CORTISOL-9,11,12,12-D4
- Product Name
- CORTISOL-9,11,12,12-D4
- CAS No.
- 73565-87-4
- Chemical Name
- CORTISOL-9,11,12,12-D4
- Synonyms
- Hycort-d4;Acticort-d4;Hycortol-d4;Texacort-d4;TiMocort-d4;Cortisol-d4;D4-Cortisol;DerMacort-d4;Hydrocortal-d4;[2H4]-Cortisol
- CBNumber
- CB4234270
- Molecular Formula
- C21H26D4O5
- Formula Weight
- 366.49
- MOL File
- 73565-87-4.mol
CORTISOL-9,11,12,12-D4 Property
- Melting point:
- 211-214 °C
- Flash point:
- 9℃
- storage temp.
- -20°C Freezer
- solubility
- DMSO (Slightly), Ethanol (Slightly, Heated), Methanol (Slightly, Heated), Water
- form
- Solid
- color
- White to Off-White
- Appearance
- white powder
- CAS Number Unlabeled
- 50-23-7
Safety
- Hazard Codes
- Xn,T,F
- Risk Statements
- 63-39/23/24/25-23/24/25-11
- Safety Statements
- 36/37-45-16-7
- RIDADR
- UN1230 - class 3 - PG 2 - Methanol, solution
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H361Suspected of damaging fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C-113
- Product name
- Cortisol-D4 (9,11,12, 12-D4) solution
- Purity
- 100?μg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
- Packaging
- 1mL
- Price
- $483
- Updated
- 2025/07/31
- Product number
- 705594
- Product name
- Hydrocortisone-9,11,12,12-d4
- Purity
- 98 atom % D, 98% (CP)
- Packaging
- 5mg
- Price
- $913.9
- Updated
- 2025/07/31
- Product number
- 705594
- Product name
- Hydrocortisone-9,11,12,12-d4
- Purity
- 98 atom % D, 98% (CP)
- Packaging
- 10mg
- Price
- $1596
- Updated
- 2025/07/31
- Product number
- 26500
- Product name
- Hydrocortisone-d4
- Packaging
- 500μg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 26500
- Product name
- Hydrocortisone-d4
- Packaging
- 5mg
- Price
- $684
- Updated
- 2024/03/01
CORTISOL-9,11,12,12-D4 Chemical Properties,Usage,Production
Description
Hydrocortisone-d4 is intended for use as an internal standard for the quantification of hydrocortisone/cortisol by GC- or LC-MS. Cortisol, known as hydrocortisone when used as a therapeutic, is a glucocorticoid produced by the adrenal cortex in response to adrenocorticotropic hormone (ACTH). It is an agonist at the mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR), with an approximately 6- to 10-fold greater affinity for MR. Cortisol production is increased during periods of stress, and it is a major effector molecule in the hypothalamic-pituitary-adrenal axis (HPA) stress response. Cortisol levels increase with age and are often elevated in major depressive disorder, certain forms of hypertension, and Parkinson''s disease.
Chemical Properties
White Solid
Uses
Labelled Cortisol (H714615). Cortisol, or Hydrocortisone, is a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland. Cortisol is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis; suppress the immune system; and aid in fat, protein and carbohydrate metabolism.
Uses
Anti-inflammatory hormone
General Description
Cortisol, also known as hydrocortisone, is a glucocorticoid produced by the adrenal gland. This stable labeled internal standard is suitable for quantitation of cortisol levels in whole blood by LC-MS/MS for newborn screening of congenital adrenal hyperplasia (CAH) and in serum or plasma by LC-MS/MS for determination of several diseases including Cushing′s syndrome, Addison′s disease, and Sheehan′s syndrome.
References
[1] KRIEGER D T. Rhythms of acth and corticosteroid secretion in health and disease, and their experimental modification[J]. Journal of steroid biochemistry, 1975, 6 5: Pages 785-791. DOI: 10.1016/0022-4731(75)90068-0
[2] BOADIE W. DUNLOP Andrea W. The hypothalamic-pituitary-adrenal axis in PTSD: Pathophysiology and treatment interventions[J]. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 2019, 89: Pages 361-379. DOI: 10.1016/j.pnpbp.2018.10.010
[3] PAUL M. STEWART Christopher R W E. The cortisol-cortisone shuttle and hypertension[J]. Journal of Steroid Biochemistry and Molecular Biology, 1991, 40 4: Pages 501-509. DOI: 10.1016/0960-0760(91)90269-b
[4] FEMINA P. VARGHESE E S B. The Hypothalamic-Pituitary-Adrenal Axis in Major Depressive Disorder: A Brief Primer for Primary Care Physicians.[J]. Primary care companion to the Journal of clinical psychiatry, 2001, 3 4: 151-155. DOI: 10.4088/pcc.v03n0401
[5] NAYRON MEDEIROS SOARES. Cortisol levels, motor, cognitive and behavioral symptoms in Parkinson’s disease: a systematic review.[J]. Journal of Neural Transmission, 2019, 126 3: 219-232. DOI: 10.1007/s00702-018-1947-4
CORTISOL-9,11,12,12-D4 Preparation Products And Raw materials
Raw materials
Preparation Products
CORTISOL-9,11,12,12-D4 Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- +91-22-26355700
- Fax
- +91-22-26355701
- info@clearsynth.com
- Country
- India
- ProdList
- 9679
- Advantage
- 58
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
- 51395
- Advantage
- 80
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 13612807752
- ncchemical@163.com
- Country
- China
- ProdList
- 290
- Advantage
- 55
- Tel
- 025-84622273 17361806303
- kexin.zhou@haolvbiotech.com
- Country
- China
- ProdList
- 3019
- Advantage
- 58
- Tel
- +86-400-002-6226 +86-13028896684;
- sales@rrkchem.com
- Country
- China
- ProdList
- 57422
- Advantage
- 58
- Tel
- 18871490254
- Fax
- 027-59599243
- linda@hubeijusheng.com
- Country
- CHINA
- ProdList
- 28172
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11218
- Advantage
- 58