5-Bromo-2,3-difluorophenol
Uses- Product Name
- 5-Bromo-2,3-difluorophenol
- CAS No.
- 186590-26-1
- Chemical Name
- 5-Bromo-2,3-difluorophenol
- Synonyms
- 17-diol;LANACORT;17-Alpha;-diol-d3;-estran-3-one;A-NOR-5α-OL-3, 20-DIONE;9-Bromo-16α-DIOL 3-BENZOATE;-Dihydro-17&beta
- CBNumber
- CB5163700
- Molecular Formula
- C6H3BrF2O
- Formula Weight
- 208.99
- MOL File
- 186590-26-1.mol
5-Bromo-2,3-difluorophenol Property
- Melting point:
- 223 °C (dec.)(lit.)
- Boiling point:
- 65-66°C/0.1mm
- Density
- 1.858±0.06 g/cm3(Predicted)
- refractive index
- 1.538
- storage temp.
- Inert atmosphere,Room Temperature
- form
- clear liquid
- pka
- 6.75±0.15(Predicted)
- color
- White to Yellow to Green
- BRN
- 8831044
- CAS DataBase Reference
- 186590-26-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,T,Xi
- Risk Statements
- 63-36/37/38
- Safety Statements
- 36/37-26
- WGK Germany
- 3
- RTECS
- GM8960000
- Hazard Note
- Toxic
- HazardClass
- IRRITANT
- HS Code
- 2908190090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B4490
- Product name
- 5-Bromo-2,3-difluorophenol
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $49
- Updated
- 2026/03/19
- Product number
- B4490
- Product name
- 5-Bromo-2,3-difluorophenol
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $144
- Updated
- 2026/03/19
- Product number
- B691283
- Product name
- 5-Bromo-2,3-difluorophenol
- Packaging
- 5g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- B691283
- Product name
- 5-Bromo-2,3-difluorophenol
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 001203
- Product name
- 5-Bromo-2,3-difluorophenol
- Purity
- 97%
- Packaging
- 25g
- Price
- $37
- Updated
- 2021/12/16
5-Bromo-2,3-difluorophenol Chemical Properties,Usage,Production
Uses
5-Bromo-2,3-difluorophenol is an important intermediate in the synthesis of a large number of compounds with physiological or pharmacological activity. This compound can also be used to synthesize agrochemicals and liquid crystal compounds, and its applications are becoming increasingly widespread.
Chemical Properties
Colorless transparent liquid
Synthesis
(1) To a 1000 mL four-necked reaction flask equipped with a magnet and a reflux condenser tube was added 84.4 g of 3,4,5- trifluorobromobenzene (0.4 mol), 500 mL of methanol and 67.2 g of KOH (1.2 mol), the temperature was raised to 60 C after the addition was completed, and the reaction was stirred for 6 h. A gas chromatograph tracked the reaction process until the raw materials were basically reacted. After the reaction, the reaction solution was frozen at -10 for 5h, a large number of crystals were precipitated, and 80.0g of crystals were obtained by filtration and separation, and the content of the crystals in 2,3-difluoro-5-bromoanisole was 99.2% by GC normalization method. Methanol recovery can be used again.
(2) In a 1000 mL four-necked reaction flask equipped with a magnet and a reflux condenser tube, 80.0 g of obtained above was added. 2,3-difluoro-5-bromoanisole (0.36 mol), 600 mL of toluene and 71.8 g of AlCl3 (0.54 mol). The reaction was heated to 80 C under nitrogen protection and stirred for 5 h. Gas chromatography tracked the progress of the reaction until 2,3-difluoro-5-bromoanisole was essentially reacted. At the end of the reaction, the reaction solution was washed with water, the upper layer was separated, toluene was removed by spin distillation, and 5-bromo-2,3-difluorophenol was obtained by distillation under reduced pressure as 67.7 g, . The content of the product was 99.3% by GC analysis. Recovered toluene can be used again after drying treatment.
The nuclear magnetic spectra and mass spectra of the obtained target product were tested to be consistent with those of the standard, and the total yield of the two-step reaction was 81.0%.
5-Bromo-2,3-difluorophenol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Bromo-2,3-difluorophenol manufacturers
- Product
- 5-Bromo-2,3-difluorophenol 186590-26-1
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 2000kg
- Release date
- 2023-07-12
- Product
- 5-Bromo-2,3-difluorophenol 186590-26-1
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customise
- Release date
- 2018-08-09