2,3-Difluorophenol
- Product Name
- 2,3-Difluorophenol
- CAS No.
- 6418-38-8
- Chemical Name
- 2,3-Difluorophenol
- Synonyms
- Difluorophenol;3-Difluorophenol;2,3-DIFLUOROPHENOL;2,3-Difluorophenole;PHENOL, 2,3-DIFLUORO-;2,3-Difluorophenol>2,3-Difluorophenol 98%;2,3-Difluorophenol,98+%;2,3-Difluorophenol ,99%;2,3- twodifluoro phenol
- CBNumber
- CB5172968
- Molecular Formula
- C6H4F2O
- Formula Weight
- 130.09
- MOL File
- 6418-38-8.mol
2,3-Difluorophenol Property
- Melting point:
- 39-42 °C (lit.)
- Boiling point:
- 54 °C/25 mmHg (lit.)
- Density
- 1.2483 (estimate)
- Flash point:
- 134 °F
- storage temp.
- Inert atmosphere,2-8°C
- pka
- 7.71±0.10(Predicted)
- form
- powder to lump to clear liquid
- color
- White or Colorless to Almost white or Almost colorless
- BRN
- 2082265
- InChI
- InChI=1S/C6H4F2O/c7-4-2-1-3-5(9)6(4)8/h1-3,9H
- InChIKey
- RPEPGIOVXBBUMJ-UHFFFAOYSA-N
- SMILES
- C1(O)=CC=CC(F)=C1F
- CAS DataBase Reference
- 6418-38-8(CAS DataBase Reference)
Safety
- Hazard Codes
- F,Xn,Xi,C
- Risk Statements
- 11-22-36/37/38-34-20/21/22
- Safety Statements
- 26-45-36/37/39-16
- RIDADR
- UN 1325 4.1/PG 2
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- 4.1
- PackingGroup
- III
- HS Code
- 29081000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 265322
- Product name
- 2,3-Difluorophenol
- Purity
- 98%
- Packaging
- 5g
- Price
- $54.4
- Updated
- 2025/07/31
- Product number
- D2453
- Product name
- 2,3-Difluorophenol
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $35
- Updated
- 2025/07/31
- Product number
- D2453
- Product name
- 2,3-Difluorophenol
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $151
- Updated
- 2025/07/31
- Product number
- D473448
- Product name
- 2,3-Difluorophenol
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- JK193978
- Product name
- 2,3-Difluorophenol
- Purity
- 99%
- Packaging
- 5g
- Price
- $75
- Updated
- 2021/12/16
2,3-Difluorophenol Chemical Properties,Usage,Production
Chemical Properties
white crystalline low melting mass
Uses
Intermediates of Liquid Crystals
Application
2,3-Difluorophenol was used in the synthesis of material-poly{methyl[3-(2-hydroxy-3,4-difluoro)phenyl]propyl siloxane} (PMDFPS) sensitive to toxic organophosphate.
Synthesis
121219-16-7
6418-38-8
Step 1: In a 500 mL round-bottomed flask, dissolve 2,3-difluorophenylboronic acid (30 g, 189.98 mmol, 1.00 eq.) in dichloromethane (250 mL). Hydrogen peroxide (30 mL) was added slowly and dropwise under stirring conditions. The reaction mixture was stirred continuously at 25°C for 2 hours. Upon completion of the reaction, the reaction mixture was washed sequentially with water and saturated saline, the organic phase was dried over anhydrous magnesium sulfate, and subsequently concentrated under reduced pressure to afford 2,3-difluorophenol 23 g (93% yield) as a brown oil.
References
[1] K.P. RAJAPPAN NAIR . Supersonic jet microwave rotational spectrum of 2,3-difluorophenol[J]. Journal of Molecular Structure, 2019, 1195: Pages 479-484. DOI:10.1016/j.molstruc.2019.06.004.
[2] WEI HE . Analytical application of poly{methyl[3-(2-hydroxy-3,4-difluoro)phenyl]propyl siloxane} as a QCM coating for DMMP detection[J]. Talanta, 2008, 76 3: Pages 698-702. DOI:10.1016/j.talanta.2008.04.022.
[3] E. MARZI M. S J Gorecka. The regioexhaustive functionalization of difluorophenols and trifluorophenols through organometallic intermediates[J]. Synthesis-Stuttgart, 2004, 441 1: 1609-1618. DOI:10.1055/S-2004-829110.
2,3-Difluorophenol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,3-Difluorophenol manufacturers
- Product
- 2,3-Difluorophenol 6418-38-8
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-05
- Product
- 2,3-Difluorophenol 6418-38-8
- Price
- US $35.00-1.20/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-17
- Product
- 2,3-Difluorophenol 6418-38-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11