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Pentafluorophenol

Description Reference
Product Name
Pentafluorophenol
CAS No.
771-61-9
Chemical Name
Pentafluorophenol
Synonyms
PFP;HOPFP;PFP-OH;C6F5OH;Pentafluorophe;SSI(R) Unions;PERFLUOROPHENOL;Pentaflurophenol;PENTAFLUORPHENOL;PENTAFLUOROPHENOL
CBNumber
CB0135306
Molecular Formula
C6HF5O
Formula Weight
184.06
MOL File
771-61-9.mol
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Pentafluorophenol Property

Melting point:
34-36 °C(lit.)
Boiling point:
143 °C(lit.)
Density 
1.757
refractive index 
1.4270
Flash point:
162 °F
storage temp. 
Store in dark!
pka
5.50±0.33(Predicted)
form 
Low Melting Crystalline Solid
color 
White to almost white
Specific Gravity
1.757
Water Solubility 
soluble
BRN 
1912584
Stability:
Stable. Incompatible with strong oxidizing agents, bases, acid chlorides, acid anhydrides.
InChIKey
XBNGYFFABRKICK-UHFFFAOYSA-N
CAS DataBase Reference
771-61-9(CAS DataBase Reference)
NIST Chemistry Reference
Phenol, pentafluoro-(771-61-9)
EPA Substance Registry System
Pentafluorophenol (771-61-9)
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Safety

Hazard Codes 
Xi,T,C,Xn
Risk Statements 
36/37/38-34-20/21/22-63-43-23/24/25-45-67-40
Safety Statements 
26-36-45-36/37/39-36/37-24/25-23-53
RIDADR 
2811
WGK Germany 
3
RTECS 
SM6680000
3
Hazard Note 
Toxic/Irritant
TSCA 
T
HazardClass 
8
PackingGroup 
III
HS Code 
29081000
Toxicity
LD50 scu-rat: 322 mg/kg IZSBAI 3,91,65
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H336May cause drowsiness or dizziness

H351Suspected of causing cancer

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P281Use personal protective equipment as required.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
103799
Product name
Pentafluorophenol
Purity
ReagentPlus , ≥99%
Packaging
5g
Price
$33.9
Updated
2020/08/18
Sigma-Aldrich
Product number
103799
Product name
Pentafluorophenol
Purity
ReagentPlus , ≥99%
Packaging
10g
Price
$62.6
Updated
2020/08/18
TCI Chemical
Product number
P0919
Product name
Pentafluorophenol
Purity
>98.0%(GC)(T)
Packaging
10g
Price
$40
Updated
2020/06/24
TCI Chemical
Product number
P0919
Product name
Pentafluorophenol
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$85
Updated
2020/06/24
Alfa Aesar
Product number
A15574
Product name
Pentafluorophenol, 99%
Packaging
25g
Price
$109
Updated
2020/06/24
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Pentafluorophenol Chemical Properties,Usage,Production

Description

Pentafluorophenol can be used for the preparation of penta-fluorophenyl esters for peptide synthesis. It is used in the preparation of pentafluorophenyl esters for peptide synthesis and vulcanized polymers. It is also used for peptide coupling and heterocyclic acid derivatives. It is involved in the preparation of pentafluorophenyl formate which acts as a formulating agent for amines and amino acids. It can be used for synthesizing novel reagents which can achieve highly diastereoselective acetal cleavage.

Reference

3. Ishihara, Kazuaki, N. Hanaki, and H. Yamamoto. "Highly diastereoselective acetal cleavages using novel reagents prepared from organoaluminum and pentafluorophenol" Cheminform 25.9(2010):no-no.

Chemical Properties

White solid

Uses

Used for the preparation of pentafluorophenyl esters for peptide synthesis

Synthesis Reference(s)

The Journal of Organic Chemistry, 54, p. 5502, 1989 DOI: 10.1021/jo00284a022

Safety Profile

scu-rat LD50:322 mg/kg IZSBAI 3,91,65

Purification Methods

It is a hygroscopic low melting solid not freely soluble in H2O. Purify it by distillation, preferably in a vacuum [Forbes et al. J Chem Soc 2019 1959, IR and pKa: Birchall & Haszeldine J Chem Soc 13 1959]. IRofafilmhas max 3600 (OH) and 1575 (fluoroaromatic breathing) cm-1 . The benzoyl derivative has m 74-75o, 3,4-dinitrobenzoyl derivative has m 107o, the tosylate has m 64-65o (from EtOH) and the K salt crystallises from Me2CO, m 242o(dec), with 1H2O-salt the m is 248o(dec) and the 2H2O-salt has m 245o(dec). [Beilstein 6 IV 782.]

Pentafluorophenol Preparation Products And Raw materials

Raw materials

Preparation Products

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Pentafluorophenol Suppliers

Qi-Chem Co., Ltd.
Tel
0411-88165951-
Fax
0411-87406949
Email
marketing@qi-chem.com
Country
China
ProdList
103
Advantage
58
Shanghai Harvest Chemical Industrial Co., Ltd.
Tel
21-31038972-
Fax
+86-21-51385350
Email
ammyzuo@harvest-chem.com;
Country
China
ProdList
2006
Advantage
64
Sinfachem Limited.
Tel
025-84683399
Email
sinfachem@foxmail.com,sinfachemltd@foxmail.com,info@sinfachem.com
Country
China
ProdList
303
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66099280-
Email
sales01@aikonchem.com
Country
China
ProdList
15469
Advantage
50
Shanghai Furui Fine Chemicals Co., Ltd.
Tel
021-36041048-
Fax
86-021-36041048
Email
13361903612@189.cn
Country
China
ProdList
19
Advantage
55
Nanjing jianuolin Photoelectric Technology Co., Ltd
Tel
Fax
025-83587982
Email
hangxiaochun@sina.com
Country
China
ProdList
231
Advantage
58
SHANG FLUORO
Tel
021-65170832- ;021-65170832-
Fax
021-65170832
Email
shangfluoro@hotmail.com;shangfluoro@hotmail.com
Country
China
ProdList
410
Advantage
60
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
PharmaBlock Sciences (Nanjing),Inc.
Fax
86-025-86918232
Email
sales@pharmablock.com
Country
China
ProdList
6446
Advantage
55
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40268
Advantage
62
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View Lastest Price from Pentafluorophenol manufacturers

Hebei Runbin Biotechnology Co. LTD
Product
Pentafluorophenol 771-61-9
Price
US $3.50/g
Min. Order
100g
Purity
99%
Supply Ability
5000 Kilogram/Kilograms per Month
Release date
2020-08-17
career henan chemical co
Product
Pentafluorophenol 771-61-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
Customized
Release date
2018-08-09

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