N2,9-Diacetylguanine
- Product Name
- N2,9-Diacetylguanine
- CAS No.
- 3056-33-5
- Chemical Name
- N2,9-Diacetylguanine
- Synonyms
- DIACETYL GUANINE;2,9-DIACETYLGUANINE;N2,9-DIACETYLGUANINE;2,9-DAG;9-diacetylguanine;N,9-DIACETYLGUANINE;2,9-DIACETATEGUANINE;2,9-Guanine Diacetate;N2,N9-Diacetylguanine;Acyclovir EP Impurity L
- CBNumber
- CB6183086
- Molecular Formula
- C9H9N5O3
- Formula Weight
- 235.2
- MOL File
- 3056-33-5.mol
N2,9-Diacetylguanine Property
- Melting point:
- 285 °C(lit.)
- Density
- 1.67±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Aqueous Base (Slightly, Heated), DMSO (Slightly, Heated)
- form
- Solid
- pka
- 8.37±0.20(Predicted)
- color
- White to Light Beige
- InChI
- InChI=1S/C9H9N5O3/c1-4(15)11-9-12-7-6(8(17)13-9)10-3-14(7)5(2)16/h3H,1-2H3,(H2,11,12,13,15,17)
- InChIKey
- GILZZWCROUGLIS-UHFFFAOYSA-N
- SMILES
- C(NC1NC(=O)C2=C(N=1)N(C(C)=O)C=N2)(=O)C
- CAS DataBase Reference
- 3056-33-5(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-37/39-36
- WGK Germany
- 3
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- D3604
- Product name
- N2,9-Diacetylguanine
- Purity
- >95.0%(T)
- Packaging
- 25g
- Price
- $92
- Updated
- 2024/03/01
- Product number
- B22709
- Product name
- N(2),9-Diacetylguanine, 99%
- Packaging
- 5g
- Price
- $51.65
- Updated
- 2024/03/01
- Product number
- D335000
- Product name
- N2,9-Diacetylguanine
- Packaging
- 50g
- Price
- $200
- Updated
- 2021/12/16
- Product number
- D3441-50
- Product name
- N 2,9-Diacetylguanine
- Packaging
- 10g
- Price
- $319
- Updated
- 2021/12/16
- Product number
- D335000
- Product name
- N2,9-Diacetylguanine
- Packaging
- 100g
- Price
- $400
- Updated
- 2021/12/16
N2,9-Diacetylguanine Chemical Properties,Usage,Production
Description
N2,9-Diacetylguanine is a purine compound that can be prepared by acetylation of guanine with acetic anhydride. It can be used in many fields such as organic synthesis, biological research and pharmaceutical manufacturing. N2,9-Diacetylguanine can be prepared into 2-amino-6-halogenated purine under the action of two-step PEG-2000 phase transfer catalyst and TPPB phase transfer catalyst, and further through the corresponding CuX-catalyzed diazotization reaction, new 2-halogenated purine compounds can be efficiently synthesized[2]. In addition, it can also be used as an intermediate for the antiviral drugs Ganciclovir and Aciclovir.
Chemical Properties
white or brownish crystalline powder
Uses
N2,9-Diacetylguanine (Acicclovir EP Impurity L) is used to synthesize acyclic analogues of deoxyguanosine.
Application
The alkylation of N2,N9- diacetylguanine (DAG) with 2-oxa-1, 4-butane-dioldiacetate to give N2-acetyl-9-{2-acetoxyethoxymethyl}- guanine (N9 isomer) and/or N2-acetyl-7-{2-acetoxyethoxymethyl}- guanine (N7 isomer) in exceptionally high regioselectivity[1].
References
[1] Dharmendra Singh, Ashok Kumar, Mukesh J. Wani. “A Simple Solution to the Age Old Problem of Regioselective Functionalization of Guanine: First Practical Synthesis of Acyclic N9- and/or N7-Guanine Nucleosides Starting from N2,N9-Diacetylguanine.” The Journal of Organic Chemistry 64 13 (1999): 4665–4668.
[2] Y. HU. Synthesis of Some Biologically Active Halogenopurines[J]. Journal of the Korean Chemical Society-Daehan Hwahak Hoe Jee, 2010. DOI:10.5012/JKCS.2010.54.4.429.
N2,9-Diacetylguanine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N2,9-Diacetylguanine manufacturers
- Product
- N,9-Diacetylguanine 3056-33-5
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 500kgs/month
- Release date
- 2021-10-28
- Product
- N(2),9-Diacetylguanine 3056-33-5
- Price
- US $0.00/Kg
- Min. Order
- 1Kg
- Purity
- 98%
- Supply Ability
- 20Ton
- Release date
- 2024-10-29
- Product
- N,9-Diacetylguanine 3056-33-5
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2021-09-06