ChemicalBook > CAS DataBase List > 2,3-Difluorophenol

2,3-Difluorophenol

Product Name
2,3-Difluorophenol
CAS No.
6418-38-8
Chemical Name
2,3-Difluorophenol
Synonyms
Difluorophenol;3-Difluorophenol;2,3-DIFLUOROPHENOL;2,3-Difluorophenole;PHENOL, 2,3-DIFLUORO-;2,3-Difluorophenol>2,3-Difluorophenol 98%;2,3-Difluorophenol,98+%;2,3-Difluorophenol ,99%;2,3- twodifluoro phenol
CBNumber
CB5172968
Molecular Formula
C6H4F2O
Formula Weight
130.09
MOL File
6418-38-8.mol
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2,3-Difluorophenol Property

Melting point:
39-42 °C (lit.)
Boiling point:
54 °C/25 mmHg (lit.)
Density 
1.2483 (estimate)
Flash point:
134 °F
storage temp. 
Inert atmosphere,2-8°C
pka
7.71±0.10(Predicted)
form 
powder to lump to clear liquid
color 
White or Colorless to Almost white or Almost colorless
BRN 
2082265
InChI
InChI=1S/C6H4F2O/c7-4-2-1-3-5(9)6(4)8/h1-3,9H
InChIKey
RPEPGIOVXBBUMJ-UHFFFAOYSA-N
SMILES
C1(O)=CC=CC(F)=C1F
CAS DataBase Reference
6418-38-8(CAS DataBase Reference)
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Safety

Hazard Codes 
F,Xn,Xi,C
Risk Statements 
11-22-36/37/38-34-20/21/22
Safety Statements 
26-45-36/37/39-16
RIDADR 
UN 1325 4.1/PG 2
WGK Germany 
3
Hazard Note 
Irritant
HazardClass 
4.1
PackingGroup 
III
HS Code 
29081000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H226Flammable liquid and vapour

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
265322
Product name
2,3-Difluorophenol
Purity
98%
Packaging
5g
Price
$54.4
Updated
2025/07/31
TCI Chemical
Product number
D2453
Product name
2,3-Difluorophenol
Purity
>98.0%(GC)
Packaging
5g
Price
$35
Updated
2025/07/31
TCI Chemical
Product number
D2453
Product name
2,3-Difluorophenol
Purity
>98.0%(GC)
Packaging
25g
Price
$151
Updated
2025/07/31
TRC
Product number
D473448
Product name
2,3-Difluorophenol
Packaging
100mg
Price
$60
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK193978
Product name
2,3-Difluorophenol
Purity
99%
Packaging
5g
Price
$75
Updated
2021/12/16
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2,3-Difluorophenol Chemical Properties,Usage,Production

Chemical Properties

white crystalline low melting mass

Uses

Intermediates of Liquid Crystals

Application

2,3-Difluorophenol was used in the synthesis of material-poly{methyl[3-(2-hydroxy-3,4-difluoro)phenyl]propyl siloxane} (PMDFPS) sensitive to toxic organophosphate.

Synthesis

121219-16-7

6418-38-8

Step 1: In a 500 mL round-bottomed flask, dissolve 2,3-difluorophenylboronic acid (30 g, 189.98 mmol, 1.00 eq.) in dichloromethane (250 mL). Hydrogen peroxide (30 mL) was added slowly and dropwise under stirring conditions. The reaction mixture was stirred continuously at 25°C for 2 hours. Upon completion of the reaction, the reaction mixture was washed sequentially with water and saturated saline, the organic phase was dried over anhydrous magnesium sulfate, and subsequently concentrated under reduced pressure to afford 2,3-difluorophenol 23 g (93% yield) as a brown oil.

References

[1] K.P. RAJAPPAN NAIR . Supersonic jet microwave rotational spectrum of 2,3-difluorophenol[J]. Journal of Molecular Structure, 2019, 1195: Pages 479-484. DOI:10.1016/j.molstruc.2019.06.004.
[2] WEI HE . Analytical application of poly{methyl[3-(2-hydroxy-3,4-difluoro)phenyl]propyl siloxane} as a QCM coating for DMMP detection[J]. Talanta, 2008, 76 3: Pages 698-702. DOI:10.1016/j.talanta.2008.04.022.
[3] E. MARZI M. S J Gorecka. The regioexhaustive functionalization of difluorophenols and trifluorophenols through organometallic intermediates[J]. Synthesis-Stuttgart, 2004, 441 1: 1609-1618. DOI:10.1055/S-2004-829110.

2,3-Difluorophenol Preparation Products And Raw materials

Raw materials

Preparation Products

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2,3-Difluorophenol Suppliers

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View Lastest Price from 2,3-Difluorophenol manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
2,3-Difluorophenol 6418-38-8
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 mt
Release date
2024-11-05
Henan Fengda Chemical Co., Ltd
Product
2,3-Difluorophenol 6418-38-8
Price
US $35.00-1.20/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-17
Zhuozhou Wenxi import and Export Co., Ltd
Product
2,3-Difluorophenol 6418-38-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11

6418-38-8, 2,3-Difluorophenol Related Search:

4-Fluorophenol Xylenol 1,3-Difluorobenzene 2-Phenylphenol 4-Trifluoromethylphenol 3,4-DIFLUOROPHENOL 3,5-DIFLUOROPHENOL 2,6-DIFLUOROPHENOL 6-NITRO-2,3-DIFLUOROPHENOL PENTAFLUOROPHENYL ACRYLATE PENTAFLUOROPHENOXYACETIC ACID Pentafluorophenol 2,3,4-TRIFLUOROPHENOL FMOC-ASP(OTBU)-OPFP 2,3,5,6-TETRAFLUOROANISOLE PENTAFLUOROPHENYL METHACRYLATE 2,3,4-Trifluoroanisole 2,5-DINITROPHENOL

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  • 6418-38-8
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  • Phenols
  • Oxygen Compounds
  • Organic Building Blocks
  • Building Blocks
  • Phenyls & Phenyl-Het
  • Indolines ,Indoles ,Indazoles
  • Organic Building Blocks
  • Oxygen Compounds
  • Phenols
  • Fluorine series
  • Phenyls & Phenyl-Het
  • Phenol&Thiophenol&Mercaptan
  • Miscellaneous
  • Fluorophenols
  • Aromatic Halides (substituted)
  • Fluorobenzene
  • Alcohols and Derivatives
  • Trifluoromethoxybenzene Series
  • Other fluorin-contained compounds
  • bc0001