Pentafluorophenol
Description Reference- Product Name
- Pentafluorophenol
- CAS No.
- 771-61-9
- Chemical Name
- Pentafluorophenol
- Synonyms
- PFP;2,3,4,5,6-PENTAFLUOROPHENOL;HOPFP;PFP-OH;PENTAFLUORPHENOL;C6F5OH;Pentafluorophe;SSI(R) Unions;PERFLUOROPHENOL;Pentaflurophenol
- CBNumber
- CB0135306
- Molecular Formula
- C6HF5O
- Formula Weight
- 184.06
- MOL File
- 771-61-9.mol
Pentafluorophenol Property
- Melting point:
- 34-36 °C (lit.)
- Boiling point:
- 143 °C (lit.)
- Density
- 1.757
- refractive index
- 1.4270
- Flash point:
- 162 °F
- storage temp.
- Store below +30°C.
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Low Melting Crystalline Solid
- pka
- 5.50±0.33(Predicted)
- Specific Gravity
- 1.757
- color
- White to almost white
- Water Solubility
- soluble
- BRN
- 1912584
- Stability:
- Stable. Incompatible with strong oxidizing agents, bases, acid chlorides, acid anhydrides.
- InChIKey
- XBNGYFFABRKICK-UHFFFAOYSA-N
- CAS DataBase Reference
- 771-61-9(CAS DataBase Reference)
- NIST Chemistry Reference
- Phenol, pentafluoro-(771-61-9)
- EPA Substance Registry System
- Pentafluorophenol (771-61-9)
Safety
- Hazard Codes
- Xi,T,C,Xn
- Risk Statements
- 36/37/38-34-20/21/22-63-43-23/24/25-45-67-40
- Safety Statements
- 26-36-45-36/37/39-36/37-24/25-23-53
- RIDADR
- 2811
- WGK Germany
- 3
- RTECS
- SM6680000
- F
- 3
- Hazard Note
- Toxic/Irritant
- TSCA
- T
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29081000
- Toxicity
- LD50 scu-rat: 322 mg/kg IZSBAI 3,91,65
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- 103799
- Product name
- Pentafluorophenol
- Purity
- ReagentPlus , ≥99%
- Packaging
- 5g
- Price
- $42.5
- Updated
- 2024/03/01
- Product number
- 103799
- Product name
- Pentafluorophenol
- Purity
- ReagentPlus , ≥99%
- Packaging
- 10g
- Price
- $78.3
- Updated
- 2024/03/01
- Product number
- 8.18100
- Product name
- Pentafluorophenol
- Purity
- for synthesis
- Packaging
- 25g
- Price
- $162
- Updated
- 2022/05/15
- Product number
- P0919
- Product name
- Pentafluorophenol
- Purity
- >98.0%(GC)(T)
- Packaging
- 10g
- Price
- $50
- Updated
- 2024/03/01
- Product number
- P0919
- Product name
- Pentafluorophenol
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $103
- Updated
- 2024/03/01
Pentafluorophenol Chemical Properties,Usage,Production
Description
Pentafluorophenol can be used for the preparation of penta-fluorophenyl esters for peptide synthesis. It is used in the preparation of pentafluorophenyl esters for peptide synthesis and vulcanized polymers. It is also used for peptide coupling and heterocyclic acid derivatives. It is involved in the preparation of pentafluorophenyl formate which acts as a formulating agent for amines and amino acids. It can be used for synthesizing novel reagents which can achieve highly diastereoselective acetal cleavage.
Reference
3. Ishihara, Kazuaki, N. Hanaki, and H. Yamamoto. "Highly diastereoselective acetal cleavages using novel reagents prepared from organoaluminum and pentafluorophenol" Cheminform 25.9(2010):no-no.
Chemical Properties
White solid
Uses
Used for the preparation of pentafluorophenyl esters for peptide synthesis
Uses
Pentafluorophenol is used in the preparation of pentafluorophenyl esters for peptide synthesis and vulcanized polymers. It is also used for peptide coupling and heterocyclic acid derivatives. It is involved in the preparation of pentafluorophenyl formate which acts as a formulating agent for amines and amino acids.
Uses
For the preparation of pentafluorophenyl esters for peptide synthesis.
Application
Pentafluorophenol can be used as a reactant to synthesize pentafluorophenyl esters from:
- N-protected amino acid in the presence of dicyclohexylcarbodiimide and ethyl acetate.
- t-Butoxycarbonyl-L-alanylglycinein the presence of 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride.
- Aliphatic dicarboxylic acids in the presence of pyridine, diisopropylcarbodiimide, and acetonitrile.
Synthesis Reference(s)
The Journal of Organic Chemistry, 54, p. 5502, 1989 DOI: 10.1021/jo00284a022
General Description
Pentafluorophenol is widely used as a precursor in both solution and solid-phase peptide synthesis. It is also involved in the preparation of aromatic fluoro derivatives.
Safety Profile
scu-rat LD50:322 mg/kg IZSBAI 3,91,65
Purification Methods
Pentafluorophenol is a hygroscopic low melting solid not freely soluble in H2O. Purify it by distillation, preferably in a vacuum [Forbes et al. J Chem Soc 2019 1959, IR and pKa: Birchall & Haszeldine J Chem Soc 13 1959]. IRofafilmhas max 3600 (OH) and 1575 (fluoroaromatic breathing) cm-1 . The benzoyl derivative has m 74-75o, 3,4-dinitrobenzoyl derivative has m 107o, the tosylate has m 64-65o (from EtOH) and the K salt crystallises from Me2CO, m 242o(dec), with 1H2O-salt the m is 248o(dec) and the 2H2O-salt has m 245o(dec). [Beilstein 6 IV 782.]
Pentafluorophenol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Pentafluorophenol manufacturers
- Product
- Pentafluorophenol 771-61-9
- Price
- US $0.00-0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500kg/month
- Release date
- 2021-08-17
- Product
- Pentafluorophenol 771-61-9
- Price
- US $6.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10000
- Release date
- 2024-08-08
- Product
- Pentafluorophenol 771-61-9
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2021-08-19