Pranoprofen

Product Name: Pranoprofen
CAS No.: 52549-17-4
Chemical Name: Pranoprofen
Synonyms: 2-(5H-Chromeno[2,3-b]pyridin-7-yl)propanoic acid;Niflan;Y 8004;Cesflan;Oftalar;ranoprofen;PRANOPROFEN;pyranoprofen;dl-Pranoprofen;(RS)-Pranoprofen
CBNumber: CB9189564
Molecular Formula: C15H13NO3
Formula Weight: 255.27
MOL File: 52549-17-4.mol

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Pranoprofen Property

Melting point:: 182-183°
Boiling point:: 398.5°C (rough estimate)
Density: 1.1654 (rough estimate)
refractive index: 1.5500 (estimate)
storage temp.: 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 4.27±0.10(Predicted)
form: powder
color: white to beige
CAS DataBase Reference: 52549-17-4(CAS DataBase Reference)

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Safety

RIDADR: UN 2811 6.1 / PGIII
RTECS: DJ3100950
Toxicity: LD50 in male mice, rats (mg/kg): 447.3, 87.3 orally (Edanaga)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1423
Product name: Pranoprofen
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $38.9
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1423
Product name: Pranoprofen
Purity: ≥98% (HPLC)
Packaging: 250mg
Price: $115
Updated: 2024/03/01

Cayman Chemical

Product number: 17875
Product name: Pranoprofen
Purity: ≥98%
Packaging: 50mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 17875
Product name: Pranoprofen
Purity: ≥98%
Packaging: 1g
Price: $359
Updated: 2024/03/01

Cayman Chemical

Product number: 17875
Product name: Pranoprofen
Purity: ≥98%
Packaging: 100mg
Price: $61
Updated: 2024/03/01

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Pranoprofen Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Originator

Niflan, Yoshitomi ,Japan ,1981

Uses

Pranoprofen is an anti-inflammatory used in ophthalmology.

Definition

ChEBI: Pranoprofen is a pyridochromene.

Manufacturing Process

A mixture of 100 g of ethyl 2-cyano-2-(5H-[1]benzopyrano[2,3-b]-pyridin-7yl)propionate, 500 ml of glacial acetic acid and 200 g of concentrated hydrochloric acid is refluxed for 48 hours. The reaction mixture is concentrated, and the residue is dissolved in hot water. The solution is adjusted to pH 2 to 3 by addition of 10% sodium hydroxide. The resulting crystalline precipitate is washed thoroughly with water, and recrystallized from aqueous dioxane to give 74 g of 2-(5H-[1]benzopyrano[2,3-b]-pyridin-7yl)propionic acid as white crystals melting at 183°C to 183.5°C.

Therapeutic Function

Analgesic, Antiinflammatory

General Description

Pranoprofen is an arylalkanoic acid and a non-steroidal anti-inflammatory drug.

Biochem/physiol Actions

Pranoprofen is used in eyes to treat chronic allergic conjunctivitis. It is also used as an anti-inflammatory and analgesic drug after strabismus surgery.

Pranoprofen Preparation Products And Raw materials

Raw materials

Preparation Products

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Pranoprofen Suppliers

Canada 1 China 251 Europe 3 Germany 1 India 2 Japan 1 United Kingdom 5 United States 25 Global 289

TOKYO CHEMICAL INDUSTRY CO., LTD.

Tel: 03-36680489
Fax: 03-3668-0520
Email: Sales-JP@TCIchemicals.com
Country: Japan
ProdList: 28398
Advantage: 80

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View Lastest Price from Pranoprofen manufacturers

Ouhuang Engineering Materials (Hubei) Co., Ltd

Product: Pranoprofen 52549-17-4
Price: US $15.00/kg
Min. Order: 1kg
Purity: 99.912%
Supply Ability: 10ton
Release date: 2024-04-25

Guangzhou PI PI BIOTECH INC

Product: Pranoprofen 52549-17-4
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 90%+
Supply Ability: 10g
Release date: 2021-09-17

airuikechemical co., ltd.

Product: Pranoprofen 52549-17-4
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 20 tons
Release date: 2024-04-07

52549-17-4, PranoprofenRelated Search:

Centchroman Imidocarb dipropionate Folic acid Propionic acid Nandrolone phenylpropionate 3-(4-Hydroxyphenyl)propionic acid Ethyl 2-(Chlorosulfonyl)acetate 3-Phenylpropionic acid Ascoric Acid Ibuprofen N,N-dimethylcarbamoylmethyl alpha,2-dimethyl-5H-1-benzopyrano(2,3-b)pyridine-7-acetate ALFA-METHYL-5H-[1] BENZOPYRANO [2,3-B] PYRIDINE-7-ACETIC ACID ETHYL ESTER 4-METHOXY-3-METHYLPHENYLACETIC ACID Pranoprofen l-Pranoprofen,(S)-(+)-Pranoprofen (R)-Pranoprofen,(R)-(-)-Pranoprofen,d-Pranoprofen 2-(4-METHOXY-3-METHYLPHENYL)ACETALDEHYDE ALFA-METHYL-ALFA-CYANO-5H-[1] BENZOPYRANO [2,3-B] PYRIDINE-7-ACETIC ACID ETHYL ESTER

PRANOPROFEN

(RS)-Pranoprofen

5H-[1]Benzopyrano[2,3-b]pyridine-7-acetic acid, a-methyl- (9CI)

a-Methyl-5H-[1]benzopyrano[2,3-b]pyridine-7-ylacetic acid

dl-Pranoprofen

Niflan

Y 8004

pyranoprofen

(S)-2-[5H-[1]Benzopyrano[2,3-b]pyridin-7-yl]propionic acid

[S,(+)]-2-[5H-[1]Benzopyrano[2,3-b]pyridin-7-yl]propionic acid

(R)-2-[5H-[1]Benzopyrano[2,3-b]pyridin-7-yl]propionic acid

[R,(-)]-2-[5H-[1]Benzopyrano[2,3-b]pyridin-7-yl]propionic acid

Cesflan

α-Methyl-5H-[1]benzopyrano[2,3-b]pyridine-7-acetic acid

2-(5h-[1]benzopyrano[2,3-b]pyridin-7-yl)propionic acid

Oftalar

Pranoprofen, >=99%

5H-[1]Benzopyrano[2,3-b]pyridine-7-aceticacid, a-methyl-

Pranoprofen-13C-d3

Pranoprofen（mixture of isomers）

5H-[1]Benzopyrano[2,3-b]pyridine-7-acetic acid, α-methyl-

(2S)-2-(5H-chromeno[2,3-b]pyridin-7-yl)propanoic acid

2-(5H-Chromeno[2,3-b]pyridin-7-yl)propanoic acid

Pranoprofen USP/EP/BP

Pranoprofen (Pyranoprofen)

Antipyretic analgesics Pranoprofen

ranoprofen

52549-17-4

NIFLAN

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

>97%,BR

52549-17-4