of chromic acid in 1.2 cc of water and 11 cc of acetic acid is added to a solution containing about 1.2 g of 3(α),20-dihydroxy-20-cyano- 21-acetoxy-11-ketopregnane at room temperature. After 1 hour, water is added and the product, which precipitates, is filtered and recrystallized from ethyl acetate to produce 3,11-diketo-20-hydroxy-20-cyano-21-acetoxypregnane; dec. 214° to 217°C.
0.40 cc of phosphorus oxychloride is added to a solution containing about 950 mg of 3,11-diketo-20-hydroxy-20-cyano-21-acetoxy-pregnane dissolved in 3 cc of pyridine. After standing at room temperature for 24 hours, the solution is poured into water and dilute hydrochloric acid, extracted with benzene and concentrated to dryness. The crude product, after chromatography gives one main constituent, namely δ17-3,11-diketo-20-cyano-21-acetoxy-pregnene; MP 189° to 190°C.
A solution of 1.0 g of δ17-3,11-diketo-20-cyano-21-acetoxy-pregnene in 10 cc of benzene is treated with 1.0 g of osmium tetroxide and 0.43 g of pyridine. After standing at room temperature for 18 hours, the resulting solution is treated successively with 50 cc of alcohol, and with 50 cc of water containing 2.5 g of sodium sulfite. The mixture is stirred for 30 hours, filtered, and the filtrate acidified with 0.5 cc of acetic acid and concentrated to small volume in vacuo. The aqueous suspension is then extracted four times with chloroform, the chloroform extracts are combined, washed with water and concentrated to dryness in vacuo. Recrystallization of the residue from acetone gives 9°C. This compound is then treated with acetic anhydride and pyridine for 15 minutes at room temperature to produce 3,11,20-triketo-17(α)-hydroxy-21-acetoxypregnane or cortisone acetate.

Therapeutic Function

Glucocorticoid

General Description

Cortisone acetate, 21-(acetyloxy)-17-hydroxypregn-4-ene-3,11,20-trione, is the 21-acetate of naturally occurring cortisone with good systemicanti-inflammatory activity and low-to-moderate salt-retentionactivity after its in vivo conversion to hydrocortisoneacetate. This conversion is mediated by 11β-hydroxysteroiddehydrogenase. It is used for the entire spectrum of uses discussedpreviously under the heading, “Therapeutic Uses ofAdrenal Cortex Hormones”—collagen diseases, Addisondisease, severe shock, allergic conditions, chronic lymphocyticleukemia, and many other indications. Cortisone acetateis relatively ineffective topically, mainly because itmust be reduced in vivo to hydrocortisone. Its plasma halflifeis only about 30 minutes, compared with 90 minutes to3 hours for hydrocortisone.

Purification Methods

Crystallise -1cortisone-21-acetate from acetone or CHCl3. The UV has 15,800 M-1cm at 238nm in dioxane. [Sarett J Biol Chem 162 601 1946, Beilstein 8 III 4058, 5 IV 3481.]

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Cortisone acetate Suppliers

Hubei Zhongshan Medical Technology Co., Ltd
Tel
027-61907345-
Email
w13397111514@163.com
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China
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J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
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86-10-82849933
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jkinfo@jkchemical.com;market6@jkchemical.com
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China
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Meryer (Shanghai) Chemical Technology Co., Ltd.
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21-61259100-
Fax
86-21-61259102
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sh@meryer.com
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China
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40264
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BeiJing Hwrk Chemicals Limted
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0757-86329057-
Fax
0757-86311057
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sales.gd@hwrkchemical.com
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China
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17295
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Energy Chemical
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021-58432009-
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021-58436166
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sales8178@energy-chemical.com
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China
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Beijing Ouhe Technology Co., Ltd
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010-82967028-
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+86-10-82967029
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2355560935@qq.com
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China
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Chemsky(shanghai)International Co.,Ltd.
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021-50135380
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shchemsky@sina.com
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32358
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XiaoGan ShenYuan ChemPharm co,ltd
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0712-2580635- ;0712-2580635
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1791901229@qq.com;1791901229@qq.com;
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China
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Syntechem Co.,Ltd
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Please Email
Fax
E-Mail Inquiry
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China
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BEST-REAGENT
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400-1166-196;028-84555506- ;028-84555506-
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China
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View Lastest Price from Cortisone acetate manufacturers

Wuhan Dujiang Industrial Co., Ltd.
Product
Cortisone acetate 50-04-4
Price
US $66.00/KG
Min. Order
1KG
Purity
Above95%
Supply Ability
Weekly supply of 100KG
Release date
2021-11-03
Wuhan Dujiang Industrial Co., Ltd.
Product
Cortisone acetate 50-04-4
Price
US $66.00/KG
Min. Order
1KG
Purity
Above96%
Supply Ability
Weekly supply of 100KG
Release date
2021-11-02
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Cortisone acetate 50-04-4
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
100kg
Release date
2021-08-19

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