Guanosine

Description Reference

Product Name: Guanosine
CAS No.: 118-00-3
Chemical Name: Guanosine
Synonyms: GR;2-amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,9-dihydro-6H-purin-6-one;VERNINE;2-AMINO-9-BETA-D-RIBOFURANOSYL-9H-PURINE-6-(1H)-ONE;2-amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one;Guo;GCCR;Guanyin;Guanozin;uanosine
CBNumber: CB2701721
Molecular Formula: C10H13N5O5
Formula Weight: 283.24
MOL File: 118-00-3.mol

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Guanosine Property

Melting point:: 250 °C (dec.) (lit.)
alpha: -62 º (c=3, in 0.1 N NaOH)
Boiling point:: 425.8°C (rough estimate)
Density: 1.3790 (rough estimate)
refractive index: -76 ° (C=1, 1mol/L NaOH)
storage temp.: room temp
solubility: 0.1 M NaOH: 0.1 g/mL, clear, slightly yellow
pka: pK1:1.9(＋1);pK2:9.25(0);pK3:12.33(OH) (25°C)
form: Powder
color: White to light yellow
Odor: Odorless
PH: 2.14；9.03
optical activity: [α]20/D -73±2°, c = 1.5% in 1 M NaOH
Water Solubility: 0.75 g/L (25 ºC)
λmax: 256 (pH 0.7)；253，276 (pH 7)；256～266 (pH 11.3)
Merck: 14,4566
BRN: 625911
InChIKey: NYHBQMYGNKIUIF-UUOKFMHZSA-N
LogP: -2.331 (est)
CAS DataBase Reference: 118-00-3(CAS DataBase Reference)
NIST Chemistry Reference: guanosine(118-00-3)
EPA Substance Registry System: Guanosine (118-00-3)

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Safety

Hazard Codes: T,Xi
Risk Statements: 25
Safety Statements: 45-24/25-23
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: MF8750000
F: 10-23
Hazard Note: Irritant
TSCA: Yes
HazardClass: 6.1
PackingGroup: Ⅲ
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 75903
Product name: Guanosine
Purity: ≥97.0% (HPLC)
Packaging: 100g
Price: $294
Updated: 2024/03/01

Sigma-Aldrich

Product number: 75903
Product name: Guanosine
Purity: ≥97.0% (HPLC)
Packaging: 500g
Price: $1140
Updated: 2023/06/20

TCI Chemical

Product number: G0171
Product name: Guanosine
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $19
Updated: 2024/03/01

TCI Chemical

Product number: G0171
Product name: Guanosine
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $36
Updated: 2024/03/01

Alfa Aesar

Product number: A11328
Product name: Guanosine, 98+%
Packaging: 25g
Price: $56.4
Updated: 2024/03/01

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Guanosine Chemical Properties,Usage,Production

Description

Guanosine is a purine nucleoside, in which the guanine attached to the C1 carbon of a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Its phosphorylated derivatives include GMP (guanosine monophosphate), cGMP (cyclic guanosine monophosphate), GDP (guanosine diphosphate), and GTP (guanosine triphosphate). These guanosine derivatives are very important in various biochemical processes, such as synthesis of nucleic acids and proteins, photosynthesis, muscle contraction, and intracellular signal transduction.
Guanosine is thought to have neuroprotective properties. It can reduce neuroinflammation, oxidative stress, and excitotoxicity, as well as exerting trophic effects in neuronal and glial cells. It is shown to be protective in central nervous system diseases including ischemic stroke, Alzheimer’s disease, Parkinson’s disease, spinal cord injury, nociception, and depression. Guanosine is found to be associated with purine nucleoside phosphorylase (PNP) deficiency, which is an inborn error of metabolism.

Reference

L. E. B. Bettio, J. Gil-Mohapel, A. L. S. Rodrigues, Guanosine and its role in neurophathologies, Purinergic Signal, 2016, vol. 12, pp. 411-426

Description

Guanosine is a purine nucleoside that is comprised of the purine base guanine attached to a ribose moiety. Mono-, di-, tri-, and cyclic monophosphorylated forms of guanosine (GMP, GDP, GTP, and cGMP, respectively) are essential for a variety of endogenous biochemical processes, such as signal transduction, metabolism, and RNA synthesis.

Chemical Properties

White, crystalline powder; odorless; mild saline taste. Very slightly soluble in cold water; soluble in boiling water, dilute mineral acids, hot acetic acid, and dilute bases; insoluble in alcohol, ether, chloroform, and benzene.

Uses

Guanosine is used as a constituent of nucleic acids. It is used in metallic paints, simulated pearls,plastics,cosmetics industry etc,. It has been also used in pharmacokinetics as a prodrug. Guanosine is used in cell culture applications as a precursor of GMP.

Uses

Guanosine has been used:

as a reference standard for the analysis of glucosinolates by high-performance liquid chromatography with diode-array detection and electrospray ionization tandem mass spectrometry (HPLC-DAD-ESI/MS)
as a component of Mouse Embryonic Fibroblasts (MEFs) culture
as a standard for the detection of residual RNA contaminant in oil palm plant genome samples by HPLC

Definition

A NUCLEOSIDE present in DNA and RNA and consisting of guanine linked to D-ribose via a β-glycosidic bond.

Definition

ChEBI: A purine nucleoside in which guanine is attached to ribofuranose via a beta-N9-glycosidic bond.

General Description

Guanosine is an aromatic organic molecule and a purine nucleoside. It is present in the cerebrospinal fluid, intestinal cells, blood-brain barrier and in brain microvessels.

Biochem/physiol Actions

Guanosine nucleoside elicits cellular effect as the guanine-based purinergic system. It modulates glutamate uptake by glutamate transporters. It may have neuroprotective functionality in central nervous system disorders. Guanosine promotes neurite arborization, outgrowth, proliferation and differentiation. Administration of guanosine replenished GTP and elicits protective function in renal ischemic injury.

Purification Methods

It crystallises from water as a dihydrate. Dry it at 110o.[Beilstein 26/18 V 81.]

Guanosine Preparation Products And Raw materials

Raw materials

Preparation Products

Ribavirin N2,9-Diacetylguanine Calcium 5'-ribonucleotide Guanosine 5'-monophosphate disodium salt 5'-Guanylic acid 7-METHYLGUANINE Acyclovir

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Guanosine Suppliers

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View Lastest Price from Guanosine manufacturers

Xinxiang Aurora Biotechnology Co.,Ltd.

Product: Guanosine 118-00-3
Price: US $10.00/Kg
Min. Order: 1Kg
Purity: 98%
Supply Ability: 20Ton
Release date: 2024-10-31

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Guanosine 118-00-3
Price: US $79.00-38.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-11-19

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Guanosine 118-00-3
Price: US $0.00-0.00/Kg/Drum
Min. Order: 25KG
Purity: 98%min
Supply Ability: 10 TONS
Release date: 2021-06-16

118-00-3, GuanosineRelated Search:

GUANOSINE-3':5'-CYCLIC MONOPHOSPHORIC ACID GUANOSINE 5'-DIPHOSPHATE SODIUM SALT Uridine UDP Uridine-5'-diphosphate disodium salt guanosine 5'-(tetrasodium triphosphate) Guanosine 5'-triphosphate trisodium salt URIDINE 5'-DIPHOSPHORIC ACID SODIUM SALT URIDINE-13C9, 15N2-5 TRIPHOSPHATE SODI U Uridine-5'-triphosphoric acid trisodium salt 2',3',5'-Triacetylguanosine N2-METHYLGUANOSINE 5'-Guanylic acid GUANOSINE-3',5'-CYCLIC-MONOPHOSPHORIC ACID SODIUM SALT,GUANOSINE 3',5'-MONOPHOSPHATE MONOSODIUM SALT,GUANOSINE 3',5'-CYCLOPHOSPHATE MONOSODIUM SALT GUANOSINE 5'-DIPHOSPHATE 2-Amino-6-chloropurine-9-riboside Purine Guanine

usafcb-11

O-(BETA-D-RIBOFURANOSYL)GUANINE

D-GUANOSINE

GR

GUANOSINE

GUANINE-9-BETA-D-RIBOFURANOSIDE

GUANINE RIBOSIDE

9-[BETA-D-RIBOFURANOSYL]GUANINE

9-B-D-RIBOFURANOSYLGUANINE

2-AMINO-9-BETA-D-RIBOFURANOSYL-9H-PURINE-6-(1H)-ONE

9-(β-D-Ribofuranosyl)guanine

Guanine-9-β-D-ribofuranoside

guanosine cell culture tested

Guanosine Guanine 9-B-D-ribofuranoside

guanosine minimum 99%

GUANOSINE CELL CULTURE REAGENT 97-103% USP

GUANOSINE ULTRA PURE 98+%

Guanine-9-β-D-ribof

GuanosineForBiochemistry

Guanosine, 98+%

2-AMINO-9-BETA-D-RIBOFURANOSYL-9H-PURINE-6-(1H)-ONE (GUANOSINE)

2-Amino-9-β-D-ribofuranosyl-[9H]-purine-6-[1H]-one

GUANOSINE,REAGENT

2-Amino-9-beta-D-ribofuranosyl-9H-purine-6-(1H)-one hydrate

Guanine-9-beta-ribofuranoside

2-amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one

GUANOSINE extrapure

9-(β-D-Ribofuranosyl)guanine, Guanine-9-β-D-ribofuranoside

2-Amino-9-(β-D-ribofuranosyl)-9H-purin-6(1H)-one

Guanosine,99%

2-aMino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxyMethyl)oxolan-2-yl]-6,9-dihydro-1H-purin-6-one

2-AMino-1,9-dihydro-9-β-D-ribofuranosyl-6H-purin-6-one

2-aMino-9-β-d-ribofuranosyl-9h-purine-6-(1h)-one hydrate

[1',2',3',4',5'-13C5]guanosine Mono-hydrate

[2'-2H]guanosine Monohydrate

[3'-2H]guanosine Monohydrate

Adenosine EP Impurity H

GCCR

Guanosine Vetec(TM) reagent grade, >=98%

2-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxy-methyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-

Guanosine, Low endotoxin: ≤ 0.5 EU/mgGrade 1, ≥ 99% (HPLC)

2-amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,9-dihydro-6H-purin-6-one

Guanine riboside Guanine riboside

VERNINE

2(3H)-Imino-9-beta-D-ribofuranosyl-9H-purin-6(1H)-one

2-Amino-1,9-dihydro-9beta-d-ribofuranosyl-6H-purin-6-one

2-amino-inosin

6H-Purin-6-one, 2-amino-1,9-dihydro-9-beta-d-ribofuranosyl-

9-beta-d-ribofuranosyl-guanin

beta-d-Ribofuranoside, guanine-9

Guanine, 9beta-d-ribofuranosyl-

guanine-9,beta-d-ribofuranosid

Guanozin

Guo

Inosine, 2-amino-

Ribofuranoside, guanine-9, beta-D-

USAF cb-11

uanosine