Meglumine

Product Name: Meglumine
CAS No.: 6284-40-8
Chemical Name: Meglumine
Synonyms: N-METHYL-D-GLUCAMINE;N-METHYLGLUCAMINE;Meglumin;Methylglucamine;1-deoxy-1-(methylamino)-d-glucito;MeguMine;Meglumine CRS;Methylglucamin;D(-)-N-METHYLGLUCAMINE;1-DEOXY-1-(METHYLAMINO)-D-GLUCITOL
CBNumber: CB6411710
Molecular Formula: C7H17NO5
Formula Weight: 195.21
MOL File: 6284-40-8.mol

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Meglumine Property

Melting point:: 129-131.5 °C (lit.)
alpha: -16.5 º (c=10, H2O, on dry sub)
Boiling point:: 331.88°C (rough estimate)
Density: 1.2669 (rough estimate)
refractive index: -16.5 ° (C=2, H2O)
RTECS: LZ4295770
storage temp.: 2-8°C
solubility: H₂O: 0.1 g/mL, clear, colorless
form: Crystalline Powder
pka: pKa 9.39(H2O,t =30.0,I=0.05N2)(Approximate)
color: White to almost white
PH: 11 (10g/l, H2O, 20℃)
optical activity: [α]20/D 16.5±0.5°, c = 2% in H2O
Water Solubility: 100 g/100 mL (25 ºC)
Sensitive: Air Sensitive & Hygroscopic
Merck: 14,6078
BRN: 385906
InChIKey: MBBZMMPHUWSWHV-VZFHVOOUSA-N
LogP: -3.370 (est)
NIST Chemistry Reference: N-methylglucamine(6284-40-8)
EPA Substance Registry System: Meglumine (6284-40-8)

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Safety

Risk Statements: 36/37/38
Safety Statements: 24/25
WGK Germany: 3
F: 3-10-23
Autoignition Temperature: ~662 °F
TSCA: Yes
HS Code: 29221980
Toxicity: LD50 orally in Rabbit: > 5000 mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 66930
Product name: N-Methyl-D-glucamine
Purity: ReagentPlus , ≥99.0% (T)
Packaging: 100g
Price: $67.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.18318
Product name: D(-)-N-Methylglucamine
Purity: for resolution of racemates for synthesis
Packaging: 250g
Price: $72.3
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1379140
Product name: Meglumine
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 500mg
Price: $436
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1.06143
Product name: Meglumine
Purity: low in endotoxins, EMPROVE? API, Ph. Eur., ChP, JP, USP
Packaging: 1KG
Price: $244
Updated: 2022/05/15

Sigma-Aldrich

Product number: 1.06187
Product name: Meglumine
Purity: EMPROVE? ESSENTIAL, Ph. Eur., ChP, JP, USP
Packaging: 1KG
Price: $244
Updated: 2022/05/15

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Meglumine Chemical Properties,Usage,Production

Chemical Properties

white to almost white crystalline powder

Chemical Properties

Meglumine occurs as a white to slightly yellow-colored crystalline powder; it is odorless or with a slight odor.

Uses

antiinflammatory

Uses

excipient in cosmetics and X-ray contrast media

Uses

N-Methyl-D-glucamine is used in conjunction with iodinated organic compounds in contrast media viz. diatrizoate meglumine and iodipamide meglumine. It is useful in ion-exchange resins to chelate boron ions selectively. It is also used as an excipient in pharmaceuticals, in cosmetics and X-ray contrast media. It is also employed in the synthesis of surface active agents, pharmaceuticals and dyes.

Production Methods

Meglumine is prepared by the imination of glucose and monomethylamine, in an alcoholic solution, followed by catalytic hydrogenation.

Definition

ChEBI: A hexosamine that is D-glucitol in which the hydroxy group at position 1 is substituted by the nitrogen of a methylamino group. A crystalline base, it is used in preparing salts of certain acids for use as diagnostic radiopaque media, whi e its antimonate is used as an antiprotozoal in the treatment of leishmaniasis.

brand name

Renovue (Bracco).

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Meglumine is a glucose-derived secondary amine which is widely used as an excipient in pharmaceutical formulations.

Pharmaceutical Applications

Meglumine is an organic base used as a pH-adjusting agent and solubilizing agent, primarily in the preparation of soluble salts of iodinated organic acids used as X-ray contrast media.

Safety

Meglumine is widely used in parenteral pharmaceutical formulations and is generally regarded as a nontoxic material at the levels usually employed as an excipient.
LD₅₀ (mouse, IP): 1.68 g/kg

storage

Meglumine does not polymerize or dehydrate unless heated above 150°C for prolonged periods.
The bulk material should be stored in a well-closed container in a cool, dry place. Meglumine should not be stored in aluminum containers since it reacts to evolve hydrogen gas; it discolors if stored in containers made from copper or copper alloys. Stainless steel containers are recommended.

Purification Methods

Crystallise N-methyl-D(-)-glucamine from MeOH. Its solubility in H2O is 10%. [Karrer & Herkenrath Helv Chim Acta 20 83 1957 also for other N-alkyl derivatives, Beilstein 4 IV 1914.]

Incompatibilities

Incompatible with aluminum, copper, mineral acids, and oxidizing materials. Differential scanning calorimetry studies suggest meglumine is incompatible with glipizide.

Regulatory Status

Included in the FDA Inactive Ingredients Database (injections; oral tablets). Included in parenteral medicines licensed in the UK.

Meglumine Preparation Products And Raw materials

Raw materials

weak 1-Glucose-methylamine schiffbase ACETALDEHYDE AMMONIA

Preparation Products

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Meglumine Suppliers

Americas 1 Belgium 3 Brazil 1 Canada 1 China 558 Czech Republic 1 Europe 4 Germany 11 India 39 Japan 6 Mexico 1 Poland 1 Russia 1 South Korea 2 Spain 1 Switzerland 4 The Netherlands 1 United Kingdom 21 United States 64 Global 721

BTC pharm India

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Vanamali Organics Pvt., Ltd.

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CHEMSWORTH

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View Lastest Price from Meglumine manufacturers

HebeiShuoshengImportandExportco.,Ltd

Product: Meglumine 6284-40-8
Price: US $6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000KG/Month
Release date: 2024-08-06

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Meglumine 6284-40-8
Price: US $75.00-20.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-05-30

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Meglumine 6284-40-8
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 99%min
Supply Ability: 500kgs
Release date: 2021-09-29

6284-40-8, MeglumineRelated Search:

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1-deoxy-1-(methylamino)-d-glucito

1-Deoxy-1-(methylamino)hexitol

Glucitol, 1-deoxy-1-(methylamino)-, D-

Meglumin

Methylglucamin

Methylglucamine

D-GLUCITOL, 1-DEOXY-1-(METHYLAMINO)-

D(-)-N-METHYLGLUCAMINE

MEGLUMINE

1-DEOXY-1-(METHYLAMINO)GLUCITOL

1-DEOXY-1-METHYLAMINOSORBITOL

1-DEOXY-1-(METHYLAMINO)-D-GLUCITOL

N-METHYL-D(-)-GLUCAMINE

N-METHYL-D-GLUCAMINE

N-METHYLGLUCAMINE

Methylglucamine,99%

<i>N</i>-Methyl-<i>D</i>-glucamine

N-Methyl-D-Glucamine(Or) Meglumine

N-Methyl-D-glucamine Vetec(TM) reagent grade, 99%

Fosaprepitant Impurity H

C7H18NO5

D(-)-N-Methylglucamine for resolution of racemates for synthesis

methyl-[(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]ammonium

ucamine

N-Methyl-D-Glu

METHYL GLUCAMINE MEGLUMINE

MEGLUMINE, USP

N-Methylglucamine (Meglumine)

N-Methyl-D-Glucamine>99%

MeglumineAntimoniateBase

N-METHYL-D-GLUCANINE

MEGLUMINE(N-METHYLGLUCAMINE)

N-METHYLCYCLOHEXALAMINE

N-METHYL-D-GLUCAMINE USP

1-(Methylamino)-1-deoxy-D-glucitol

1-Methylamino-1-deoxy-D-glucitol

D-1-Deoxy-1-(methylamino)glucitol

MegluMine (AS)

Meglumine, 1-Deoxy-1-(methylamino)-D-glucitol, (2R,3R,4R,5S)-6-Methylaminohexane-1,2,3,4,5-pentaol, 1-Deoxy-1-methylaminosorbitol

N-MethylglucaMin (MegluMine)

Meglumine (500 mg) (AS)

N-Methyl-D-glucaMine, 99% 100GR

N-Methyl-D-glucaMine, 99% 2.5KG

N-Methyl-D-glucaMine, 99% 500GR

MegluMine,USP,BP,EP

MeguMine

N-Methyl-D-glucaMine 99.0-100.5% (titration)

N-Methyl-D-glucaMine ReagentPlus(R), >=99.0% (T)

N-Methyl-D-glucaMine , 99.0%(T)

N-MethylglucaMine USP

D(-)-N-METHYLGLUCAMINE FOR RESOLUTION OF

(2R,3R,4R,5S)-6-(MethylaMino)hexane-1,2,3,4,5-pentaol

The most popular N-methylglucamine

Meglumine CRS

N-Methyl-D-glucamine, 99%, reagent grade

N-Methyl-D-glucamine&gt

-D-gL

Meglumine, USP, EP, BP